Association Between Cilio-Lenticular Distance and Anterior Chamber Depth in Primary Angle-Closure Glaucoma
4 affiliations
- 1National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, China
- 2Wenzhou Medical University, Wenzhou, China
- 3Changsha Aier Eye Hospital, Changsha, Hunan Province, China
- 4Ophthalmology, University of California San Francisco, San Francisco, California, United States
Abstract
Purpose: To investigate the lens and ciliary spatial characteristics in primary angle-closure glaucoma (PACG) patients using ocular magnetic resonance imaging (MRI), aiming to elucidate the mechanism underlying PACG pathogenesis.
Methods: This is a cross-sectional observational case-control study that used a clinical 3.0T MRI with a specialized coil to acquire binocular images in the axial plane. Quantitative measurements were conducted to obtain anatomical parameters of the lens, ciliary body, and vitreous cavity, including lens equator diameter (LED), cilio-lenticular distance (CLD), ciliary to ciliary distance (CCD), vitreous cavity width, and vitreous cavity depth. Linear mixed effects models were used for statistical analysis.
Result: Twenty-five eyes of 13 PACG patients and 19 eyes of 10 healthy participants were enrolled in this study. The PACG group exhibited a statistically significant larger Sectional Area of Lens (33.72 ± 2.50 mm2 vs. 30.72 ± 2.42 mm2, P = 0.005), lower CCD (9.74 ± 0.45 mm vs. 10.41 ± 0.62 mm, P = 0.003), and lower CLD (0.51 ± 0.09 mm vs. 0.85 ± 0.17 mm, P < 0.001). No differences were found in LED and characteristic parameters of vitreous cavities. CLD demonstrated a high predictive performance for PACG (area under the curve [AUC] = 0.979), approaching that of the classical parameter anterior chamber depth (AUC = 0.993), with both showing statistical significance (P < 0.001).
Conclusions: A smaller CLD correlates with a shallow anterior chamber and indicates a more crowded ciliary-lens configuration, a crucial indictor of PACG.
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BibTeX
@article{lei2026association,
title = {{Association Between Cilio-Lenticular Distance and Anterior Chamber Depth in Primary Angle-Closure Glaucoma}},
author = {Changrong Lei and Jingjing Zuo and Haishuang Lin and Xuanli Zheng and Fengping Zhao and Yongzhen Yu and Nikhita Mummaneni and Kun Xiong and Huiyan Mao and Xiaojie Wang and Peijuan Wang and Yanqian Xie and Rongrong Le and Shaodan Zhang and Ying Han and Yuanbo Liang},
journal = {Investigative Ophthalmology \& Visual Science},
year = {2026},
month = oct,
doi = {10.1167/iovs.67.12.64},
url = {https://doi.org/10.1167/iovs.67.12.64},
note = {CC BY-NC-ND 4.0},
}
RIS
TY - JOUR
TI - Association Between Cilio-Lenticular Distance and Anterior Chamber Depth in Primary Angle-Closure Glaucoma
AU - Changrong Lei
AU - Jingjing Zuo
AU - Haishuang Lin
AU - Xuanli Zheng
AU - Fengping Zhao
AU - Yongzhen Yu
AU - Nikhita Mummaneni
AU - Kun Xiong
AU - Huiyan Mao
AU - Xiaojie Wang
AU - Peijuan Wang
AU - Yanqian Xie
AU - Rongrong Le
AU - Shaodan Zhang
AU - Ying Han
AU - Yuanbo Liang
PY - 2026
DA - 2026/10/26
JO - Investigative Ophthalmology & Visual Science
DO - 10.1167/iovs.67.12.64
UR - https://doi.org/10.1167/iovs.67.12.64
AB - Purpose: To investigate the lens and ciliary spatial characteristics in primary angle-closure glaucoma (PACG) patients using ocular magnetic resonance imaging (MRI), aiming to elucidate the mechanism underlying PACG pathogenesis. Methods: This is a cross-sectional observational case-control study that used a clinical 3.0T MRI with a specialized coil to acquire binocular images in the axial plane. Quantitative measurements were conducted to obtain anatomical parameters of the lens, ciliary body, and vitreous cavity, including lens equator diameter (LED), cilio-lenticular distance (CLD), ciliary to ciliary distance (CCD), vitreous cavity width, and vitreous cavity depth. Linear mixed effects models were used for statistical analysis. Result: Twenty-five eyes of 13 PACG patients and 19 eyes of 10 healthy participants were enrolled in this study. The PACG group exhibited a statistically significant larger Sectional Area of Lens (33.72 ± 2.50 mm2 vs. 30.72 ± 2.42 mm2, P = 0.005), lower CCD (9.74 ± 0.45 mm vs. 10.41 ± 0.62 mm, P = 0.003), and lower CLD (0.51 ± 0.09 mm vs. 0.85 ± 0.17 mm, P < 0.001). No differences were found in LED and characteristic parameters of vitreous cavities. CLD demonstrated a high predictive performance for PACG (area under the curve [AUC] = 0.979), approaching that of the classical parameter anterior chamber depth (AUC = 0.993), with both showing statistical significance (P < 0.001). Conclusions: A smaller CLD correlates with a shallow anterior chamber and indicates a more crowded ciliary-lens configuration, a crucial indictor of PACG.
SN - 0146-0404
SN - 1552-5783
ER -