Incidence, prevalence, mortality and survival trends in women with endometrial-, ovarian- and cervical cancer in the Nordic countries (1980–2023) with focus on younger women (0–49 years old)
Abstract
OBJECTIVE: Endometrial, ovarian, and cervical cancers predominantly affect middle-aged and older women, but temporal trends may differ in younger women due to distinct risk factors and clinical characteristics. We therefore assessed temporal trends in incidence, prevalence, mortality, and survival across these cancers in younger women. METHODS: Using population-based NORDCAN registry data, we identified women aged 0-49 years diagnosed with endometrial, ovarian, or cervical cancer in the Nordic countries between 1980 and 2023. Incidence, prevalence, mortality, and five-year relative survival (RS) were age-standardized, with the latter estimated using the Pohar-Perme method. RESULTS: Endometrial cancer incidence rates increased from 1.4 to 1.9 cases per 100,000 person-years (PY) between 1998 and 2000 and 2021-2023 (36% increase). Over the full study period, incidence rates declined for both ovarian cancer (4.2 to 2.1 cases per 100,000 PY; 50% decrease) and cervical cancer (6.5 to 5.5 cases per 100,000 PY; 15% decrease). Mortality rates decreased for women with ovarian cancer (1.9 to 0.6 per 100,000 PY; 75% decrease) and cervical cancer (1.5 to 0.5 per 100 00 PY; 67% decrease), while remaining steady at ≤ 0.2 per 100,000 PY for endometrial cancer. RS estimates remained high for endometrial cancer (90-95%). Cervical cancer five-year RS improved from 77-83% in 1979-1983 to 89-93% in 2019-2023, while ovarian cancer increased from 48-64% to 68-81%. CONCLUSIONS: Gynecological cancers show distinct temporal trends among young women in the Nordic countries. These findings underscore the importance of age-specific prevention strategies, including obesity prevention, monitoring contraceptive trends, and continued implementation of HPV-based screening and vaccination.
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BibTeX
@article{riese2026incidence,
title = {{Incidence, prevalence, mortality and survival trends in women with endometrial-, ovarian- and cervical cancer in the Nordic countries (1980–2023) with focus on younger women (0–49 years old)}},
author = {Charlotta Riese and Enoch Yi-Tung and Hanna Nilsson and Sahar Salehi and Anna Sara Oberg and Simon Mathis Kønig and Richard Feltbower and Christine Rousset-Jablonski and Magdalena Balcerek and Kenny Rodriguez-Wallberg and Enoch Yi-Tung Chen},
journal = {Gynecologic Oncology},
year = {2026},
month = sep,
doi = {10.1016/j.ygyno.2026.08.014},
url = {https://hal.science/hal-05749354v1},
note = {CC BY},
}
RIS
TY - JOUR
TI - Incidence, prevalence, mortality and survival trends in women with endometrial-, ovarian- and cervical cancer in the Nordic countries (1980–2023) with focus on younger women (0–49 years old)
AU - Charlotta Riese
AU - Enoch Yi-Tung
AU - Hanna Nilsson
AU - Sahar Salehi
AU - Anna Sara Oberg
AU - Simon Mathis Kønig
AU - Richard Feltbower
AU - Christine Rousset-Jablonski
AU - Magdalena Balcerek
AU - Kenny Rodriguez-Wallberg
AU - Enoch Yi-Tung Chen
PY - 2026
DA - 2026/09/14
JO - Gynecologic Oncology
DO - 10.1016/j.ygyno.2026.08.014
UR - https://hal.science/hal-05749354v1
AB - OBJECTIVE: Endometrial, ovarian, and cervical cancers predominantly affect middle-aged and older women, but temporal trends may differ in younger women due to distinct risk factors and clinical characteristics. We therefore assessed temporal trends in incidence, prevalence, mortality, and survival across these cancers in younger women. METHODS: Using population-based NORDCAN registry data, we identified women aged 0-49 years diagnosed with endometrial, ovarian, or cervical cancer in the Nordic countries between 1980 and 2023. Incidence, prevalence, mortality, and five-year relative survival (RS) were age-standardized, with the latter estimated using the Pohar-Perme method. RESULTS: Endometrial cancer incidence rates increased from 1.4 to 1.9 cases per 100,000 person-years (PY) between 1998 and 2000 and 2021-2023 (36% increase). Over the full study period, incidence rates declined for both ovarian cancer (4.2 to 2.1 cases per 100,000 PY; 50% decrease) and cervical cancer (6.5 to 5.5 cases per 100,000 PY; 15% decrease). Mortality rates decreased for women with ovarian cancer (1.9 to 0.6 per 100,000 PY; 75% decrease) and cervical cancer (1.5 to 0.5 per 100 00 PY; 67% decrease), while remaining steady at ≤ 0.2 per 100,000 PY for endometrial cancer. RS estimates remained high for endometrial cancer (90-95%). Cervical cancer five-year RS improved from 77-83% in 1979-1983 to 89-93% in 2019-2023, while ovarian cancer increased from 48-64% to 68-81%. CONCLUSIONS: Gynecological cancers show distinct temporal trends among young women in the Nordic countries. These findings underscore the importance of age-specific prevention strategies, including obesity prevention, monitoring contraceptive trends, and continued implementation of HPV-based screening and vaccination.
SN - 0090-8258
SN - 1095-6859
ER -