The COX2-PGE2-PKA axis suppresses antiviral immunity by inhibiting mtDNA-dependent STING activation

c-FLIP loss links arrest of gene expression to TNFα-dependent antiviral guard immunity
Matthew Sonnett, Sanne Boersma, Madeline E. Ward +8
Proceedings of the National Academy of Sciences of the United States of America22 Oct 2026Peer-reviewedCC BY 4.0Full textSystems & synthetic biologyPMC
Activation of KCa3.1 K⁺ Channel Suppresses COX2- and ARG1-Dependent Immunosuppressive Metabolic Programs in THP-1-Derived M₂-like Macrophages.
Junko Kajikuri, Ayano Kitahara, Miki Matsui +5
International journal of molecular sciences23 Sep 2026Peer-reviewedCC BYFull textImmunologyEurope PMC
The orphan receptor IL-17RD is a negative regulator of RIG-I-like receptor-dependent antiviral innate immunity and restrains SARS-CoV-2-induced lung inflammation
F. El-Mortada, J. Roy, C. Girondel +11
bioRxiv1 Sep 2026PreprintCC BY-NC-NDFull textMicrobiologybioRxiv
Antiviral immunity via telomerase-like reverse transcription in bacteria
Stephen Tang, Josephine L. Ramirez, Qixiang He +11
Nature12 Oct 2026Peer-reviewedLicence not statedFull text9 citedEcology MicrobiologyOpenAlex
Eicosa-11Z,14Z,17Z-Trienoic Acid Suppresses Melanogenesis by Inhibiting Intracellular MITF/Tyrosinase Axis.
Kyoung Mi Moon, Min-Kyeong Lee, Su-Yeon Park +2
Journal of microbiology and biotechnology8 Oct 2026Peer-reviewedCC BYFull textCell biologyEurope PMC

Cite

BibTeX

@article{vo2026cox2pge2pka,
  title = {{The COX2-PGE2-PKA axis suppresses antiviral immunity by inhibiting mtDNA-dependent STING activation}},
  author = {Pham Thuy Tien Vo and Julien Cicero and Zichen Wang and Hiroyuki Hakozaki and Thomas S. Hoang and Sendi Rafael Adame-Garcia and Dana J. Ramms and Kuniaki Sato and Erica Stevenson and Yuan Zhou and Katie Fan and Juliette A. Bokor and Vasiliya Kril and Cara Schiavon and Scott B. Biering and Danielle L. Swaney and Nevan J. Krogan and Johannes Schöneberg and Uri Manor and J. Silvio Gutkind},
  journal = {Cell Reports},
  year = {2026},
  month = oct,
  doi = {10.1016/j.celrep.2026.118154},
  url = {https://linkinghub.elsevier.com/retrieve/pii/S2211124726012337},
  note = {CC BY 4.0},
}

RIS

TY  - JOUR
TI  - The COX2-PGE2-PKA axis suppresses antiviral immunity by inhibiting mtDNA-dependent STING activation
AU  - Pham Thuy Tien Vo
AU  - Julien Cicero
AU  - Zichen Wang
AU  - Hiroyuki Hakozaki
AU  - Thomas S. Hoang
AU  - Sendi Rafael Adame-Garcia
AU  - Dana J. Ramms
AU  - Kuniaki Sato
AU  - Erica Stevenson
AU  - Yuan Zhou
AU  - Katie Fan
AU  - Juliette A. Bokor
AU  - Vasiliya Kril
AU  - Cara Schiavon
AU  - Scott B. Biering
AU  - Danielle L. Swaney
AU  - Nevan J. Krogan
AU  - Johannes Schöneberg
AU  - Uri Manor
AU  - J. Silvio Gutkind
PY  - 2026
DA  - 2026/10/01
JO  - Cell Reports
DO  - 10.1016/j.celrep.2026.118154
UR  - https://linkinghub.elsevier.com/retrieve/pii/S2211124726012337
SN  - 2211-1247
ER  -

Related

Cite