The role of injectable porcine type I collagen (Tropocollagen) in chronic musculoskeletal disorders.
- 1Department of Musculoskeletal Disorders, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland. [email protected].
Abstract
The aim of this narrative review is to present current data on the use of porcine type I collagen (tropocollagen) injections in the treatment of chronic musculoskeletal disorders, with particular emphasis on its clinical application and safety profile. A search was conducted in the Medline/PubMed, Scopus, and Directory of Open Access Journals (DOAJ) databases. Based on inclusion and exclusion criteria, 14 publications were identified. The available studies cover the use of collagen administered intra-articularly, periarticularly, and via mesotherapy. The analyzed publications reported improvements in clinical symptoms and function in various chronic musculoskeletal conditions, accompanied by a favorable safety profile. However, it should be emphasized that the available clinical evidence is limited by small sample sizes, heterogeneity in treatment protocols, and a relatively short follow-up period. Injectable porcine type I collagen is a promising adjunctive treatment for chronic musculoskeletal disorders; however, further, well-designed randomized clinical trials with larger patient cohorts and longer follow-up periods are necessary.
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BibTeX
@article{koszela2026role,
title = {{The role of injectable porcine type I collagen (Tropocollagen) in chronic musculoskeletal disorders.}},
author = {Kamil Koszela},
journal = {Rheumatology international},
year = {2026},
month = oct,
doi = {10.1007/s00296-026-06326-7},
url = {https://europepmc.org/article/MED/42853282},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - The role of injectable porcine type I collagen (Tropocollagen) in chronic musculoskeletal disorders.
AU - Kamil Koszela
PY - 2026
DA - 2026/10/09
JO - Rheumatology international
DO - 10.1007/s00296-026-06326-7
UR - https://europepmc.org/article/MED/42853282
AB - The aim of this narrative review is to present current data on the use of porcine type I collagen (tropocollagen) injections in the treatment of chronic musculoskeletal disorders, with particular emphasis on its clinical application and safety profile. A search was conducted in the Medline/PubMed, Scopus, and Directory of Open Access Journals (DOAJ) databases. Based on inclusion and exclusion criteria, 14 publications were identified. The available studies cover the use of collagen administered intra-articularly, periarticularly, and via mesotherapy. The analyzed publications reported improvements in clinical symptoms and function in various chronic musculoskeletal conditions, accompanied by a favorable safety profile. However, it should be emphasized that the available clinical evidence is limited by small sample sizes, heterogeneity in treatment protocols, and a relatively short follow-up period. Injectable porcine type I collagen is a promising adjunctive treatment for chronic musculoskeletal disorders; however, further, well-designed randomized clinical trials with larger patient cohorts and longer follow-up periods are necessary.
SN - 0172-8172
SN - 1437-160X
ER -