Role of the triglyceride-glucose index in predicting parathyroidectomy in primary hyperparathyroidism.
- 1Department of Endocrinology and Metabolism, Gaziantep City Hospital, Gaziantep, Turkey. [email protected].
- 2Department of Endocrinology and Metabolism, Gaziantep City Hospital, Gaziantep, Turkey.
- 3Department of Endocrinology and Metabolism, Faculty of Medicine, Gaziantep Islam Science and Technology University, Gaziantep, Turkey.
Abstract
Objective
The triglyceride-glucose (TyG) index is an easily accessible novel indicator of insulin resistance. This study aimed to investigate the relationship between the TyG index and the homeostatic model assessment of insulin resistance (HOMA-IR) in patients with primary hyperparathyroidism (PHPT), compare these parameters with healthy controls, and evaluate whether the TyG index could serve as a potential new parameter in patients undergoing parathyroidectomy.Methods
We retrospectively analyzed PHPT patients diagnosed between October 2023 and May 2024 in a tertiary endocrinology clinic. TyG index and HOMA-IR were compared with age- and sex-matched healthy controls, and subgroup analyses were performed for parathyroidectomy status. Statistical tests included correlation analysis and ROC curves.Results
HOMA-IR, TyG index and HbA1c were higher in patients with hyperparathyroidism compared to the control group (p < 0.001). The area under the curve (AUC) of each curve was calculated. It was found that serum calcium (AUC: 0.910, 95% CI: 0.849-0.971), fasting serum insulin (AUC: 0.876, 95% CI: 0.799-0.953), HOMA (AUC: 0.877, 95% CI: 0.799-0.956) and TyG index (AUC: 0.859, 95% CI: 0.777-0.941) demonstrated a satisfactory diagnostic capacity, with serum calcium achieving the highest score. ROC analysis demonstrated high diagnostic performance of TyG index (AUC = 0.859, cut-off = 9.6, sensitivity 82.9%, specificity 73.0%) and HOMA-IR (AUC = 0.877, cut-off = 2.69, sensitivity 84.2%, specificity 76.3%).Conclusions
The TyG index (cut-off = 9.6) reliably identified PHPT patients requiring parathyroidectomy and may serve as a simple surrogate marker of insulin resistance.Clinical trial number
Not applicable.
Related
- The use of intraoperative parathyroid hormone assay in predicting the success and reduce morbidity of targeted minimal invasive parathyroidectomy for primary hyperparathyroidism
- Total parathyroidectomy versus total parathyroidectomy with autotransplantation for refractory secondary hyperparathyroidism: short-term biochemical outcomes and postoperative calcium supplementation burden
- Triglyceride-glucose index and risk of major adverse cardiovascular events in ST-segment elevation myocardial infarction patients undergoing primary percutaneous coronary intervention
- Prevalence of Triglyceride–Glucose Index-Defined Insulin Resistance and Its Association with Recorded Cardiovascular Disease Among Adults in the Municipality of Naples: A Cross-Sectional Primary-Care Study
- Delayed diagnosis leading to severe complications in primary hyperparathyroidism caused by atypical parathyroid tumor
BibTeX
@article{kocar2026role,
title = {{Role of the triglyceride-glucose index in predicting parathyroidectomy in primary hyperparathyroidism.}},
author = {İlkcan Çerçi Koçar and Neşe Bülbül},
journal = {BMC endocrine disorders},
year = {2026},
month = aug,
doi = {10.1186/s12902-026-02495-5},
url = {https://europepmc.org/article/MED/42907831},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Role of the triglyceride-glucose index in predicting parathyroidectomy in primary hyperparathyroidism.
AU - İlkcan Çerçi Koçar
AU - Neşe Bülbül
PY - 2026
DA - 2026/08/01
JO - BMC endocrine disorders
DO - 10.1186/s12902-026-02495-5
UR - https://europepmc.org/article/MED/42907831
AB - Objective The triglyceride-glucose (TyG) index is an easily accessible novel indicator of insulin resistance. This study aimed to investigate the relationship between the TyG index and the homeostatic model assessment of insulin resistance (HOMA-IR) in patients with primary hyperparathyroidism (PHPT), compare these parameters with healthy controls, and evaluate whether the TyG index could serve as a potential new parameter in patients undergoing parathyroidectomy.Methods We retrospectively analyzed PHPT patients diagnosed between October 2023 and May 2024 in a tertiary endocrinology clinic. TyG index and HOMA-IR were compared with age- and sex-matched healthy controls, and subgroup analyses were performed for parathyroidectomy status. Statistical tests included correlation analysis and ROC curves.Results HOMA-IR, TyG index and HbA1c were higher in patients with hyperparathyroidism compared to the control group (p < 0.001). The area under the curve (AUC) of each curve was calculated. It was found that serum calcium (AUC: 0.910, 95% CI: 0.849-0.971), fasting serum insulin (AUC: 0.876, 95% CI: 0.799-0.953), HOMA (AUC: 0.877, 95% CI: 0.799-0.956) and TyG index (AUC: 0.859, 95% CI: 0.777-0.941) demonstrated a satisfactory diagnostic capacity, with serum calcium achieving the highest score. ROC analysis demonstrated high diagnostic performance of TyG index (AUC = 0.859, cut-off = 9.6, sensitivity 82.9%, specificity 73.0%) and HOMA-IR (AUC = 0.877, cut-off = 2.69, sensitivity 84.2%, specificity 76.3%).Conclusions The TyG index (cut-off = 9.6) reliably identified PHPT patients requiring parathyroidectomy and may serve as a simple surrogate marker of insulin resistance.Clinical trial number Not applicable.
SN - 1472-6823
ER -