The clinical applications of platelet-rich plasma and platelet-rich fibrin combined with photobiomodulation in regenerative dentistry: A literature review.
- 1Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
- 2Department of Orthodontics, School of Dentistry, Iran University of Medical Sciences, Tehran, Iran.
- 3Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Abstract
Regenerative dentistry seeks to restore oral tissues through biologically driven therapies that stimulate endogenous healing. Among these, autologous platelet concentrates-namely platelet-rich plasma (PRP) and platelet-rich fibrin (PRF)-serve as reservoirs of growth factors such as platelet-derived growth factor (PDGF), transforming growth factor-beta (TGF-β), vascular endothelial growth factor (VEGF), and insulin-like growth factor (IGF), which promote angiogenesis, cell proliferation, and extracellular matrix formation. Complementing these biological mediators, photobiomodulation (PBM) represents a non-invasive light-based therapy that enhances mitochondrial activity, modulates inflammation, and accelerates tissue regeneration. Accumulating evidence suggests that combining PRP or PRF with PBM produces synergistic effects that surpass those achieved by either modality alone. Experimental and clinical studies demonstrate enhanced angiogenesis, osteogenesis, and wound healing, supported by improved cellular metabolism, growth factor bioavailability, and fibrin architecture. The combined PRP/PRF-PBM approach has shown clinical efficacy across multiple regenerative contexts, including periodontal regeneration, dental implantology, socket preservation, regenerative endodontics, and the management of medication-related osteonecrosis of the jaw. Additionally, PRP and PRF exhibit antimicrobial effects against key oral pathogens, further reinforcing their therapeutic value. Despite promising results, outcome variability due to differences in preparation methods and PBM parameters highlights the need for standardization and rigorous clinical validation. As understanding deepens, integrating platelet concentrates with PBM may become a cornerstone of evidence-based regenerative dentistry, offering a comprehensive strategy that unites antimicrobial action with enhanced tissue repair.
Related
- Cold atmospheric plasma in skin repair, dermatology, regenerative medicine, and dentistry: A narrative review
- Photobiomodulation as a Potential Regenerative Signal in the Inner Ear: Linking Mitochondrial Redox Signaling to Cell-Fate Regulation.
- Regenerative Medicine in the Management of Musculoskeletal Pain: Mechanisms, Clinical Applications, and Future Directions.
- Artificial Intelligence in Contemporary Dentistry: Applications Across Dental Specialties and Future Challenges.
- Evaluating GPT-4o Model Proficiency and Clinical Reasoning for Antimicrobial Stewardship in Dentistry
BibTeX
@article{pourhajibagher2026clinical,
title = {{The clinical applications of platelet-rich plasma and platelet-rich fibrin combined with photobiomodulation in regenerative dentistry: A literature review.}},
author = {Maryam Pourhajibagher and Rashin Bahrami and Abbas Bahador},
journal = {Journal of dental sciences},
year = {2026},
month = oct,
doi = {10.1016/j.jds.2025.07.3569},
url = {https://europepmc.org/article/MED/42924205},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - The clinical applications of platelet-rich plasma and platelet-rich fibrin combined with photobiomodulation in regenerative dentistry: A literature review.
AU - Maryam Pourhajibagher
AU - Rashin Bahrami
AU - Abbas Bahador
PY - 2026
DA - 2026/10/01
JO - Journal of dental sciences
DO - 10.1016/j.jds.2025.07.3569
UR - https://europepmc.org/article/MED/42924205
AB - Regenerative dentistry seeks to restore oral tissues through biologically driven therapies that stimulate endogenous healing. Among these, autologous platelet concentrates-namely platelet-rich plasma (PRP) and platelet-rich fibrin (PRF)-serve as reservoirs of growth factors such as platelet-derived growth factor (PDGF), transforming growth factor-beta (TGF-β), vascular endothelial growth factor (VEGF), and insulin-like growth factor (IGF), which promote angiogenesis, cell proliferation, and extracellular matrix formation. Complementing these biological mediators, photobiomodulation (PBM) represents a non-invasive light-based therapy that enhances mitochondrial activity, modulates inflammation, and accelerates tissue regeneration. Accumulating evidence suggests that combining PRP or PRF with PBM produces synergistic effects that surpass those achieved by either modality alone. Experimental and clinical studies demonstrate enhanced angiogenesis, osteogenesis, and wound healing, supported by improved cellular metabolism, growth factor bioavailability, and fibrin architecture. The combined PRP/PRF-PBM approach has shown clinical efficacy across multiple regenerative contexts, including periodontal regeneration, dental implantology, socket preservation, regenerative endodontics, and the management of medication-related osteonecrosis of the jaw. Additionally, PRP and PRF exhibit antimicrobial effects against key oral pathogens, further reinforcing their therapeutic value. Despite promising results, outcome variability due to differences in preparation methods and PBM parameters highlights the need for standardization and rigorous clinical validation. As understanding deepens, integrating platelet concentrates with PBM may become a cornerstone of evidence-based regenerative dentistry, offering a comprehensive strategy that unites antimicrobial action with enhanced tissue repair.
SN - 1991-7902
SN - 2213-8862
ER -