Studying Biologically Important Monovalent Cation Diffusion across Lipids Using Molecular Fe Redox Reporters in Hybrid Bilayer Membranes
4 affiliations
- 1Department of Chemistry
- 2University of Hong Kong
- 3Centre for Condensed Matter Sciences and Centre of Atomic Initiative for New Materials
- 4National Taiwan University
Abstract
We developed a new hybrid bilayer membrane (HBM) platform, Fe(TPY)(CN)3 HBM, incorporating mononuclear Fe complexes chelated by tridentate 2,2':6',2''-terpyridine-4'-oxy-hexane-1-thiol (TPY) ligands and cyanide (CN–) ligands on an Au electrode, forming a stable and robust octahedral complex, covered by a monolayer of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) lipids, to study the transmembrane diffusion behaviours of monovalent cations, Li+, Na+, K+ and NH4+. The most positive shift in the half-wave potential (E1/2) of Fe3+/2+ redox occurred in presence of Li+, following the descending trend of Li+ > NH4+ > Na+ > K+. On the other hand, the Fe3+/2+ redox exhibited the largest peak separation (ΔE) in presence of Li+, which follows the same descending order. These trends highlight that the transmembrane diffusion mechanism for the monovalent cations studied is governed by interplay of charge density, intermolecular interactions, dehydration energy, and interfacial steric hindrance.
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BibTeX
@misc{yau2026studying,
title = {{Studying Biologically Important Monovalent Cation Diffusion across Lipids Using Molecular Fe Redox Reporters in Hybrid Bilayer Membranes}},
author = {Hei Tung Yau and Zuo Hang Yu and Xiaoyong Mo and Sheng-Yu Yu and Heng-Liang Wu and Edmund C. M. Tse},
howpublished = {ChemRxiv},
year = {2026},
month = sep,
doi = {10.26434/chemrxiv.15008176/v1},
url = {https://chemrxiv.org/doi/full/10.26434/chemrxiv.15008176/v1},
note = {CC BY-NC-ND},
}
RIS
TY - UNPB
TI - Studying Biologically Important Monovalent Cation Diffusion across Lipids Using Molecular Fe Redox Reporters in Hybrid Bilayer Membranes
AU - Hei Tung Yau
AU - Zuo Hang Yu
AU - Xiaoyong Mo
AU - Sheng-Yu Yu
AU - Heng-Liang Wu
AU - Edmund C. M. Tse
PY - 2026
DA - 2026/09/01
PB - ChemRxiv
DO - 10.26434/chemrxiv.15008176/v1
UR - https://chemrxiv.org/doi/full/10.26434/chemrxiv.15008176/v1
AB - We developed a new hybrid bilayer membrane (HBM) platform, Fe(TPY)(CN)3 HBM, incorporating mononuclear Fe complexes chelated by tridentate 2,2':6',2''-terpyridine-4'-oxy-hexane-1-thiol (TPY) ligands and cyanide (CN–) ligands on an Au electrode, forming a stable and robust octahedral complex, covered by a monolayer of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) lipids, to study the transmembrane diffusion behaviours of monovalent cations, Li+, Na+, K+ and NH4+. The most positive shift in the half-wave potential (E1/2) of Fe3+/2+ redox occurred in presence of Li+, following the descending trend of Li+ > NH4+ > Na+ > K+. On the other hand, the Fe3+/2+ redox exhibited the largest peak separation (ΔE) in presence of Li+, which follows the same descending order. These trends highlight that the transmembrane diffusion mechanism for the monovalent cations studied is governed by interplay of charge density, intermolecular interactions, dehydration energy, and interfacial steric hindrance.
ER -