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Peer-reviewedCC BY 4.0Translational Vision Science & Technology

Factors Associated With Anterior Chamber Depth Changes in Primary Angle-Closure Suspects Over 5-Year Follow-Up

  • Fei Xiang1
  • Katherine Han2
  • Mengyang Li1
  • Gui-shuang Ying3
  • Xiaohua Pan4
  • Hui Feng1
  • Caixia Li5
  • Liqin Song6
  • Yi Wang1
  • Junying Ren1
  • Zehua Wang1
  • Zhi Li1
3 more authors
  • Na Jiang1
  • Ying Han7
  • Shuning Li1
7 affiliations
  1. 1Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Ophthalmology & Visual Sciences Key Laboratory, Capital Medical University, Beijing, China
  2. 2Albert Einstein College of Medicine, Bronx, NY, USA
  3. 3Center for Preventive Ophthalmology and Biostatistics, Department of Ophthalmology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
  4. 4Shenzhen Eye Hospital, Jinan University, Shenzhen Eye Institute, Shenzhen, China
  5. 5Shaanxi Eye Hospital, Xi'an People's Hospital (Xi'an Fourth Hospital), Xi'an, China
  6. 6Chen Zhou AIER Eye Hospital, Hunan, China
  7. 7Department of Ophthalmology, University of California, San Francisco, School of Medicine, San Francisco, CA, USA
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Abstract

Purpose: To evaluate longitudinal changes in anterior chamber depth (ACD) in primary angle-closure suspects (PACS) over 5-year follow-up and identify factors associated with these changes.

Methods: Participants aged 50 years or older were enrolled from Daxing District, Beijing, China. Anterior chamber parameters were assessed at baseline and at 5-year follow-up using anterior segment optical coherence tomography and Lenstar 900. Baseline demographics, ocular characteristics, and longitudinal changes in anterior chamber parameters were compared between groups. Univariate and multivariate linear regression analyses were performed to identify factors associated with changes in ACD.

Results: A total of 101 eyes with PACS and 136 control eyes without PACS (NPACS) were analyzed. At 5-year follow-up, both groups showed significant decreases in ACD and significant increases in lens thickness, lens thickness/axial length factor (LAF), and lens vault (LV) compared with baseline (all P < 0.001). In multivariate subgroup analyses stratified by baseline age (group A: 50–60 years, n = 128; group B: >60 years, n = 109), ACD shallowing in group A was associated with hypermetropia, greater follow-up to baseline change in LAF, and greater follow-up to baseline change in LV (all P < 0.001). In group B, ACD shallowing was associated with diagnosis of PACS (P = 0.027) and greater follow-up to baseline change in LV (P < 0.001).

Conclusions: ACD decreased over 5 years in participants with both PACS and NPACS. ACD shallowing was associated with both lens thickening and increased LV in relatively younger participants, whereas it was associated mainly with increased LV in relatively older participants.

Translational Relevance: These findings suggest that lens enlargement and anterior lens displacement may contribute differently to ACD shallowing across age groups, which may aid in the interpretation of longitudinal anterior segment changes in PACS.

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Cite

BibTeXRIS
BibTeX
@article{xiang2026factors,
  title = {{Factors Associated With Anterior Chamber Depth Changes in Primary Angle-Closure Suspects Over 5-Year Follow-Up}},
  author = {Fei Xiang and Katherine Han and Mengyang Li and Gui-shuang Ying and Xiaohua Pan and Hui Feng and Caixia Li and Liqin Song and Yi Wang and Junying Ren and Zehua Wang and Zhi Li and Na Jiang and Ying Han and Shuning Li},
  journal = {Translational Vision Science \& Technology},
  year = {2026},
  month = oct,
  doi = {10.1167/tvst.15.10.37},
  url = {https://doi.org/10.1167/tvst.15.10.37},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Factors Associated With Anterior Chamber Depth Changes in Primary Angle-Closure Suspects Over 5-Year Follow-Up
AU  - Fei Xiang
AU  - Katherine Han
AU  - Mengyang Li
AU  - Gui-shuang Ying
AU  - Xiaohua Pan
AU  - Hui Feng
AU  - Caixia Li
AU  - Liqin Song
AU  - Yi Wang
AU  - Junying Ren
AU  - Zehua Wang
AU  - Zhi Li
AU  - Na Jiang
AU  - Ying Han
AU  - Shuning Li
PY  - 2026
DA  - 2026/10/23
JO  - Translational Vision Science & Technology
DO  - 10.1167/tvst.15.10.37
UR  - https://doi.org/10.1167/tvst.15.10.37
AB  - Purpose: To evaluate longitudinal changes in anterior chamber depth (ACD) in primary angle-closure suspects (PACS) over 5-year follow-up and identify factors associated with these changes.  Methods: Participants aged 50 years or older were enrolled from Daxing District, Beijing, China. Anterior chamber parameters were assessed at baseline and at 5-year follow-up using anterior segment optical coherence tomography and Lenstar 900. Baseline demographics, ocular characteristics, and longitudinal changes in anterior chamber parameters were compared between groups. Univariate and multivariate linear regression analyses were performed to identify factors associated with changes in ACD.  Results: A total of 101 eyes with PACS and 136 control eyes without PACS (NPACS) were analyzed. At 5-year follow-up, both groups showed significant decreases in ACD and significant increases in lens thickness, lens thickness/axial length factor (LAF), and lens vault (LV) compared with baseline (all P < 0.001). In multivariate subgroup analyses stratified by baseline age (group A: 50–60 years, n = 128; group B: >60 years, n = 109), ACD shallowing in group A was associated with hypermetropia, greater follow-up to baseline change in LAF, and greater follow-up to baseline change in LV (all P < 0.001). In group B, ACD shallowing was associated with diagnosis of PACS (P = 0.027) and greater follow-up to baseline change in LV (P < 0.001).  Conclusions: ACD decreased over 5 years in participants with both PACS and NPACS. ACD shallowing was associated with both lens thickening and increased LV in relatively younger participants, whereas it was associated mainly with increased LV in relatively older participants.  Translational Relevance: These findings suggest that lens enlargement and anterior lens displacement may contribute differently to ACD shallowing across age groups, which may aid in the interpretation of longitudinal anterior segment changes in PACS.
SN  - 2164-2591
ER  -