Matrix bound nanovesicles from decellularized pericardium facilitate angiogenesis
- 1Laboratory for Biomaterials and Bioengineering, Canada Research Chair Tier I for the Innovation in Surgery, Department of Min-Met-Materials Engineering and Regenerative Medicine, CHU de Quebec Research Center, Laval University , , ,
- 2Department of Health Sciences, University of Piemonte Orientale , ,
- 3Settore Centri di Ricerca e Infrastrutture di Ateneo e Laboratori - Polo di Novara, University of Piemonte Orientale , ,
Abstract
Therapeutic angiogenesis is a regenerative medicine approach which aims to induce revascularization for tissue repair. Among the existing strategies used to promote angiogenesis, biomaterials derived from decellularized tissues and composed of extracellular matrix (dECM) possess intrinsic angiogenic and regenerative potential. Recently, a bioactive component of such ECM materials has been identified; specifically, matrix bound nanovesicles (MBV). MBV have been shown to possess highly bioactive and tissue-specific cargo, and the ability to induce a potent immunomodulatory and regenerative response. However, their angiogenic potential has not been studied yet. Herein, the angiogenic properties of MBV derived from bovine pericardia dECM is evaluated. MBV show cytocompatibility toward endothelial cells, enhancing their functional phenotype and inducing the expression of angiogenic markers. In the presence of MBV, endothelial cells form three-dimensional monolayered endothelial vessel-like structures in tube formation assay. MBV also enhance endothelial sprouting in aortic ring assay. Finally, in hind limb ischemia in vivo model, MBV prevent tissue necrosis and restore vascularization and tissue function. These results demonstrate the angiogenic potential of MBV from pericardia ECM and represent a promising approach for therapeutic angiogenesis in regenerative medicine applications.
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BibTeX
@article{francesco2026matrix,
title = {{Matrix bound nanovesicles from decellularized pericardium facilitate angiogenesis}},
author = {Dalila Di Francesco and Carolina Di Varsavia and Irene Regano and Luca Di Nunno and Simona Casarella and Nausicaa Clemente and Diego Mantovani and Francesca Boccafoschi},
journal = {Frontiers in bioengineering and biotechnology},
year = {2026},
month = oct,
doi = {10.3389/fbioe.2026.1980409},
url = {https://europepmc.org/article/PMC/PMC13720949},
note = {CC BY},
}
RIS
TY - JOUR
TI - Matrix bound nanovesicles from decellularized pericardium facilitate angiogenesis
AU - Dalila Di Francesco
AU - Carolina Di Varsavia
AU - Irene Regano
AU - Luca Di Nunno
AU - Simona Casarella
AU - Nausicaa Clemente
AU - Diego Mantovani
AU - Francesca Boccafoschi
PY - 2026
DA - 2026/10/16
JO - Frontiers in bioengineering and biotechnology
DO - 10.3389/fbioe.2026.1980409
UR - https://europepmc.org/article/PMC/PMC13720949
AB - Therapeutic angiogenesis is a regenerative medicine approach which aims to induce revascularization for tissue repair. Among the existing strategies used to promote angiogenesis, biomaterials derived from decellularized tissues and composed of extracellular matrix (dECM) possess intrinsic angiogenic and regenerative potential. Recently, a bioactive component of such ECM materials has been identified; specifically, matrix bound nanovesicles (MBV). MBV have been shown to possess highly bioactive and tissue-specific cargo, and the ability to induce a potent immunomodulatory and regenerative response. However, their angiogenic potential has not been studied yet. Herein, the angiogenic properties of MBV derived from bovine pericardia dECM is evaluated. MBV show cytocompatibility toward endothelial cells, enhancing their functional phenotype and inducing the expression of angiogenic markers. In the presence of MBV, endothelial cells form three-dimensional monolayered endothelial vessel-like structures in tube formation assay. MBV also enhance endothelial sprouting in aortic ring assay. Finally, in hind limb ischemia in vivo model, MBV prevent tissue necrosis and restore vascularization and tissue function. These results demonstrate the angiogenic potential of MBV from pericardia ECM and represent a promising approach for therapeutic angiogenesis in regenerative medicine applications.
SN - 2296-4185
ER -