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Peer-reviewedCC BYJournal of the Royal Society, Interface

Mathematical simulations of paediatric haemodynamics in isolated ventricular septal defect.

  • Mitchel J Colebank1,2
  • Alfonso Limon3
  • Anthony Chang3
  • Brandon Wong3,4
  • Wyman Lai3,4
  • Hamilton Baker5
5 affiliations
  1. 1Department of Mathematics, University of South Carolina , Columbia, SC, USA.
  2. 2Department of Biomedical Engineering, University of South Carolina , Columbia, SC, USA.
  3. 3Rady Children's Health of Orange County , Orange, CA, USA.
  4. 4University of California Irvine , Irvine, CA, USA.
  5. 5Medical University of South Carolina , Charleston, SC, USA.
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Abstract

Computer modelling of the cardiovascular system has the potential to revolutionize personalized medical care. This is especially promising for congenital heart defects, such as ventricular septal defect (VSD), a hole between the two ventricles of the heart. However, relatively few studies have built computer models for VSD, nor have they considered how natural adaptation to the cardiovascular system with age might interact with the presence of a small-, medium- or large-sized VSD. Here, we combine a lumped-parameter model of the cardiovascular system with two key modelling components: a size-dependent resistance dictating shunt flow between the two ventricles and age-dependent scaling relationships for the systemic and pulmonary circulations. Our results provide insight into changes in haemodynamic conditions with various VSD sizes. We investigate the combined effects of VSD size, vascular parameters and age, showing distinct differences with these three factors. This study lays the necessary foundation for studying VSD and towards building digital shadows and digital twins for managing VSD in paediatrics.

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Cite

BibTeXRIS
BibTeX
@article{colebank2026mathematical,
  title = {{Mathematical simulations of paediatric haemodynamics in isolated ventricular septal defect.}},
  author = {Mitchel J Colebank and Alfonso Limon and Anthony Chang and Brandon Wong and Wyman Lai and Hamilton Baker},
  journal = {Journal of the Royal Society, Interface},
  year = {2026},
  month = oct,
  doi = {10.1098/rsif.2026.0187},
  url = {https://europepmc.org/article/MED/42869463},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Mathematical simulations of paediatric haemodynamics in isolated ventricular septal defect.
AU  - Mitchel J Colebank
AU  - Alfonso Limon
AU  - Anthony Chang
AU  - Brandon Wong
AU  - Wyman Lai
AU  - Hamilton Baker
PY  - 2026
DA  - 2026/10/01
JO  - Journal of the Royal Society, Interface
DO  - 10.1098/rsif.2026.0187
UR  - https://europepmc.org/article/MED/42869463
AB  - Computer modelling of the cardiovascular system has the potential to revolutionize personalized medical care. This is especially promising for congenital heart defects, such as ventricular septal defect (VSD), a hole between the two ventricles of the heart. However, relatively few studies have built computer models for VSD, nor have they considered how natural adaptation to the cardiovascular system with age might interact with the presence of a small-, medium- or large-sized VSD. Here, we combine a lumped-parameter model of the cardiovascular system with two key modelling components: a size-dependent resistance dictating shunt flow between the two ventricles and age-dependent scaling relationships for the systemic and pulmonary circulations. Our results provide insight into changes in haemodynamic conditions with various VSD sizes. We investigate the combined effects of VSD size, vascular parameters and age, showing distinct differences with these three factors. This study lays the necessary foundation for studying VSD and towards building digital shadows and digital twins for managing VSD in paediatrics.
SN  - 1742-5689
SN  - 1742-5662
ER  -