Emerging links between TLR4 signaling and ferroptosis in heart failure
- 1The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine) , ,
- 2Graduate School, Beijing University of Chinese Medicine , ,
- 3First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center of Chinese Medicine Acupuncture and Moxibustion , ,
Abstract
Iron is an essential nutrient for living organisms, and the maintenance of its homeostatic balance within the body is a critical factor in ensuring normal physiological functions. Cardiomyocyte ferroptosis has emerged as a potential contributor to heart failure progression, involving complex regulatory mechanisms that remain incompletely understood. While the TLR4 signaling pathway was traditionally regarded as a therapeutic target for chronic inflammatory conditions, emerging evidence indicates that its activation may contribute to ferroptosis in cardiomyocytes. The proposed mechanisms through which TLR4 signaling may regulate cardiomyocyte ferroptosis are systematically summarized, and several therapeutic strategies targeting TLR4-associated ferroptosis are evaluated. Furthermore, promising avenues for future investigation are discussed, with particular emphasis on the need for direct mechanistic validation in cardiomyocytes and in vivo models, which may ultimately inform novel therapeutic strategies for heart failure.
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BibTeX
@article{wang2026emerging,
title = {{Emerging links between TLR4 signaling and ferroptosis in heart failure}},
author = {Ci Wang and Xiangyuan Huang and Zeyu Zhang and Ying Hu and Dongming Lin and Shuwei Huang},
journal = {Frontiers in pharmacology},
year = {2026},
month = oct,
doi = {10.3389/fphar.2026.1909522},
url = {https://europepmc.org/article/PMC/PMC13668518},
note = {CC BY},
}
RIS
TY - JOUR
TI - Emerging links between TLR4 signaling and ferroptosis in heart failure
AU - Ci Wang
AU - Xiangyuan Huang
AU - Zeyu Zhang
AU - Ying Hu
AU - Dongming Lin
AU - Shuwei Huang
PY - 2026
DA - 2026/10/01
JO - Frontiers in pharmacology
DO - 10.3389/fphar.2026.1909522
UR - https://europepmc.org/article/PMC/PMC13668518
AB - Iron is an essential nutrient for living organisms, and the maintenance of its homeostatic balance within the body is a critical factor in ensuring normal physiological functions. Cardiomyocyte ferroptosis has emerged as a potential contributor to heart failure progression, involving complex regulatory mechanisms that remain incompletely understood. While the TLR4 signaling pathway was traditionally regarded as a therapeutic target for chronic inflammatory conditions, emerging evidence indicates that its activation may contribute to ferroptosis in cardiomyocytes. The proposed mechanisms through which TLR4 signaling may regulate cardiomyocyte ferroptosis are systematically summarized, and several therapeutic strategies targeting TLR4-associated ferroptosis are evaluated. Furthermore, promising avenues for future investigation are discussed, with particular emphasis on the need for direct mechanistic validation in cardiomyocytes and in vivo models, which may ultimately inform novel therapeutic strategies for heart failure.
SN - 1663-9812
ER -