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Peer-reviewedCC BY 4.0Journal of Human Immunity

The rise in prevalence of autoantibodies neutralizing type I interferons reaches a plateau in centenarians

  • Nanna Mørk1,2
  • Julie A. Jensen1,2
  • Paul Bastard3,4,5
  • Lisbeth Aagaard Larsen6
  • Bettina Bundgaard1,2
  • Marianne Nygaard6
  • Signe Bedsted Clemmensen6
  • Chiaki Tao7
  • Vibeke Sorensen Catts8
  • Anne Puel3,4,9
  • Guillaume Vogt3,4
  • Ivan David Lozada-Martinez10,11
8 more authors
  • Juan-Manuel Anaya10,11
  • Yasumichi Arai12,13
  • Perminder Singh Sachdev8
  • Satoshi Okada7
  • Jean-Laurent Casanova3,4,14,15,16
  • Kaare Christensen6
  • Aurélie Cobat3,4,14,15
  • Trine H. Mogensen1,2,17
17 affiliations
  1. 1Department of Biomedicine, Aarhus University, Aarhus, Denmark
  2. 2Center for Immunology of Viral Infections, Aarhus University, Aarhus, Denmark
  3. 3Laboratory of Human Genetics of Infectious Diseases, Institut Imagine, Université Paris Cité, Necker Branch, INSERM UMR 1163, Paris, France
  4. 4Paris City University, Imagine Institute, Paris, France
  5. 5Pediatric Hematology-Immunology & Rheumatology Unit, Necker Hospital for Children, Assistance Publique-Hôpitaux de Paris, Paris, France
  6. 6Department of Public Health, Danish Aging Research Center, University of Southern Denmark, Odense, Denmark
  7. 7Department of Pediatrics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan
  8. 8Discipline of Psychiatry & Mental Health School of Clinical Medicine, Faculty of Medicine and Health, Centre for Healthy Brain Ageing, UNSW Sydney, Sydney, Australia
  9. 9Department of Pediatrics, Necker Hospital for Sick Children, Assistance Publique-Hôpitaux de Paris, Paris, France
  10. 10Center for Healthy Longevity, Universidad de la Costa, Barranquilla, Colombia
  11. 11Colombian Centenarian Alliance, Bogotá, Colombia
  12. 12Center for Supercentenarian Medical Research, Keio University School of Medicine, Tokyo, Japan
  13. 13Human Biology Microbiome Quantum Research Center (Bio2Q), Keio University, Tokyo, Japan
  14. 14Laboratory of Human Genetics of Infectious Diseases, Center for the Genetics of Host Defense, University of Texas Southwestern, Dallas, TX, USA
  15. 15Departments of Pediatrics and Immunology, and Children Research Institute, University of Texas Southwestern, Dallas, TX, USA
  16. 16Howard Hughes Medical Institute, New York, NY, USA
  17. 17Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark
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Abstract

While autoantibodies (auto-Abs) neutralizing type I interferons (IFN-I) are relatively rare before the age of 65 (<1%), their prevalence reaches 2–3% between 70 and 80 years and >6% in individuals above 80 years in the general population. To assess the prevalence of IFN-I auto-Abs at the extreme end of human lifespan, we performed a multinational study of centenarians from four geographically and ethnically distinct cohorts collected in Denmark (n = 258), Colombia (n = 99), Australia (n = 281), and Japan (n = 300), comprising 938 individuals. Across cohorts, 51/938 centenarians (5.4%) harbored auto-Abs neutralizing IFN-I, ranging from 3.3% (Japan) to 9.1% (Colombia). We found that the prevalence of IFN-I auto-Abs levels off in centenarians compared with individuals ≥80 years from the general population, demonstrating that neutralizing IFN-I auto-Abs are not incompatible with longevity, despite conferring a risk of life-threatening viral infections. Yet, the plateau of their prevalence in centenarians suggests that they may not be beneficial for reaching exceptional longevity and may negatively impact mortality.

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Cite

BibTeXRIS
BibTeX
@article{mork2026rise,
  title = {{The rise in prevalence of autoantibodies neutralizing type I interferons reaches a plateau in centenarians}},
  author = {Nanna Mørk and Julie A. Jensen and Paul Bastard and Lisbeth Aagaard Larsen and Bettina Bundgaard and Marianne Nygaard and Signe Bedsted Clemmensen and Chiaki Tao and Vibeke Sorensen Catts and Anne Puel and Guillaume Vogt and Ivan David Lozada-Martinez and Juan-Manuel Anaya and Yasumichi Arai and Perminder Singh Sachdev and Satoshi Okada and Jean-Laurent Casanova and Kaare Christensen and Aurélie Cobat and Trine H. Mogensen},
  journal = {Journal of Human Immunity},
  year = {2026},
  month = oct,
  doi = {10.70962/jhi.20260143},
  url = {https://doi.org/10.70962/jhi.20260143},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - The rise in prevalence of autoantibodies neutralizing type I interferons reaches a plateau in centenarians
AU  - Nanna Mørk
AU  - Julie A. Jensen
AU  - Paul Bastard
AU  - Lisbeth Aagaard Larsen
AU  - Bettina Bundgaard
AU  - Marianne Nygaard
AU  - Signe Bedsted Clemmensen
AU  - Chiaki Tao
AU  - Vibeke Sorensen Catts
AU  - Anne Puel
AU  - Guillaume Vogt
AU  - Ivan David Lozada-Martinez
AU  - Juan-Manuel Anaya
AU  - Yasumichi Arai
AU  - Perminder Singh Sachdev
AU  - Satoshi Okada
AU  - Jean-Laurent Casanova
AU  - Kaare Christensen
AU  - Aurélie Cobat
AU  - Trine H. Mogensen
PY  - 2026
DA  - 2026/10/27
JO  - Journal of Human Immunity
DO  - 10.70962/jhi.20260143
UR  - https://doi.org/10.70962/jhi.20260143
AB  - While autoantibodies (auto-Abs) neutralizing type I interferons (IFN-I) are relatively rare before the age of 65 (<1%), their prevalence reaches 2–3% between 70 and 80 years and >6% in individuals above 80 years in the general population. To assess the prevalence of IFN-I auto-Abs at the extreme end of human lifespan, we performed a multinational study of centenarians from four geographically and ethnically distinct cohorts collected in Denmark (n = 258), Colombia (n = 99), Australia (n = 281), and Japan (n = 300), comprising 938 individuals. Across cohorts, 51/938 centenarians (5.4%) harbored auto-Abs neutralizing IFN-I, ranging from 3.3% (Japan) to 9.1% (Colombia). We found that the prevalence of IFN-I auto-Abs levels off in centenarians compared with individuals ≥80 years from the general population, demonstrating that neutralizing IFN-I auto-Abs are not incompatible with longevity, despite conferring a risk of life-threatening viral infections. Yet, the plateau of their prevalence in centenarians suggests that they may not be beneficial for reaching exceptional longevity and may negatively impact mortality.
SN  - 3065-8993
ER  -