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Peer-reviewedLicence not statedNature

Spatiotemporal transcriptome atlas of human embryos after gastrulation

  • Jiexue Pan1,2
  • Yuejiao Li3,4,5,6
  • Zhongliang Lin7,8,9,10,11
  • Qing Lan4,5,6
  • Ying Zhang12,4,5,10,13
  • Huixi Chen2,13,6
  • Shengwei Sui1,6
  • Man Zhai4,5,1,10
  • Gaochen Zhang1,2,10
  • Yi Cheng1,2,10
  • Yunhui Tang1,2
  • Qingchen Wang1,6
43 more authors
  • Yue Xu1,2,6
  • Guoling Li14,1,10
  • Chunyan Xu1,2,4,5,10
  • Haoqi Yan15,4,5,13
  • Yiting Mao7,8,9,1,2,16
  • Xingxia Wang4,5,16
  • Haiqian Lu4,5,13
  • Yiping Zhu15,4,5,17
  • Qinfang Chen13,17
  • Yichun Guan16,1
  • Nan Meng16,6
  • Chang Wang4,5,6
  • Haiqian Lu13,6
  • Xiangjuan Li17,6
  • Tingting Zheng17,6
  • Xiaoying Yao1,6
  • Tingyu Yang15,5,9,10,11
  • Xuan Chen15,5,1
  • Qiuyu Qin4,5,1,10
  • Bin Jiang4,5,1,10
  • Yuxing Ren4,5,1,10
  • Xinmei Liu1,2,6,18
  • Yuxin Zhang12,4,5,1
  • Minghui Yu4,5,6,19
  • Lifang Wang4,1,10
  • Yanrong Wei15,4,6,20
  • Meiqi Luo4,5,9,1,10,11
  • Ji Nancuo5
  • Fuhe Ma4,5
  • Ziwei Wang12
  • Zhihua Ou21
  • Ying Lei4
  • Xin Jin5
  • Jian‐Zhong Sheng7,8,9
  • Congjian Xu1,2,4,5
  • Yanting Wu1,2
  • Chenming Xu1,2,4,5
  • Lijian Zhao22,23
  • Hongbo Yang24
  • Ya Ming Gao25,26,27
  • Guolian Ding28,29,30
  • Xun Xu31,32
  • Hefeng Huang33,34,35,36,37,38
38 affiliations
  1. 1Obstetrics and Gynecology Hospital, Institute of Reproduction and Development, Fudan University, Shanghai, China
  2. 2Shanghai Key Laboratory of Reproduction and Development, Shanghai, China
  3. 3BGI College & Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China
  4. 4State Key Laboratory of Genome and Multi-omics Technologies, BGI Research, Hangzhou, China
  5. 5State Key Laboratory of Genome and Multi-omics Technologies, BGI Research, Shenzhen, China
  6. 6BGI-Shenzhen, Shenzhen, China
  7. 7Department of Obstetrics and Gynecology, Center for Reproductive Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University School of Medicine, Yiwu, China
  8. 8Institute of Medical Genetics and Development, Zhejiang University, Hangzhou, China
  9. 9Key Laboratory of Reproductive Genetics (Ministry of Education), Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China
  10. 10Research Units of Embryo Original Diseases, Chinese Academy of Medical Sciences (No. 2019RU06), Shanghai, China
  11. 11The Fourth Affiliated Hospital, International Institutes of Medicine, Zhejiang University School of Medicine, Yiwu, China
  12. 12BGI Research, Wuhan, China
  13. 13The International Peace Maternal and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
  14. 14Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, China
  15. 15College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China
  16. 16The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China
  17. 17Hangzhou Women's Hospital, Hangzhou, China
  18. 18Medical Technology College of Hebei Medical University, Shijiazhuang, China
  19. 19Shenzhen Engineering Laboratory for Birth Defects Screening, Shenzhen, China
  20. 20Guangdong Provincial Key Laboratory of Genome Read and Write, Shenzhen, China
  21. 21BGI Research, Beijing, China
  22. 22BGI Genomics, BGI-Shenzhen, Shenzhen, China. [email protected]
  23. 23Medical Technology College of Hebei Medical University, Shijiazhuang, China. [email protected]
  24. 24Obstetrics and Gynecology Hospital, Institute of Reproduction and Development, Fudan University, Shanghai, China. [email protected]
  25. 25Shanxi Medical University - BGI Collaborative Center for Future Medicine, Shanxi Medical University, Taiyuan, China. [email protected]
  26. 26Shenzhen Engineering Laboratory for Birth Defects Screening, Shenzhen, China. [email protected]
  27. 27State Key Laboratory of Genome and Multi-omics Technologies, BGI Research, Shenzhen, China. [email protected]
  28. 28BGI College & Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China. [email protected]
  29. 29Obstetrics and Gynecology Hospital, Institute of Reproduction and Development, Fudan University, Shanghai, China. [email protected]
  30. 30Shanghai Key Laboratory of Reproduction and Development, Shanghai, China. [email protected]
  31. 31Guangdong Provincial Key Laboratory of Genome Read and Write, Shenzhen, China. [email protected]
  32. 32State Key Laboratory of Genome and Multi-omics Technologies, BGI Research, Shenzhen, China. [email protected]
  33. 33Department of Obstetrics and Gynecology, Center for Reproductive Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University School of Medicine, Yiwu, China. [email protected]
  34. 34Institute of Medical Genetics and Development, Zhejiang University, Hangzhou, China. [email protected]
  35. 35Key Laboratory of Reproductive Genetics (Ministry of Education), Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China. [email protected]
  36. 36Obstetrics and Gynecology Hospital, Institute of Reproduction and Development, Fudan University, Shanghai, China. [email protected]
  37. 37Shanghai Key Laboratory of Reproduction and Development, Shanghai, China. [email protected]
  38. 38The International Peace Maternal and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. [email protected]
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Cite

BibTeXRIS
BibTeX
@article{pan2026spatiotemporal,
  title = {{Spatiotemporal transcriptome atlas of human embryos after gastrulation}},
  author = {Jiexue Pan and Yuejiao Li and Zhongliang Lin and Qing Lan and Ying Zhang and Huixi Chen and Shengwei Sui and Man Zhai and Gaochen Zhang and Yi Cheng and Yunhui Tang and Qingchen Wang and Yue Xu and Guoling Li and Chunyan Xu and Haoqi Yan and Yiting Mao and Xingxia Wang and Haiqian Lu and Yiping Zhu and Qinfang Chen and Yichun Guan and Nan Meng and Chang Wang and Haiqian Lu and Xiangjuan Li and Tingting Zheng and Xiaoying Yao and Tingyu Yang and Xuan Chen and Qiuyu Qin and Bin Jiang and Yuxing Ren and Xinmei Liu and Yuxin Zhang and Minghui Yu and Lifang Wang and Yanrong Wei and Meiqi Luo and Ji Nancuo and Fuhe Ma and Ziwei Wang and Zhihua Ou and Ying Lei and Xin Jin and Jian‐Zhong Sheng and Congjian Xu and Yanting Wu and Chenming Xu and Lijian Zhao and Hongbo Yang and Ya Ming Gao and Guolian Ding and Xun Xu and Hefeng Huang},
  journal = {Nature},
  year = {2026},
  month = may,
  doi = {10.1038/s41586-026-10545-0},
  url = {https://doi.org/10.1101/2023.04.22.537909},
}
RIS
TY  - JOUR
TI  - Spatiotemporal transcriptome atlas of human embryos after gastrulation
AU  - Jiexue Pan
AU  - Yuejiao Li
AU  - Zhongliang Lin
AU  - Qing Lan
AU  - Ying Zhang
AU  - Huixi Chen
AU  - Shengwei Sui
AU  - Man Zhai
AU  - Gaochen Zhang
AU  - Yi Cheng
AU  - Yunhui Tang
AU  - Qingchen Wang
AU  - Yue Xu
AU  - Guoling Li
AU  - Chunyan Xu
AU  - Haoqi Yan
AU  - Yiting Mao
AU  - Xingxia Wang
AU  - Haiqian Lu
AU  - Yiping Zhu
AU  - Qinfang Chen
AU  - Yichun Guan
AU  - Nan Meng
AU  - Chang Wang
AU  - Haiqian Lu
AU  - Xiangjuan Li
AU  - Tingting Zheng
AU  - Xiaoying Yao
AU  - Tingyu Yang
AU  - Xuan Chen
AU  - Qiuyu Qin
AU  - Bin Jiang
AU  - Yuxing Ren
AU  - Xinmei Liu
AU  - Yuxin Zhang
AU  - Minghui Yu
AU  - Lifang Wang
AU  - Yanrong Wei
AU  - Meiqi Luo
AU  - Ji Nancuo
AU  - Fuhe Ma
AU  - Ziwei Wang
AU  - Zhihua Ou
AU  - Ying Lei
AU  - Xin Jin
AU  - Jian‐Zhong Sheng
AU  - Congjian Xu
AU  - Yanting Wu
AU  - Chenming Xu
AU  - Lijian Zhao
AU  - Hongbo Yang
AU  - Ya Ming Gao
AU  - Guolian Ding
AU  - Xun Xu
AU  - Hefeng Huang
PY  - 2026
DA  - 2026/05/27
JO  - Nature
DO  - 10.1038/s41586-026-10545-0
UR  - https://doi.org/10.1101/2023.04.22.537909
SN  - 0028-0836
SN  - 1476-4687
ER  -