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Peer-reviewedLicence not statedScience

SGLT2 inhibitors activate pantothenate kinase in the human heart

  • Nicholas Forelli1,2
  • Trace Thome1,2
  • Deborah Eaton1,2
  • Kollin C. Schultz1,2
  • Jiten D. Patel1,2
  • Caitlyn E. Bowman1,2
  • Ryo Kawakami1,2
  • Jae Woo Jung1,2
  • Ivan A. Kuznetsov1,2
  • Kristina Li1,2
  • Jialiu A. Liang1,2
  • Kirsten Branch1,3
15 more authors
  • Claire Brady1,3
  • Kenneth C Bedi1,4
  • Yijun Yang1,4
  • Kaustubh Koya1,3
  • Nesrine Bouhrira1,5
  • Emily Megill6,2
  • Daniel S. Kantner6,2
  • Louis G. Smith7
  • Cristin F. MacIntosh7
  • Kushol Gupta7
  • Gregory R. Bowman7
  • Nathaniel W. Snyder6
  • Jonathan Edwards8
  • Kenneth B. Margulies1
  • Zoltan Pierre Arany1,9
9 affiliations
  1. 1Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
  2. 2Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
  3. 3Aging & Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA
  4. 4Departments of Biochemistry & Biophysics, and Bioengineering, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
  5. 5Division of Cardiology, Children's Hospital of Philadelphia, Philadelphia, PA
  6. 6Aging and Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA
  7. 7Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
  8. 8Division of Cardiology, Cardiovascular Institute, Children’s Hospital of Philadelphia, Philadelphia, PA, USA
  9. 9Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
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Cite

BibTeXRIS
BibTeX
@article{forelli2026sglt2,
  title = {{SGLT2 inhibitors activate pantothenate kinase in the human heart}},
  author = {Nicholas Forelli and Trace Thome and Deborah Eaton and Kollin C. Schultz and Jiten D. Patel and Caitlyn E. Bowman and Ryo Kawakami and Jae Woo Jung and Ivan A. Kuznetsov and Kristina Li and Jialiu A. Liang and Kirsten Branch and Claire Brady and Kenneth C Bedi and Yijun Yang and Kaustubh Koya and Nesrine Bouhrira and Emily Megill and Daniel S. Kantner and Louis G. Smith and Cristin F. MacIntosh and Kushol Gupta and Gregory R. Bowman and Nathaniel W. Snyder and Jonathan Edwards and Kenneth B. Margulies and Zoltan Pierre Arany},
  journal = {Science},
  year = {2026},
  month = aug,
  doi = {10.1126/science.aeh4856},
  url = {https://doi.org/10.1101/2024.07.26.605401},
}
RIS
TY  - JOUR
TI  - SGLT2 inhibitors activate pantothenate kinase in the human heart
AU  - Nicholas Forelli
AU  - Trace Thome
AU  - Deborah Eaton
AU  - Kollin C. Schultz
AU  - Jiten D. Patel
AU  - Caitlyn E. Bowman
AU  - Ryo Kawakami
AU  - Jae Woo Jung
AU  - Ivan A. Kuznetsov
AU  - Kristina Li
AU  - Jialiu A. Liang
AU  - Kirsten Branch
AU  - Claire Brady
AU  - Kenneth C Bedi
AU  - Yijun Yang
AU  - Kaustubh Koya
AU  - Nesrine Bouhrira
AU  - Emily Megill
AU  - Daniel S. Kantner
AU  - Louis G. Smith
AU  - Cristin F. MacIntosh
AU  - Kushol Gupta
AU  - Gregory R. Bowman
AU  - Nathaniel W. Snyder
AU  - Jonathan Edwards
AU  - Kenneth B. Margulies
AU  - Zoltan Pierre Arany
PY  - 2026
DA  - 2026/08/27
JO  - Science
DO  - 10.1126/science.aeh4856
UR  - https://doi.org/10.1101/2024.07.26.605401
SN  - 0036-8075
SN  - 0193-4511
SN  - 1095-9203
ER  -