Triglyceride-glucose index and risk of major adverse cardiovascular events in ST-segment elevation myocardial infarction patients undergoing primary percutaneous coronary intervention
- 1Department of Cardiology, Medical Faculty, Eskisehir Osmangazi University, Eskişehir, Turkey
- 2Department of Cardiology, Eskisehir City Hospital, Eskişehir, Turkey
Abstract
Introduction: The triglyceride–glucose (TyG) index is a simple surrogate marker of insulin resistance that has been associated with adverse cardiovascular outcomes. However, its prognostic value in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI) remains incompletely defined.
Aim: To investigate the association between the TyG index and 1-year major adverse cardiovascular events (MACE) in STEMI patients.
Material and methods: This study included 757 consecutive STEMI patients who underwent primary PCI between 2019 and 2023. The TyG index was calculated using fasting triglyceride and glucose levels. Patients were stratified according to the median TyG value (9.24). The primary endpoint was MACE, defined as a composite of cardiovascular hospitalisation, stroke, non-fatal myocardial infarction, and all-cause mortality. Logistic regression and receiver operating characteristic (ROC) analyses were performed
Results: MACE occurred in 279 (36.8%) patients. Patients in the high-TyG group had a significantly higher incidence of MACE than those in the low-TyG group (41.8% vs. 31.9%, respectively, p = 0.003). In multivariable analysis, a high TyG index remained independently associated with MACE (OR = 1.548, 95% CI: 1.100–2.179, p = 0.012). ROC analysis demonstrated a statistically significant but modest discriminatory performance for MACE prediction (AUC = 0.573, 95% CI: 0.532–0.615, p = 0.001), with an optimal cut-off value of 9.38.
Conclusions: A higher TyG index was independently associated with an increased risk of 1-year MACE in STEMI patients undergoing primary PCI. Although its standalone discriminative performance was modest, the TyG index may provide complementary prognostic information and serve as a simple adjunctive tool for risk stratification.
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BibTeX
@article{murat2026triglycerideglucose,
title = {{Triglyceride-glucose index and risk of major adverse cardiovascular events in ST-segment elevation myocardial infarction patients undergoing primary percutaneous coronary intervention}},
author = {Selda Murat and Fatih Aydin and Bektas Murat},
journal = {Postepy w kardiologii interwencyjnej = Advances in interventional cardiology},
year = {2026},
month = sep,
doi = {10.5114/aic.2026.164546},
url = {https://europepmc.org/article/PMC/PMC13721078},
note = {CC BY-NC-SA},
}
RIS
TY - JOUR
TI - Triglyceride-glucose index and risk of major adverse cardiovascular events in ST-segment elevation myocardial infarction patients undergoing primary percutaneous coronary intervention
AU - Selda Murat
AU - Fatih Aydin
AU - Bektas Murat
PY - 2026
DA - 2026/09/01
JO - Postepy w kardiologii interwencyjnej = Advances in interventional cardiology
DO - 10.5114/aic.2026.164546
UR - https://europepmc.org/article/PMC/PMC13721078
AB - Introduction: The triglyceride–glucose (TyG) index is a simple surrogate marker of insulin resistance that has been associated with adverse cardiovascular outcomes. However, its prognostic value in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI) remains incompletely defined. Aim: To investigate the association between the TyG index and 1-year major adverse cardiovascular events (MACE) in STEMI patients. Material and methods: This study included 757 consecutive STEMI patients who underwent primary PCI between 2019 and 2023. The TyG index was calculated using fasting triglyceride and glucose levels. Patients were stratified according to the median TyG value (9.24). The primary endpoint was MACE, defined as a composite of cardiovascular hospitalisation, stroke, non-fatal myocardial infarction, and all-cause mortality. Logistic regression and receiver operating characteristic (ROC) analyses were performed Results: MACE occurred in 279 (36.8%) patients. Patients in the high-TyG group had a significantly higher incidence of MACE than those in the low-TyG group (41.8% vs. 31.9%, respectively, p = 0.003). In multivariable analysis, a high TyG index remained independently associated with MACE (OR = 1.548, 95% CI: 1.100–2.179, p = 0.012). ROC analysis demonstrated a statistically significant but modest discriminatory performance for MACE prediction (AUC = 0.573, 95% CI: 0.532–0.615, p = 0.001), with an optimal cut-off value of 9.38. Conclusions: A higher TyG index was independently associated with an increased risk of 1-year MACE in STEMI patients undergoing primary PCI. Although its standalone discriminative performance was modest, the TyG index may provide complementary prognostic information and serve as a simple adjunctive tool for risk stratification.
SN - 1734-9338
SN - 1897-4295
ER -