Skip to content
DraconiticResearch
Search Sources API
203,203 studies31 sourcesUpdated 34 min ago
Peer-reviewedCC BY-NC-NDMolecular medicine reports

Research progress in synergistic multimechanism of nanomaterial-mediated neuroinflammatory therapy (Review).

  • Heng Wang1
  • Pei Yang1
  • Wantao Liu1
  1. 1Department of Human Anatomy, Gansu Medical College, Pinliang, Gansu 744000, P.R. China.
Read full textPDFDOICite

Abstract

Neuroinflammation treatment faces notable challenges such as low blood‑brain barrier (BBB) penetration, poor targeting and systemic toxicity, limiting traditional therapies due to inefficient drug delivery and bioavailability. Nanomaterials have innovatively reshaped this paradigm through multiple mechanisms. The present review elaborates core strategies in immunocyte phenotype regulation, oxidative stress intervention and targeted delivery, focusing on modulating microglia transition from pro‑inflammatory to repair states, constructing systems for reactive oxygen species regulation and developing biomimetic carriers for BBB penetration and lesion targeting. The present review highlights technical bottlenecks in long‑term biosafety evaluation, cross‑organ metabolic mechanism analysis and clinical translation standardization.

Related

  1. Clinical research progress in hepatic cirrhosis
    Yifan Han, Yun Dai, Xiaoyuan Xu
    Journal of translational internal medicinePeer-reviewedCC BYFull textGeneral medicineEurope PMCEurope PMCPMC
  2. Research Progress on Genotoxicity and Molecular Mechanisms of Environmental Endocrine Disruptors
    Junmei Xia, Jiaying Li, Yingxin Yang +3
    ToxicsPeer-reviewedCC BYFull textPharmacology & toxicologyEurope PMC
  3. Research progress and practical applications of musculoskeletal ultrasound in military training injuries
    Shuo Wang, Hanhan Xu, Qianqian Liu +2
    Frontiers in medicinePeer-reviewedCC BYFull textGeneral medicineEurope PMC
  4. Clinical recognition, management, and research progress of infantile perianal protrusion: a narrative review and literature-based case aggregation
    Lintao Liu, Liyun Xia, Shuangai Liu +1
    Frontiers in pediatricsPeer-reviewedCC BYFull textGeneral medicineEurope PMC
  5. Gender Disparity in Movement Disorders Research Authorship: Progress and Persistent Gaps Across a Decade
    Divyani Garg, Zakiyah Aldaajani, Manon Auffret +11
    Movement DisordersPeer-reviewedLicence not statedFull textNeurologyHAL

Cite

BibTeXRIS
BibTeX
@article{wang2026research,
  title = {{Research progress in synergistic multimechanism of nanomaterial-mediated neuroinflammatory therapy (Review).}},
  author = {Heng Wang and Pei Yang and Wantao Liu},
  journal = {Molecular medicine reports},
  year = {2026},
  month = oct,
  doi = {10.3892/mmr.2026.14037},
  url = {https://europepmc.org/article/MED/42852620},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Research progress in synergistic multimechanism of nanomaterial-mediated neuroinflammatory therapy (Review).
AU  - Heng Wang
AU  - Pei Yang
AU  - Wantao Liu
PY  - 2026
DA  - 2026/10/09
JO  - Molecular medicine reports
DO  - 10.3892/mmr.2026.14037
UR  - https://europepmc.org/article/MED/42852620
AB  - Neuroinflammation treatment faces notable challenges such as low blood‑brain barrier (BBB) penetration, poor targeting and systemic toxicity, limiting traditional therapies due to inefficient drug delivery and bioavailability. Nanomaterials have innovatively reshaped this paradigm through multiple mechanisms. The present review elaborates core strategies in immunocyte phenotype regulation, oxidative stress intervention and targeted delivery, focusing on modulating microglia transition from pro‑inflammatory to repair states, constructing systems for reactive oxygen species regulation and developing biomimetic carriers for BBB penetration and lesion targeting. The present review highlights technical bottlenecks in long‑term biosafety evaluation, cross‑organ metabolic mechanism analysis and clinical translation standardization.
SN  - 1791-2997
SN  - 1791-3004
ER  -