Peer-reviewedCC BYJournal of translational medicine
Alveolar organoids: from model systems to applications in respiratory diseases.
7 affiliations
- 1Beijing Tuberculosis and Thoracic Tumor Research Institute, Courtyard 1, No.9 Beiguan Street, Tongzhou District, Beijing, 101199, China.
- 2Department of Respiratory and Critical Care Medicine, Beijing Chest Hospital, Capital Medical University, Courtyard 1, No.9 Beiguan Street, Tongzhou District, Beijing, 101199, China.
- 3Department of Respiratory and Critical Care Medicine, Peking University Third Hospital, Peking University, Beijing, 100191, China.
- 4Beijing Tuberculosis and Thoracic Tumor Research Institute, Courtyard 1, No.9 Beiguan Street, Tongzhou District, Beijing, 101199, China. [email protected].
- 5Department of Respiratory and Critical Care Medicine, Beijing Chest Hospital, Capital Medical University, Courtyard 1, No.9 Beiguan Street, Tongzhou District, Beijing, 101199, China. [email protected].
- 6Beijing Tuberculosis and Thoracic Tumor Research Institute, Courtyard 1, No.9 Beiguan Street, Tongzhou District, Beijing, 101199, China. [email protected].
- 7Department of Respiratory and Critical Care Medicine, Beijing Chest Hospital, Capital Medical University, Courtyard 1, No.9 Beiguan Street, Tongzhou District, Beijing, 101199, China. [email protected].
Abstract
Organoid technology has emerged as a research hotspot in the biomedical field in recent years, providing important methodologies for disease modeling, drug screening, and regenerative medicine. Alveolar organoids serve as crucial models for studying respiratory diseases, and their technological evolution and application expansion reflect key advances in this field. This article systematically reviews the developmental history of organoids, provides an in-depth comparison of the applicability and limitations of different culture and characterization strategies for alveolar organoids, summarizes and critically analyzes alveolar organoid models established for common respiratory diseases, and offers perspectives on future directions in this area.
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BibTeX
@article{xing2026alveolar,
title = {{Alveolar organoids: from model systems to applications in respiratory diseases.}},
author = {Yuanfang Xing and Luyu Yang and Zhimin Cao and Dongchang Wang and Huan Ye},
journal = {Journal of translational medicine},
year = {2026},
month = jul,
doi = {10.1186/s12967-026-08616-x},
url = {https://europepmc.org/article/MED/42897657},
note = {CC BY},
}
RIS
TY - JOUR
TI - Alveolar organoids: from model systems to applications in respiratory diseases.
AU - Yuanfang Xing
AU - Luyu Yang
AU - Zhimin Cao
AU - Dongchang Wang
AU - Huan Ye
PY - 2026
DA - 2026/07/01
JO - Journal of translational medicine
DO - 10.1186/s12967-026-08616-x
UR - https://europepmc.org/article/MED/42897657
AB - Organoid technology has emerged as a research hotspot in the biomedical field in recent years, providing important methodologies for disease modeling, drug screening, and regenerative medicine. Alveolar organoids serve as crucial models for studying respiratory diseases, and their technological evolution and application expansion reflect key advances in this field. This article systematically reviews the developmental history of organoids, provides an in-depth comparison of the applicability and limitations of different culture and characterization strategies for alveolar organoids, summarizes and critically analyzes alveolar organoid models established for common respiratory diseases, and offers perspectives on future directions in this area.
SN - 1479-5876
ER -