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Peer-reviewedCC BYHepatology International

APASL clinical practice guidelines on the management of chronic hepatitis B infection: a 2026 update

  • Hong You1
  • Rakhi Maiwall2
  • Jing Chen3
  • Sang Hoon Ahn4
  • Kadir Dokmeci5
  • 窦晓光6
  • Manal El-Sayed7
  • Jian-Gao Fan8
  • Rino Gani9
  • Zhiliang Gao10
  • Jacob George11
  • Hasmik Ghazinian12
37 more authors
  • George Goh13
  • Saeed Hamid14
  • Jinlin Hou15
  • Shang‐Chin Huang16
  • Dong Ji17
  • Jidong Jia1
  • Tatsuo Kanda18
  • Jia‐Horng Kao19
  • Yoon Jun Kim20
  • Cosmas Rinaldi A. Lesmana21
  • Rosmawati Binti Mohamed22
  • Qin Ning23
  • Necati Ormeci24
  • Motoyuki Otsuka25
  • Diana Payawal26
  • Pham Thanh Thuy27
  • Keo Sailey28
  • Manoj Kumar Sharma2
  • Jose Decena Sollano29
  • Jian Sun15
  • Tawesak Tanwandee30
  • Alexander J. V. Thompson31
  • Fang Wang32
  • Guiqiang Wang33
  • Lai Wei34
  • Grace Lai‐Hung Wong35
  • Vincent Wai Sun Wong35
  • Eng Kiong Yeoh3
  • Terry Cheuk‐Fung Yip36
  • Ming‐Lung Yu37
  • Wenhong Zhang38
  • Hui Zhuang39
  • Ching‐Lung Lai40
  • Masao Omata
  • Shiv Kumar Sarin2
  • George K.K. Lau
  • APASL Viral Elimination Taskforce
40 affiliations
  1. 1Beijing Friendship Hospital, Capital Medical University, Beijing, China
  2. 2Institute of Liver and Biliary Sciences, New Delhi, India
  3. 3JC School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China
  4. 4Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, South Korea
  5. 5Liver Transplantation Center, Bahçeşehir University, Istanbul, Turkey
  6. 6Department of Infectious Diseases, Shengjing Hospital of China Medical University, Shenyang, China
  7. 7Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt
  8. 8Center for Fatty Liver, Department of Gastroenterology, Shanghai Key Lab of Pediatric Gastroenterology and Nutrition, Xin Hua Hospital, Shanghai Jiao Tong University, Shanghai, China
  9. 9Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
  10. 10Hepatic Hospital, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China
  11. 11Storr Liver Centre, The Westmead Millennium Institute for Medical Research, Westmead Hospital, The University of Sydney, Sydney, Australia
  12. 12Yerevan Medical Scientific Center, Yerevan, Armenia
  13. 13Department of Gastroenterology & Hepatology, Singapore General Hospital, Singapore, Singapore
  14. 14Aga Khan University, Karachi-74800, Pakistan
  15. 15Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China
  16. 16Hepatitis Research Center, National Taiwan University Hospital, Taipei, Taiwan
  17. 17Senior Department of Hepatology, Fifth Medical Center of Chinese, PLA General Hospital, Beijing, China
  18. 18Division of Gastroenterology and Hepatology, Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital, Minamiuonuma, 949-7302, Japan
  19. 19National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan
  20. 20Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, 03080, South Korea
  21. 21Department of Gastroenterology & Hepatology, Dr. Cipto Mangunkusumo National General Hospital, Medical Faculty Universitas Indonesia, Jakarta, Indonesia
  22. 22Department of Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia
  23. 23Department and Institute of Infectious Disease, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
  24. 24Istanbul Health and Technology University, Istanbul, Turkey
  25. 25Department of Gastroenterology and Hepatology, Okayama University, Okayama, Japan
  26. 26Department of Medicine, Cardinal Santos Medical Center, Mandaluyong, Philippines
  27. 27Partnership for Health Advancement in Vietnam, Hanoi, Vietnam
  28. 28Communicable Disease Control Department & Secretariat of Viral Hepatitis, Ministry of Health, Phnom Penh, Cambodia
  29. 29Faculty of Medicine and Surgery, University of Santo Tomas, Manila, Philippines
  30. 30Division of Gastroenterology, Faculty of Medicine Siriraj Hospital, Mahidol University, Salaya, Thailand
  31. 31St. Vincent's Hospital Melbourne, University of Melbourne, Melbourne, Australia
  32. 32Treatment and Research Center for Infectious Diseases, The Fifth Medical Center of PLA General Hospital, Beijing, 100039, China
  33. 33Department of Infectious Disease, Center for Liver Disease, Peking University First Hospital, Beijing, China
  34. 34School of Clinical Medicine, Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing, China
  35. 35Medical Data Analytics Centre, Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China
  36. 36Medical Data Analytics Centre, Department of Medicine & Therapeutics, Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China
  37. 37Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
  38. 38Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, Huashan Hospital, Fudan University, Shanghai, China
  39. 39Department of Microbiology and Centre for Infectious Diseases, Peking University Health Science Centre, Beijing, China
  40. 40The University of Hong Kong, Hong Kong SAR, China
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Abstract

Globally, especially in the Asia Pacific region, chronic hepatitis B infection has led to an undesirable escalating morbidity and mortality with acute-on chronic liver failure, end-staged liver cirrhosis, and hepatocellular carcinoma. This has happened despite the past four decades of major scientific advances made in screening methods, vaccination strategies, highly effective low-cost anti-viral therapies, and surveillance strategies for early detection of hepatocellular carcinoma. To address this health threat, APASL has formed a Viral Elimination Taskforce to unite key opinion leaders from its member countries and regions. The ongoing shifts in hepatitis B epidemiology, socioeconomic changes, and advancements in technology are taken into consideration. With the conjoint efforts of all the members of the APASL Viral Elimination Taskforce, these clinical practice guidelines have been formulated aiming to facilitate healthcare professionals, policy-makers, and patients in making practical and cost-effective management decisions for chronic hepatitis B infection. Altogether, it provides recommendations in 13 major areas related to screening, vaccination, treatment, and HCC surveillance. The implementation of these clinical practice guidelines represents major APASL effort toward elimination of the disease burden due to chronic hepatitis B infection in Asia Pacific region.

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Cite

BibTeXRIS
BibTeX
@article{you2026apasl,
  title = {{APASL clinical practice guidelines on the management of chronic hepatitis B infection: a 2026 update}},
  author = {Hong You and Rakhi Maiwall and Jing Chen and Sang Hoon Ahn and Kadir Dokmeci and 窦晓光 and Manal El-Sayed and Jian-Gao Fan and Rino Gani and Zhiliang Gao and Jacob George and Hasmik Ghazinian and George Goh and Saeed Hamid and Jinlin Hou and Shang‐Chin Huang and Dong Ji and Jidong Jia and Tatsuo Kanda and Jia‐Horng Kao and Yoon Jun Kim and Cosmas Rinaldi A. Lesmana and Rosmawati Binti Mohamed and Qin Ning and Necati Ormeci and Motoyuki Otsuka and Diana Payawal and Pham Thanh Thuy and Keo Sailey and Manoj Kumar Sharma and Jose Decena Sollano and Jian Sun and Tawesak Tanwandee and Alexander J. V. Thompson and Fang Wang and Guiqiang Wang and Lai Wei and Grace Lai‐Hung Wong and Vincent Wai Sun Wong and Eng Kiong Yeoh and Terry Cheuk‐Fung Yip and Ming‐Lung Yu and Wenhong Zhang and Hui Zhuang and Ching‐Lung Lai and Masao Omata and Shiv Kumar Sarin and George K.K. Lau and APASL Viral Elimination Taskforce},
  journal = {Hepatology International},
  year = {2026},
  month = jun,
  doi = {10.1007/s12072-026-11108-1},
  url = {https://doi.org/10.1007/s12072-026-11108-1},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - APASL clinical practice guidelines on the management of chronic hepatitis B infection: a 2026 update
AU  - Hong You
AU  - Rakhi Maiwall
AU  - Jing Chen
AU  - Sang Hoon Ahn
AU  - Kadir Dokmeci
AU  - 窦晓光
AU  - Manal El-Sayed
AU  - Jian-Gao Fan
AU  - Rino Gani
AU  - Zhiliang Gao
AU  - Jacob George
AU  - Hasmik Ghazinian
AU  - George Goh
AU  - Saeed Hamid
AU  - Jinlin Hou
AU  - Shang‐Chin Huang
AU  - Dong Ji
AU  - Jidong Jia
AU  - Tatsuo Kanda
AU  - Jia‐Horng Kao
AU  - Yoon Jun Kim
AU  - Cosmas Rinaldi A. Lesmana
AU  - Rosmawati Binti Mohamed
AU  - Qin Ning
AU  - Necati Ormeci
AU  - Motoyuki Otsuka
AU  - Diana Payawal
AU  - Pham Thanh Thuy
AU  - Keo Sailey
AU  - Manoj Kumar Sharma
AU  - Jose Decena Sollano
AU  - Jian Sun
AU  - Tawesak Tanwandee
AU  - Alexander J. V. Thompson
AU  - Fang Wang
AU  - Guiqiang Wang
AU  - Lai Wei
AU  - Grace Lai‐Hung Wong
AU  - Vincent Wai Sun Wong
AU  - Eng Kiong Yeoh
AU  - Terry Cheuk‐Fung Yip
AU  - Ming‐Lung Yu
AU  - Wenhong Zhang
AU  - Hui Zhuang
AU  - Ching‐Lung Lai
AU  - Masao Omata
AU  - Shiv Kumar Sarin
AU  - George K.K. Lau
AU  - APASL Viral Elimination Taskforce
PY  - 2026
DA  - 2026/06/27
JO  - Hepatology International
DO  - 10.1007/s12072-026-11108-1
UR  - https://doi.org/10.1007/s12072-026-11108-1
AB  - Globally, especially in the Asia Pacific region, chronic hepatitis B infection has led to an undesirable escalating morbidity and mortality with acute-on chronic liver failure, end-staged liver cirrhosis, and hepatocellular carcinoma. This has happened despite the past four decades of major scientific advances made in screening methods, vaccination strategies, highly effective low-cost anti-viral therapies, and surveillance strategies for early detection of hepatocellular carcinoma. To address this health threat, APASL has formed a Viral Elimination Taskforce to unite key opinion leaders from its member countries and regions. The ongoing shifts in hepatitis B epidemiology, socioeconomic changes, and advancements in technology are taken into consideration. With the conjoint efforts of all the members of the APASL Viral Elimination Taskforce, these clinical practice guidelines have been formulated aiming to facilitate healthcare professionals, policy-makers, and patients in making practical and cost-effective management decisions for chronic hepatitis B infection. Altogether, it provides recommendations in 13 major areas related to screening, vaccination, treatment, and HCC surveillance. The implementation of these clinical practice guidelines represents major APASL effort toward elimination of the disease burden due to chronic hepatitis B infection in Asia Pacific region.
SN  - 1936-0533
SN  - 1936-0541
ER  -