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PreprintCC BYbioRxiv

RNA and proteins joined up at the origins of Life: Persistence is the point

  • M. Swailem1
  • K. Dill
  1. 1Stony Brook University
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Abstract

What drove nucleic acids (NA) into functional associations with proteins (PR) at the origins of Life? We reason from polymer physics and the Central Dogma that the fitness value of cooperating through a division of labor - NA for replication fidelity and PR for functional fitness - is much higher than for either polymer alone. Our model shows a Pareto Front, where NA and PR can bootstrap each other to achieve autocatalytic cooperativity towards biology.

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Cite

BibTeXRIS
BibTeX
@misc{swailem2026proteins,
  title = {{RNA and proteins joined up at the origins of Life: Persistence is the point}},
  author = {M. Swailem and K. Dill},
  howpublished = {bioRxiv},
  year = {2026},
  month = jul,
  doi = {10.64898/2026.07.09.737588},
  url = {https://www.biorxiv.org/content/10.64898/2026.07.09.737588v2},
  note = {CC BY},
}
RIS
TY  - UNPB
TI  - RNA and proteins joined up at the origins of Life: Persistence is the point
AU  - M. Swailem
AU  - K. Dill
PY  - 2026
DA  - 2026/07/09
PB  - bioRxiv
DO  - 10.64898/2026.07.09.737588
UR  - https://www.biorxiv.org/content/10.64898/2026.07.09.737588v2
AB  - What drove nucleic acids (NA) into functional associations with proteins (PR) at the origins of Life? We reason from polymer physics and the Central Dogma that the fitness value of cooperating through a division of labor - NA for replication fidelity and PR for functional fitness - is much higher than for either polymer alone. Our model shows a Pareto Front, where NA and PR can bootstrap each other to achieve autocatalytic cooperativity towards biology.
ER  -