A Biotinylated Heptapeptide Containing a D-Amino Acid Suppresses Both IgE-Dependent and -Independent Allergic Edema in Mice
Abstract
We previously found that, among three biotinylated heptapeptides (Peptide 1, Peptide 2, and Peptide 3) derived from the amino acid sequence of Asp-hemolysin, a protein toxin produced by Aspergillus fumigatus, Peptide 2, which contains a d-amino acid, exhibits potent anti-allergic activity in vitro and in vivo. In this study, we evaluated the effects of Peptide 2 on immunoglobulin E (IgE)-dependent allergic edema induced by ovalbumin (OVA) in OVA-specific IgE transgenic mice, IgE-independent allergic edema induced by compound 48/80 (C48/80), and nonallergic inflammatory edema induced by histamine, serotonin, bradykinin, zymosan A, and λ-carrageenan. Peptide 2 significantly suppressed both OVA-IgE- and C48/80-induced paw edema, indicating inhibitory effects on both IgE-dependent and -independent allergic responses. Peptide 2 also dose-dependently inhibited histamine-induced edema but did not affect serotonin-, bradykinin-, zymosan A-, or λ-carrageenan-induced edema. These findings indicate that Peptide 2 modulates IgE-dependent and -independent allergic responses involving mast cell activation and histamine-related pathways and may be a candidate for the development of selective anti-allergic agents.
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BibTeX
@article{ohira2026biotinylated,
title = {{A Biotinylated Heptapeptide Containing a D-Amino Acid Suppresses Both IgE-Dependent and -Independent Allergic Edema in Mice}},
author = {Makoto Ohira and Hana Yuki and Miu Tsumuraya and Erika Nozaki and Ryoka Nukimizu and Tadahiro Etoh and Daisuke Uta and Tsukasa Matsumoto and Akira Sato},
journal = {Biological and Pharmaceutical Bulletin},
year = {2026},
month = oct,
doi = {10.1248/bpb.b26-00370},
url = {https://www.jstage.jst.go.jp/article/bpb/49/10/49_b26-00370/_article},
note = {CC BY-NC},
}
RIS
TY - JOUR
TI - A Biotinylated Heptapeptide Containing a D-Amino Acid Suppresses Both IgE-Dependent and -Independent Allergic Edema in Mice
AU - Makoto Ohira
AU - Hana Yuki
AU - Miu Tsumuraya
AU - Erika Nozaki
AU - Ryoka Nukimizu
AU - Tadahiro Etoh
AU - Daisuke Uta
AU - Tsukasa Matsumoto
AU - Akira Sato
PY - 2026
DA - 2026/10/02
JO - Biological and Pharmaceutical Bulletin
DO - 10.1248/bpb.b26-00370
UR - https://www.jstage.jst.go.jp/article/bpb/49/10/49_b26-00370/_article
AB - We previously found that, among three biotinylated heptapeptides (Peptide 1, Peptide 2, and Peptide 3) derived from the amino acid sequence of Asp-hemolysin, a protein toxin produced by Aspergillus fumigatus, Peptide 2, which contains a d-amino acid, exhibits potent anti-allergic activity in vitro and in vivo. In this study, we evaluated the effects of Peptide 2 on immunoglobulin E (IgE)-dependent allergic edema induced by ovalbumin (OVA) in OVA-specific IgE transgenic mice, IgE-independent allergic edema induced by compound 48/80 (C48/80), and nonallergic inflammatory edema induced by histamine, serotonin, bradykinin, zymosan A, and λ-carrageenan. Peptide 2 significantly suppressed both OVA-IgE- and C48/80-induced paw edema, indicating inhibitory effects on both IgE-dependent and -independent allergic responses. Peptide 2 also dose-dependently inhibited histamine-induced edema but did not affect serotonin-, bradykinin-, zymosan A-, or λ-carrageenan-induced edema. These findings indicate that Peptide 2 modulates IgE-dependent and -independent allergic responses involving mast cell activation and histamine-related pathways and may be a candidate for the development of selective anti-allergic agents.
SN - 1347-5215
SN - 0918-6158
ER -