Skip to content
DraconiticResearch
Search Sources API
203,234 studies31 sourcesUpdated 3 min ago
Peer-reviewedCC BYJournal of human immunity

Autoantibodies neutralizing type I interferons in older twin pairs: Low concordance.

  • Signe Bedsted Clemmensen1,2
  • Nanna Mørk3,4
  • Julie A Jensen3,4
  • Lisbeth Aagaard Larsen1,2
  • Bettina Bundgaard3
  • Marianne Nygaard1,2
  • Michelle Møhlenberg3,4
  • Morten K Skouboe3
  • Adrian Gervais5,6
  • Paul Bastard5,6,7
  • Anne Puel5,6
  • Aurelie Cobat5,6
3 more authors
  • Jean-Laurent Casanova5,6,8,9,10
  • Kaare Christensen1,2
  • Trine H Mogensen3,4
10 affiliations
  1. 1Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Odense, Denmark.
  2. 2The Danish Twin Registry, Department of Public Health, University of Southern Denmark, Odense, Denmark.
  3. 3Department of Biomedicine, Aarhus University, Aarhus, Denmark.
  4. 4Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.
  5. 5Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale U1163, Necker Hospital for Sick Children, Paris, France.
  6. 6Imagine Institute, Paris Cité University , Paris, France.
  7. 7Pediatric Hematology-Immunology and Rheumatology Unit, Necker Hospital for Sick Children, Assistance Publique-Hôpitaux de Paris, Paris, France.
  8. 8Laboratory of Human Genetics of Infectious Diseases, Center for the Genetics of Host Defense, University of Texas Southwestern, Dallas, TX, USA.
  9. 9Departments of Pediatrics and Immunology, and Children Research Institute, University of Texas Southwestern, Dallas, TX, USA.
  10. 10Howard Hughes Medical Institute , New York, NY, USA.
Read full textPDFDOICite

Abstract

Autoantibodies (auto-Abs) neutralizing type I interferons (IFN-I) underlie various life-threatening viral infections, and the prevalence of these auto-Abs rises sharply between 65 and 70 years of age. We investigated the familial aggregation of neutralizing IFN-I auto-Abs by assessing concordance rates in Danish older twins, including 3,270 twins aged 65-96 years in a sample comprising 1,318 intact twin pairs (2,636 individuals) and 634 twins from broken twin pairs (634 individuals). Neutralizing IFN-I auto-Abs were detected in 1.5% (50/3,270) of all twins tested, including 1.4% (37/2,636) in twins from intact pairs and 2.1% (13/634) in twins from broken pairs. A total of 50 twins had neutralizing IFN-I auto-Abs, including one concordant monozygotic pair and 35 discordant pairs, yielding a low overall concordance rate. A slight, but nonsignificant, increase in mortality was associated with harboring neutralizing IFN-I auto-Abs. Collectively, these findings do not reveal any familial aggregation of IFN-I auto-Abs, arguing against a strong germline genetic etiology of IFN-I auto-Abs in older adults.

Related

  1. The rise in prevalence of autoantibodies neutralizing type I interferons reaches a plateau in centenarians
    Nanna Mørk, Julie A. Jensen, Paul Bastard +17
    Journal of Human ImmunityPeer-reviewedCC BY 4.0Full textImmunologyPMC
  2. Highly neutralizing anti–IFN-ω autoantibodies underlie severe pediatric adenovirus infection
    Chen-Xuan Kang, Jing-Ya Ding, Yu-Fang Lo +15
    Journal of human immunityPeer-reviewedCC BYFull textImmunologyEurope PMC
  3. Effect of exogenous interferons on rhinovirus replication and airway inflammatory responses
    T. M. Becker, S. R. Durrani, Y. A. Bochkov +3
    Annals of Allergy, Asthma and ImmunologyPeer-reviewedLicence not stated30 citedMicrobiologyHAL
  4. Investigating the association between interferons and flares of systemic lupus erythematosus at a single cell level
    Zoha Faheem, Giselle M. Boukhaled, Carol Nassar +9
    Frontiers in ImmunologyPeer-reviewedCC BY 4.0Full textImmunologyCrossrefEurope PMC
  5. Differential Effects of Distinct Type I Interferons and IFN Inducers on Fc Receptor landscape and myeloid cell function
    Rémi Bru, Océane Paris, Guillaume Bossis +3
    HALPreprintCC BY-NC-ND 4.0Full textProteomics & metabolomicsImmunologyHALbioRxiv

Cite

BibTeXRIS
BibTeX
@article{clemmensen2026autoantibodies,
  title = {{Autoantibodies neutralizing type I interferons in older twin pairs: Low concordance.}},
  author = {Signe Bedsted Clemmensen and Nanna Mørk and Julie A Jensen and Lisbeth Aagaard Larsen and Bettina Bundgaard and Marianne Nygaard and Michelle Møhlenberg and Morten K Skouboe and Adrian Gervais and Paul Bastard and Anne Puel and Aurelie Cobat and Jean-Laurent Casanova and Kaare Christensen and Trine H Mogensen},
  journal = {Journal of human immunity},
  year = {2026},
  month = oct,
  doi = {10.70962/jhi.20260142},
  url = {https://europepmc.org/article/MED/42853147},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Autoantibodies neutralizing type I interferons in older twin pairs: Low concordance.
AU  - Signe Bedsted Clemmensen
AU  - Nanna Mørk
AU  - Julie A Jensen
AU  - Lisbeth Aagaard Larsen
AU  - Bettina Bundgaard
AU  - Marianne Nygaard
AU  - Michelle Møhlenberg
AU  - Morten K Skouboe
AU  - Adrian Gervais
AU  - Paul Bastard
AU  - Anne Puel
AU  - Aurelie Cobat
AU  - Jean-Laurent Casanova
AU  - Kaare Christensen
AU  - Trine H Mogensen
PY  - 2026
DA  - 2026/10/09
JO  - Journal of human immunity
DO  - 10.70962/jhi.20260142
UR  - https://europepmc.org/article/MED/42853147
AB  - Autoantibodies (auto-Abs) neutralizing type I interferons (IFN-I) underlie various life-threatening viral infections, and the prevalence of these auto-Abs rises sharply between 65 and 70 years of age. We investigated the familial aggregation of neutralizing IFN-I auto-Abs by assessing concordance rates in Danish older twins, including 3,270 twins aged 65-96 years in a sample comprising 1,318 intact twin pairs (2,636 individuals) and 634 twins from broken twin pairs (634 individuals). Neutralizing IFN-I auto-Abs were detected in 1.5% (50/3,270) of all twins tested, including 1.4% (37/2,636) in twins from intact pairs and 2.1% (13/634) in twins from broken pairs. A total of 50 twins had neutralizing IFN-I auto-Abs, including one concordant monozygotic pair and 35 discordant pairs, yielding a low overall concordance rate. A slight, but nonsignificant, increase in mortality was associated with harboring neutralizing IFN-I auto-Abs. Collectively, these findings do not reveal any familial aggregation of IFN-I auto-Abs, arguing against a strong germline genetic etiology of IFN-I auto-Abs in older adults.
SN  - 3065-8993
ER  -