Association of preoperative forced vital capacity with prolonged mechanical ventilation after coronary artery bypass grafting: a retrospective cohort Study.
7 affiliations
- 1Department of Cardiovascular Surgery, Beijing Anzhen Hospital, Capital Medical University, No. 2 Anzhen Street, Chaoyang District, Beijing, 100029, China.
- 2Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, China.
- 3Department of Nursing, Beijing Anzhen Hospital, Capital Medical University, No.2 Anzhen Street, Beijing, Chaoyang District, 100029, China.
- 4Department of Cardiovascular Surgery, Beijing Anzhen Hospital, Capital Medical University, No. 2 Anzhen Street, Chaoyang District, Beijing, 100029, China. [email protected].
- 5Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, China. [email protected].
- 6Department of Cardiovascular Surgery, Beijing Anzhen Hospital, Capital Medical University, No. 2 Anzhen Street, Chaoyang District, Beijing, 100029, China. [email protected].
- 7Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, China. [email protected].
Abstract
Background
Prolonged mechanical ventilation (PMV) is a serious complication after coronary artery bypass grafting (CABG), yet the association between preoperative pulmonary function and PMV risk remains to be comprehensively evaluated.Methods
This study included adult patients who underwent isolated CABG with preoperative pulmonary function testing. Predicted forced vital capacity (FVC), predicted forced expiratory volume in 1 s (FEV₁), and the FEV₁/FVC ratio were assessed for their association with PMV.Results
Among 1,702 patients, 151 (8.9%) experienced PMV. Patients with PMV were older (65.1 ± 8.5 vs. 62.8 ± 8.8 years, P = 0.003), had higher rates of chronic obstructive pulmonary disease (9.9% vs. 5.4%, P = 0.034) and on-pump CABG (8.6% vs. 1.2%, P < 0.001), lower left ventricular ejection fraction (57.1 ± 10.3% vs. 59.1 ± 8.7%, P = 0.007), lower predicted FVC (82.9 ± 14.0% vs. 88.1 ± 14.9%, P < 0.001), and lower predicted FEV₁ (88.7 ± 15.5% vs. 92.6 ± 16.2%, P = 0.007). They also had higher perioperative mortality (4.0% vs. 0.1%, P < 0.001), longer postoperative hospital stays (10.9 ± 4.2 vs. 8.0 ± 2.6 days, P < 0.001), and greater hospitalization costs (25,309.4 [22,119.4-33,359.3] vs. 18,155.4 [16,665.8-20,001.5] USD, P < 0.001). Restricted cubic spline analysis showed no non-linear relationship between pulmonary function parameters and PMV. After multivariable adjustment, predicted FVC remained independently associated with PMV (odds ratio [OR] 0.97, 95% confidence interval [CI] 0.95-0.99, P = 0.005), whereas predicted FEV₁ did not.Conclusions
Nearly one-tenth of patients undergoing CABG required PMV, which was associated with greater healthcare resource utilization and higher perioperative complications. Predicted FVC, but not predicted FEV₁, is an independent predictor of PMV.
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BibTeX
@article{he2026association,
title = {{Association of preoperative forced vital capacity with prolonged mechanical ventilation after coronary artery bypass grafting: a retrospective cohort Study.}},
author = {Meng He and Liaoming He and Jinwei Zhang and Yajing Xu and Xiwei Zhang and Xiaoting Li and Jing Nie and Yongqiang Lai and Changwei Ren and Hao Cui},
journal = {BMC anesthesiology},
year = {2026},
month = jul,
doi = {10.1186/s12871-026-04090-6},
url = {https://europepmc.org/article/MED/42897475},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Association of preoperative forced vital capacity with prolonged mechanical ventilation after coronary artery bypass grafting: a retrospective cohort Study.
AU - Meng He
AU - Liaoming He
AU - Jinwei Zhang
AU - Yajing Xu
AU - Xiwei Zhang
AU - Xiaoting Li
AU - Jing Nie
AU - Yongqiang Lai
AU - Changwei Ren
AU - Hao Cui
PY - 2026
DA - 2026/07/01
JO - BMC anesthesiology
DO - 10.1186/s12871-026-04090-6
UR - https://europepmc.org/article/MED/42897475
AB - Background Prolonged mechanical ventilation (PMV) is a serious complication after coronary artery bypass grafting (CABG), yet the association between preoperative pulmonary function and PMV risk remains to be comprehensively evaluated.Methods This study included adult patients who underwent isolated CABG with preoperative pulmonary function testing. Predicted forced vital capacity (FVC), predicted forced expiratory volume in 1 s (FEV₁), and the FEV₁/FVC ratio were assessed for their association with PMV.Results Among 1,702 patients, 151 (8.9%) experienced PMV. Patients with PMV were older (65.1 ± 8.5 vs. 62.8 ± 8.8 years, P = 0.003), had higher rates of chronic obstructive pulmonary disease (9.9% vs. 5.4%, P = 0.034) and on-pump CABG (8.6% vs. 1.2%, P < 0.001), lower left ventricular ejection fraction (57.1 ± 10.3% vs. 59.1 ± 8.7%, P = 0.007), lower predicted FVC (82.9 ± 14.0% vs. 88.1 ± 14.9%, P < 0.001), and lower predicted FEV₁ (88.7 ± 15.5% vs. 92.6 ± 16.2%, P = 0.007). They also had higher perioperative mortality (4.0% vs. 0.1%, P < 0.001), longer postoperative hospital stays (10.9 ± 4.2 vs. 8.0 ± 2.6 days, P < 0.001), and greater hospitalization costs (25,309.4 [22,119.4-33,359.3] vs. 18,155.4 [16,665.8-20,001.5] USD, P < 0.001). Restricted cubic spline analysis showed no non-linear relationship between pulmonary function parameters and PMV. After multivariable adjustment, predicted FVC remained independently associated with PMV (odds ratio [OR] 0.97, 95% confidence interval [CI] 0.95-0.99, P = 0.005), whereas predicted FEV₁ did not.Conclusions Nearly one-tenth of patients undergoing CABG required PMV, which was associated with greater healthcare resource utilization and higher perioperative complications. Predicted FVC, but not predicted FEV₁, is an independent predictor of PMV.
SN - 1471-2253
ER -