Impact of unilateral salpingectomy on ovarian reserve and long-term reproductive outcomes in reproductive-aged women
- 1Department of Obstetrics and Gynecology, Jinshan Branch of Shanghai Sixth People’s Hospital, Shanghai, China
Abstract
Objective: To investigate the short-term impact of unilateral salpingectomy on ovarian reserve and to evaluate its comprehensive value regarding long-term reproductive outcomes in women of reproductive age.
Methods: In this prospective cohort study, 96 reproductive-aged women diagnosed with ectopic pregnancy (EP) were enrolled. Base on the surgical and therapeutic regimens, participants were allocated into a study group (undergoing laparoscopic unilateral salpingectomy, n = 48) and a control group (preservation of the fallopian tube, including either laparoscopic salpingostomy or systemic methotrexate [MTX] therapy, n = 48). Biochemical markers of ovarian reserve (anti-Müllerian hormone [AMH], serum follicle-stimulating hormone [FSH], etc.) and morphological parameters (ovarian volume and antral follicle count [AFC]) were dynamically monitored and compared between the two groups at baseline and at 1, 3, and 6 months postoperatively. All participants were followed up for 24 months to compare spontaneous ovulation rates, spontaneous pregnancy rates, and the incidence of recurrent EP.
Results: The study group exhibited transient fluctuations in biochemical markers indicative of diminished ovarian reserve in the early postoperative period (1 month), which normalized by 6 months postoperatively. Regarding morphological compensation, the contralateral ovarian volume and AFC in the study group increased significantly at 1–3 months postoperatively compared with the control group (P< 0.05); however, these parameters converged between the two groups by 6 months (P>0.05). Over the 24-month follow-up, there were no statistically significant differences in spontaneous ovulation or spontaneous pregnancy rates between the groups (P>0.05). Notably, the recurrence rate of EP in the study group was 2.08% (1/48), significantly lower than the 16.67% (8/48) observed in the control group (P< 0.05).
Conclusions: Unilateral salpingectomy induces a transient early decline in ovarian reserve, counterbalanced by a distinct short-term compensatory response in the contralateral ovary. Crucially, this procedure does not compromise long-term natural conception potential while significantly mitigating the risk of recurrent EP. For patients with normal ovarian reserve and a healthy contralateral tube, unilateral salpingectomy represents a safe, effective, and optimal treatment strategy for maximizing protection against recurrent EP.
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BibTeX
@article{zhou2026impact,
title = {{Impact of unilateral salpingectomy on ovarian reserve and long-term reproductive outcomes in reproductive-aged women}},
author = {Yanna Zhou and Yiting Yang},
journal = {Frontiers in Endocrinology},
year = {2026},
month = oct,
doi = {10.3389/fendo.2026.1952475},
url = {https://doi.org/10.3389/fendo.2026.1952475},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Impact of unilateral salpingectomy on ovarian reserve and long-term reproductive outcomes in reproductive-aged women
AU - Yanna Zhou
AU - Yiting Yang
PY - 2026
DA - 2026/10/12
JO - Frontiers in Endocrinology
DO - 10.3389/fendo.2026.1952475
UR - https://doi.org/10.3389/fendo.2026.1952475
AB - Objective: To investigate the short-term impact of unilateral salpingectomy on ovarian reserve and to evaluate its comprehensive value regarding long-term reproductive outcomes in women of reproductive age. Methods: In this prospective cohort study, 96 reproductive-aged women diagnosed with ectopic pregnancy (EP) were enrolled. Base on the surgical and therapeutic regimens, participants were allocated into a study group (undergoing laparoscopic unilateral salpingectomy, n = 48) and a control group (preservation of the fallopian tube, including either laparoscopic salpingostomy or systemic methotrexate [MTX] therapy, n = 48). Biochemical markers of ovarian reserve (anti-Müllerian hormone [AMH], serum follicle-stimulating hormone [FSH], etc.) and morphological parameters (ovarian volume and antral follicle count [AFC]) were dynamically monitored and compared between the two groups at baseline and at 1, 3, and 6 months postoperatively. All participants were followed up for 24 months to compare spontaneous ovulation rates, spontaneous pregnancy rates, and the incidence of recurrent EP. Results: The study group exhibited transient fluctuations in biochemical markers indicative of diminished ovarian reserve in the early postoperative period (1 month), which normalized by 6 months postoperatively. Regarding morphological compensation, the contralateral ovarian volume and AFC in the study group increased significantly at 1–3 months postoperatively compared with the control group (P< 0.05); however, these parameters converged between the two groups by 6 months (P>0.05). Over the 24-month follow-up, there were no statistically significant differences in spontaneous ovulation or spontaneous pregnancy rates between the groups (P>0.05). Notably, the recurrence rate of EP in the study group was 2.08% (1/48), significantly lower than the 16.67% (8/48) observed in the control group (P< 0.05). Conclusions: Unilateral salpingectomy induces a transient early decline in ovarian reserve, counterbalanced by a distinct short-term compensatory response in the contralateral ovary. Crucially, this procedure does not compromise long-term natural conception potential while significantly mitigating the risk of recurrent EP. For patients with normal ovarian reserve and a healthy contralateral tube, unilateral salpingectomy represents a safe, effective, and optimal treatment strategy for maximizing protection against recurrent EP.
SN - 1664-2392
ER -