Kidney Function Trajectories in Patients with and Without Chronic Kidney Disease Undergoing Transcatheter Aortic Valve Replacement: A Single-Retrospective Cohort Study
- 1Division of Cardiology and Nephrology, Department of Internal Medicine, Asahikawa Medical University, Midorigaoka-Higashi 2-1-1-1, Asahikawa 078-8510, Japan
- 2Department of Integrative Nephrology and Therapeutics, Asahikawa Medical University, Midorigaoka-Higashi 2-1-1-1, Asahikawa 078-8510, Japan
- 3Department of Cardiac Surgery, Asahikawa Medical University, Midorigaoka-Higashi 2-1-1-1, Asahikawa 078-8510, Japan
Abstract
Background/Objectives: Transcatheter aortic valve replacement (TAVR) may improve systemic hemodynamics and kidney perfusion; however, its effect on long-term kidney function remains unclear. We evaluated kidney function trajectories before and after TAVR in patients with and without chronic kidney disease (CKD). Methods: This single-center retrospective cohort study included patients with severe aortic stenosis (AS) who underwent TAVR between June 2016 and December 2024. Overall, 314 eligible patients were classified by baseline estimated glomerular filtration rate (eGFR) as without CKD (≥60 mL/min/1.73 m2) or with CKD (<60 mL/min/1.73 m2). Linear mixed-effects models estimated pre- and post-TAVR eGFR slopes, which were compared between groups after covariate adjustment. Results: Median follow-up was 2.0 years. Adjusted pre-TAVR eGFR slopes were −2.11 (95% confidence interval [CI], −3.34 to −0.89) mL/min/1.73 m2/year in patients without CKD and −2.83 (95% CI, −3.65 to −2.01) mL/min/1.73 m2/year in patients with CKD. The post-TAVR slopes were −4.02 (95% CI, −5.68 to −2.35) mL/min/1.73 m2/year in patients without CKD and −0.83 (95% CI, −2.04 to 0.39) mL/min/1.73 m2/year in patients with CKD, with a significant group difference of 3.19 (95% CI, 1.44 to 4.94) mL/min/1.73 m2/year (p < 0.001). In patients with CKD, the post-TAVR slope improved relative to the pre-TAVR slope by 2.01 (95% CI, 0.51 to 3.50) mL/min/1.73 m2/year (p < 0.01), whereas no significant change was observed in those without CKD. Conclusions: eGFR decline after TAVR was attenuated in patients with CKD compared with those without CKD, suggesting that kidney function may be preserved through hemodynamic improvement following TAVR.
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BibTeX
@article{sakuma2026kidney,
title = {{Kidney Function Trajectories in Patients with and Without Chronic Kidney Disease Undergoing Transcatheter Aortic Valve Replacement: A Single-Retrospective Cohort Study}},
author = {Hirofumi Sakuma and Satoshi Kawaguchi and Yuya Kitani and Tatsuya Aonuma and Naoko Kawabata and Erika Saito and Akiho Minoshima and Shingo Kunioka and Hiroyuki Kamiya and Naoki Nakagawa},
journal = {Journal of clinical medicine},
year = {2026},
month = oct,
doi = {10.3390/jcm15197656},
url = {https://europepmc.org/article/PMC/PMC13666079},
note = {CC BY},
}
RIS
TY - JOUR
TI - Kidney Function Trajectories in Patients with and Without Chronic Kidney Disease Undergoing Transcatheter Aortic Valve Replacement: A Single-Retrospective Cohort Study
AU - Hirofumi Sakuma
AU - Satoshi Kawaguchi
AU - Yuya Kitani
AU - Tatsuya Aonuma
AU - Naoko Kawabata
AU - Erika Saito
AU - Akiho Minoshima
AU - Shingo Kunioka
AU - Hiroyuki Kamiya
AU - Naoki Nakagawa
PY - 2026
DA - 2026/10/01
JO - Journal of clinical medicine
DO - 10.3390/jcm15197656
UR - https://europepmc.org/article/PMC/PMC13666079
AB - Background/Objectives: Transcatheter aortic valve replacement (TAVR) may improve systemic hemodynamics and kidney perfusion; however, its effect on long-term kidney function remains unclear. We evaluated kidney function trajectories before and after TAVR in patients with and without chronic kidney disease (CKD). Methods: This single-center retrospective cohort study included patients with severe aortic stenosis (AS) who underwent TAVR between June 2016 and December 2024. Overall, 314 eligible patients were classified by baseline estimated glomerular filtration rate (eGFR) as without CKD (≥60 mL/min/1.73 m2) or with CKD (<60 mL/min/1.73 m2). Linear mixed-effects models estimated pre- and post-TAVR eGFR slopes, which were compared between groups after covariate adjustment. Results: Median follow-up was 2.0 years. Adjusted pre-TAVR eGFR slopes were −2.11 (95% confidence interval [CI], −3.34 to −0.89) mL/min/1.73 m2/year in patients without CKD and −2.83 (95% CI, −3.65 to −2.01) mL/min/1.73 m2/year in patients with CKD. The post-TAVR slopes were −4.02 (95% CI, −5.68 to −2.35) mL/min/1.73 m2/year in patients without CKD and −0.83 (95% CI, −2.04 to 0.39) mL/min/1.73 m2/year in patients with CKD, with a significant group difference of 3.19 (95% CI, 1.44 to 4.94) mL/min/1.73 m2/year (p < 0.001). In patients with CKD, the post-TAVR slope improved relative to the pre-TAVR slope by 2.01 (95% CI, 0.51 to 3.50) mL/min/1.73 m2/year (p < 0.01), whereas no significant change was observed in those without CKD. Conclusions: eGFR decline after TAVR was attenuated in patients with CKD compared with those without CKD, suggesting that kidney function may be preserved through hemodynamic improvement following TAVR.
SN - 2077-0383
ER -