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Peer-reviewedCC BY-NC-ND 4.0Journal of Gastroenterology and Hepatology

Postelectroacupuncture Fecal Microbiota Transplantation (post‐EA FMT) Regulates Gastrointestinal Hormones in Functional Dyspepsia Rats Is Associated With Modulation of the Intestinal Microbiota‐Bile Acid Metabolic Pathway

  • Yong‐Li Han1
  • Dong‐Fang Shang2
  • Juli Tang3
  • Dong‐Dong Yu4
  • Liang‐Yu Zhang5
  • Jing Zhou6
  • Qing‐Bo Wang1
6 affiliations
  1. 1Acupuncture Department The First Affiliated Hospital of Henan University of CM Zhengzhou Henan Province China
  2. 2Department of Hepatology and Gastroenterology The First Affiliated Hospital of Henan University of CM Zhengzhou Henan Province China
  3. 3College of Life Sciences Shanghai Normal University Shanghai China
  4. 4Institute of Acupuncture and Tuina Henan University of Chinese Medicine Zhengzhou Henan Province China
  5. 5Department of Spleen and Stomach The Second Affiliated Hospital of Nanjing University of Chinese Medicine Nanjing Jiangsu Province China
  6. 6Department of Radiology Henan Provincial People's Hospital and Zhengzhou University People's Hospital and Henan Provincial Key Laboratory of Neurological Disease Imaging Diagnosis and Research Zhengzhou Henan Province China
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Abstract

Background: Electroacupuncture (EA) reshapes intestinal flora; whether post‐EA fecal microbiota transplantation (post‐EA FMT) regulates gastrointestinal hormones via the gut microbiota–bile acid (BA) pathway remains unclear.

Methods: Sham EA (SEA) served as control. Gastrointestinal hormones/motility were assessed post‐EA. Fecal microbiota from EA/SEA‐treated rats were transplanted into pseudo‐germ‐free (PGF) rats. Gut microbiota and BA profiles were analyzed.

Results: EA downregulated Ghrelin, PYY, GLP‐1, upregulated CCK, and enhanced motility in FD rats. Post‐EA FMT increased Firmicutes/Bacteroidetes (phylum); upregulated Lactobacillus, Prevotella, [Prevotella] (genus); decreased Blautia, Proteobacteria, Bacteroides; reduced multiple BAs (including TUDCA/TCDCA). TUDCA/TCDCA showed strong positive correlation.

Conclusions: The gut microbiota‐BA pathway associates with post‐EA FMT's beneficial regulation of gastrointestinal hormones. The gut microbiota–BA pathway is associated with post‐EA FMT's beneficial regulation of gastrointestinal hormones. The gut microbiota–BA pathway is associated with post‐EA FMT's beneficial regulation of gastrointestinal hormones. The Lactobacillus/TUDCA/TCDCA axis represents a candidate pathway that may contribute to this process (validation pending). Current findings indicate strong correlations, not causality.

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Cite

BibTeXRIS
BibTeX
@article{han2026postelectroacupuncture,
  title = {{Postelectroacupuncture Fecal Microbiota Transplantation (post‐EA FMT) Regulates Gastrointestinal Hormones in Functional Dyspepsia Rats Is Associated With Modulation of the Intestinal Microbiota‐Bile Acid Metabolic Pathway}},
  author = {Yong‐Li Han and Dong‐Fang Shang and Juli Tang and Dong‐Dong Yu and Liang‐Yu Zhang and Jing Zhou and Qing‐Bo Wang},
  journal = {Journal of Gastroenterology and Hepatology},
  year = {2026},
  month = sep,
  doi = {10.1111/jgh.70744},
  url = {https://doi.org/10.1111/jgh.70744},
  note = {CC BY-NC-ND 4.0},
}
RIS
TY  - JOUR
TI  - Postelectroacupuncture Fecal Microbiota Transplantation (post‐EA FMT) Regulates Gastrointestinal Hormones in Functional Dyspepsia Rats Is Associated With Modulation of the Intestinal Microbiota‐Bile Acid Metabolic Pathway
AU  - Yong‐Li Han
AU  - Dong‐Fang Shang
AU  - Juli Tang
AU  - Dong‐Dong Yu
AU  - Liang‐Yu Zhang
AU  - Jing Zhou
AU  - Qing‐Bo Wang
PY  - 2026
DA  - 2026/09/15
JO  - Journal of Gastroenterology and Hepatology
DO  - 10.1111/jgh.70744
UR  - https://doi.org/10.1111/jgh.70744
AB  - Background: Electroacupuncture (EA) reshapes intestinal flora; whether post‐EA fecal microbiota transplantation (post‐EA FMT) regulates gastrointestinal hormones via the gut microbiota–bile acid (BA) pathway remains unclear.  Methods: Sham EA (SEA) served as control. Gastrointestinal hormones/motility were assessed post‐EA. Fecal microbiota from EA/SEA‐treated rats were transplanted into pseudo‐germ‐free (PGF) rats. Gut microbiota and BA profiles were analyzed.  Results: EA downregulated Ghrelin, PYY, GLP‐1, upregulated CCK, and enhanced motility in FD rats. Post‐EA FMT increased Firmicutes/Bacteroidetes (phylum); upregulated Lactobacillus, Prevotella, [Prevotella] (genus); decreased Blautia, Proteobacteria, Bacteroides; reduced multiple BAs (including TUDCA/TCDCA). TUDCA/TCDCA showed strong positive correlation.  Conclusions: The gut microbiota‐BA pathway associates with post‐EA FMT's beneficial regulation of gastrointestinal hormones. The gut microbiota–BA pathway is associated with post‐EA FMT's beneficial regulation of gastrointestinal hormones. The gut microbiota–BA pathway is associated with post‐EA FMT's beneficial regulation of gastrointestinal hormones. The Lactobacillus/TUDCA/TCDCA axis represents a candidate pathway that may contribute to this process (validation pending). Current findings indicate strong correlations, not causality.
SN  - 0815-9319
SN  - 1440-1746
ER  -