DES-Based Green Synthesis of 2D Fluorescent Molybdenum Disulfide for Highly Sensitive and Selective Detection of Nifedipine.
6 affiliations
- 1Department of Chemistry, National Sun Yat-Sen University, Kaohsiung, 70, Lien-Hai Road, Kaohsiung80424, Taiwan.
- 2School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung807, Taiwan.
- 3School of Medicine, College of Medicine, National Sun Yat-Sen University, Kaohsiung80424, Taiwan.
- 4Institute of Medical Science and Technology, National Sun Yat-Sen University, Kaohsiung80424, Taiwan.
- 5Institute of Precision Medicine, National Sun Yat-Sen University, Kaohsiung80424, Taiwan.
- 6Institute of Bio Pharmaceutical Science, National Sun Yat-Sen University, Kaohsiung80424, Taiwan.
Abstract
Highly fluorescent 2D MoS2-x nanosheets exhibiting intense blue emission were synthesized using a green chemistry approach, utilizing DES as both the reaction medium and a surface passivating agent. The material was synthesized via a hydrothermal method, followed by ultrasonication-assisted exfoliation to yield ultrathin nanosheets with enhanced photoluminescence properties. The 2D MoS2-x nanosheets demonstrated strong fluorescence at λem = 420 nm when excited at λex = 330 nm. These nanosheets were employed as a fluorescence probe for the detection of the calcium channel blocker drug nifedipine (NIF) via a fluorescence quenching mechanism. Upon addition of NIF, the fluorescence of the 2D MoS2-x nanosheets was quenched due to electron transfer from the nanosheets to the electron-deficient NIF molecules, combined with the inner filter effect (IFE). The nanosheets enabled highly sensitive and selective detection of NIF, with photoluminescence spectroscopy revealing a broad linear detection range of 0.6-360 nM (R2 = 0.993) and an exceptionally low limit of detection (LOD) of 0.40 nM. The system showed high selectivity toward NIF over structurally similar compounds, drugs, and common metal ions. The sensor was effectively applied for the detection of NIF in urine and Lotus Pond water samples, highlighting its potential for practical pharmacological monitoring. This study presents a sustainable and effective approach for fabricating DES-assisted 2D nanosheets for trace-level analyte detection.
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BibTeX
@article{ullah2026desbased,
title = {{DES-Based Green Synthesis of 2D Fluorescent Molybdenum Disulfide for Highly Sensitive and Selective Detection of Nifedipine.}},
author = {Rafee Ullah and Shams Ur Rehman and Adnan Khan and Hui-Fen Wu},
journal = {Analytical chemistry},
year = {2026},
month = oct,
doi = {10.1021/acs.analchem.6c02269},
url = {https://europepmc.org/article/MED/42899538},
note = {CC BY},
}
RIS
TY - JOUR
TI - DES-Based Green Synthesis of 2D Fluorescent Molybdenum Disulfide for Highly Sensitive and Selective Detection of Nifedipine.
AU - Rafee Ullah
AU - Shams Ur Rehman
AU - Adnan Khan
AU - Hui-Fen Wu
PY - 2026
DA - 2026/10/01
JO - Analytical chemistry
DO - 10.1021/acs.analchem.6c02269
UR - https://europepmc.org/article/MED/42899538
AB - Highly fluorescent 2D MoS2-x nanosheets exhibiting intense blue emission were synthesized using a green chemistry approach, utilizing DES as both the reaction medium and a surface passivating agent. The material was synthesized via a hydrothermal method, followed by ultrasonication-assisted exfoliation to yield ultrathin nanosheets with enhanced photoluminescence properties. The 2D MoS2-x nanosheets demonstrated strong fluorescence at λem = 420 nm when excited at λex = 330 nm. These nanosheets were employed as a fluorescence probe for the detection of the calcium channel blocker drug nifedipine (NIF) via a fluorescence quenching mechanism. Upon addition of NIF, the fluorescence of the 2D MoS2-x nanosheets was quenched due to electron transfer from the nanosheets to the electron-deficient NIF molecules, combined with the inner filter effect (IFE). The nanosheets enabled highly sensitive and selective detection of NIF, with photoluminescence spectroscopy revealing a broad linear detection range of 0.6-360 nM (R2 = 0.993) and an exceptionally low limit of detection (LOD) of 0.40 nM. The system showed high selectivity toward NIF over structurally similar compounds, drugs, and common metal ions. The sensor was effectively applied for the detection of NIF in urine and Lotus Pond water samples, highlighting its potential for practical pharmacological monitoring. This study presents a sustainable and effective approach for fabricating DES-assisted 2D nanosheets for trace-level analyte detection.
SN - 0003-2700
SN - 1520-6882
ER -