Choroidal vascularity index changes in proliferative and nonproliferative macular telangiectasia type 2

Abstract

PURPOSE: This study aimed to evaluate the choroidal vascularity index (CVI) in patients with nonproliferative and proliferative macular telangiectasia type 2 (MacTel-2) compared to healthy controls, assess the impact of ellipsoid zone (EZ) disruption on CVI, and determine whether CVI measurements vary with different binarization areas. MATERIALS AND METHODS: CVIs from MacTel-2 eyes were compared to those of healthy controls. MacTel-2 eyes were categorized as proliferative or nonproliferative and further subdivided by the presence or absence of EZ disruption. CVI was measured in three regions: 1500 µm, 4000 µm, and the total macular choroidal area (TCA). Statistical analyses included paired samples t-tests, independent samples t-tests, and Mann–Whitney U-tests. P < 0.05 was considered statistically significant. RESULTS: This study included 90 eyes each from MacTel-2 patients and healthy controls. CVIs did not significantly differ between eyes with and without EZ disruption in either MacTel-2 group (P > 0.05). CVIs beneath EZ-disrupted areas were also comparable to intact zones (P > 0.05). No significant CVI difference was observed between nonproliferative and proliferative MacTel-2 eyes (P > 0.1). However, both the groups had significantly lower CVIs than healthy controls across all measured areas (P < 0.001 for nonproliferative and P < 0.05 for proliferative). CVI values were consistent across all binarization areas (P > 0.1). CONCLUSION: EZ disruption does not affect CVI. CVIs were similar in nonproliferative and proliferative MacTel-2, both lower than in healthy eyes. CVI also remained consistent across different binarization areas, confirming its reliability regardless of area size.

Acute Effects of Caffeine on Choroidal Structure and Vascularity in Healthy Young Adults: A Time-Resolved OCT and OCT-Angiography Study
Eleonora D’Aniello, Livio Vitiello, Maddalena De Bernardo +6
Nutrients1 Oct 2026Peer-reviewedCC BY 4.0Full textNutritionCrossrefEurope PMC
Comparison of Optical Coherence Tomography Biomarkers in Nonproliferative and Proliferative Diabetic Retinopathy: Marmasia Study Group Report No. 2
Işılay Özsoy Saygın, Esra Kumral Türkseven, Fatih Bilgehan Kaplan +19
Turkish Journal of Ophthalmology1 Oct 2026Peer-reviewedCC BY-NC-ND 4.0Full textGeneral medicinePMCEurope PMC
Choroidal thickness postural changes in healthy young adults
Maddalena De Bernardo, Marco Gioia, Andrea Valerio Marino +2
Scientific Reports1 Jul 2026Peer-reviewedCC BYFull textGeneral medicineDOAJ
Longitudinal Changes in Choroidal Thickness Across the Eye in Young Children With Premyopia.
Karen Flores, Aidan McCullough, Zhihui She +2
Investigative ophthalmology & visual science1 Oct 2026Peer-reviewedCC BY-NC-NDFull textEpidemiology & public healthEurope PMC
Retinal and Choroidal Microvascular Changes Across the Migraine Attack Cycle: A Systematic Review and Exploratory Quantitative Synthesis
Abdullah Q Banimohammad, Yael Reingold, Zaid A Al-Samarat +9
Cureus1 Oct 2026Peer-reviewedCC BYFull textEpidemiology & public health NeurologyEurope PMCPMC

Cite

BibTeX RIS

BibTeX

@article{ercan2026choroidal,
  title = {{Choroidal vascularity index changes in proliferative and nonproliferative macular telangiectasia type 2}},
  author = {Zeynep Eylul Ercan and Gulsah Gokgoz and İmren Akkoyun and Gursel Yilmaz},
  journal = {Taiwan Journal of Ophthalmology},
  year = {2026},
  month = jul,
  doi = {10.4103/tjo.tjo-d-25-00092},
  url = {https://doi.org/10.4103/tjo.tjo-d-25-00092},
  note = {CC BY-NC-ND},
}

RIS

TY  - JOUR
TI  - Choroidal vascularity index changes in proliferative and nonproliferative macular telangiectasia type 2
AU  - Zeynep Eylul Ercan
AU  - Gulsah Gokgoz
AU  - İmren Akkoyun
AU  - Gursel Yilmaz
PY  - 2026
DA  - 2026/07/01
JO  - Taiwan Journal of Ophthalmology
DO  - 10.4103/tjo.tjo-d-25-00092
UR  - https://doi.org/10.4103/tjo.tjo-d-25-00092
AB  - PURPOSE: This study aimed to evaluate the choroidal vascularity index (CVI) in patients with nonproliferative and proliferative macular telangiectasia type 2 (MacTel-2) compared to healthy controls, assess the impact of ellipsoid zone (EZ) disruption on CVI, and determine whether CVI measurements vary with different binarization areas. MATERIALS AND METHODS: CVIs from MacTel-2 eyes were compared to those of healthy controls. MacTel-2 eyes were categorized as proliferative or nonproliferative and further subdivided by the presence or absence of EZ disruption. CVI was measured in three regions: 1500 µm, 4000 µm, and the total macular choroidal area (TCA). Statistical analyses included paired samples t-tests, independent samples t-tests, and Mann–Whitney U-tests. P < 0.05 was considered statistically significant. RESULTS: This study included 90 eyes each from MacTel-2 patients and healthy controls. CVIs did not significantly differ between eyes with and without EZ disruption in either MacTel-2 group (P > 0.05). CVIs beneath EZ-disrupted areas were also comparable to intact zones (P > 0.05). No significant CVI difference was observed between nonproliferative and proliferative MacTel-2 eyes (P > 0.1). However, both the groups had significantly lower CVIs than healthy controls across all measured areas (P < 0.001 for nonproliferative and P < 0.05 for proliferative). CVI values were consistent across all binarization areas (P > 0.1). CONCLUSION: EZ disruption does not affect CVI. CVIs were similar in nonproliferative and proliferative MacTel-2, both lower than in healthy eyes. CVI also remained consistent across different binarization areas, confirming its reliability regardless of area size.
SN  - 2211-5056
SN  - 2211-5072
ER  -

Abstract

Related

Cite