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Peer-reviewedCC BY-NC 4.0Dermatology and Therapy

Dermocosmetics for Periocular Aging: Evidence, Mechanisms, and Integration with Aesthetic Procedures. A Narrative Review

  • Ludmila Prudkin1
  • Jaime Piquero-Casals2
  • Jaime Rengifo-Palacios3
  • Daniela Maleh4
  • Anthony Brown1
  • Denise Steiner5
  • José Luis López Estebaranz6
6 affiliations
  1. 1Innovation and Development, ISDIN, Provençals 33, 08019 Barcelona, Spain
  2. 2Department of Dermatology, Dermacentric Health and Aesthetics, Barcelona, Spain
  3. 3Department of Dermatology, Universidad Pontificia Bolivariana, Medellín, Colombia
  4. 4Duoderma Dermatología y Estética, Buenos Aires, Argentina
  5. 5Department of Dermatology, University of Mogi das Cruzes, Mogi das Cruzes, Brazil
  6. 6Dermatology Department, Hospital Universitario Fundación Alcorcón, Madrid, Spain
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Abstract

The periocular area, where facial skin is thinnest and most expressive, is often the first to reveal signs of aging. Aesthetic procedures can correct structural changes, but they do not replace daily, ongoing care. Dermocosmetics formulated specifically for the eye contour have become a standard complement to medical-aesthetic treatments, with potential preventive, corrective, and maintenance benefits. This narrative review summarizes the evidence on the efficacy and safety of these products and their role in a comprehensive approach to periocular rejuvenation. A literature search in PubMed (2010–2025) identified randomized trials, observational studies, and mechanistic research on periocular anatomy, active ingredients, and clinical outcomes. Retinoids, peptides, antioxidants, vasomodulators, and depigmenting agents improve hydration, firmness, pigment uniformity, and puffiness, particularly alongside aesthetic procedures. Most available studies, however, derive from finished multicomponent formulations rather than isolated ingredients; studies are short-term, industry-sponsored, and limited in participant diversity and endpoints, so further independent, long-term, periocular-specific studies are needed. Dermocosmetics for the eye contour may provide a noninvasive strategy that supports skin resilience and complements procedures within a comprehensive periocular rejuvenation strategy. Closer collaboration between dermatologists, aesthetic physicians, and cosmetic formulators would help translate this evidence into more consistent periocular rejuvenation outcomes.

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Cite

BibTeXRIS
BibTeX
@article{prudkin2026dermocosmetics,
  title = {{Dermocosmetics for Periocular Aging: Evidence, Mechanisms, and Integration with Aesthetic Procedures. A Narrative Review}},
  author = {Ludmila Prudkin and Jaime Piquero-Casals and Jaime Rengifo-Palacios and Daniela Maleh and Anthony Brown and Denise Steiner and José Luis López Estebaranz},
  journal = {Dermatology and Therapy},
  year = {2026},
  month = sep,
  doi = {10.1007/s13555-026-01934-4},
  url = {https://doi.org/10.1007/s13555-026-01934-4},
  note = {CC BY-NC 4.0},
}
RIS
TY  - JOUR
TI  - Dermocosmetics for Periocular Aging: Evidence, Mechanisms, and Integration with Aesthetic Procedures. A Narrative Review
AU  - Ludmila Prudkin
AU  - Jaime Piquero-Casals
AU  - Jaime Rengifo-Palacios
AU  - Daniela Maleh
AU  - Anthony Brown
AU  - Denise Steiner
AU  - José Luis López Estebaranz
PY  - 2026
DA  - 2026/09/01
JO  - Dermatology and Therapy
DO  - 10.1007/s13555-026-01934-4
UR  - https://doi.org/10.1007/s13555-026-01934-4
AB  - The periocular area, where facial skin is thinnest and most expressive, is often the first to reveal signs of aging. Aesthetic procedures can correct structural changes, but they do not replace daily, ongoing care. Dermocosmetics formulated specifically for the eye contour have become a standard complement to medical-aesthetic treatments, with potential preventive, corrective, and maintenance benefits. This narrative review summarizes the evidence on the efficacy and safety of these products and their role in a comprehensive approach to periocular rejuvenation. A literature search in PubMed (2010–2025) identified randomized trials, observational studies, and mechanistic research on periocular anatomy, active ingredients, and clinical outcomes. Retinoids, peptides, antioxidants, vasomodulators, and depigmenting agents improve hydration, firmness, pigment uniformity, and puffiness, particularly alongside aesthetic procedures. Most available studies, however, derive from finished multicomponent formulations rather than isolated ingredients; studies are short-term, industry-sponsored, and limited in participant diversity and endpoints, so further independent, long-term, periocular-specific studies are needed. Dermocosmetics for the eye contour may provide a noninvasive strategy that supports skin resilience and complements procedures within a comprehensive periocular rejuvenation strategy. Closer collaboration between dermatologists, aesthetic physicians, and cosmetic formulators would help translate this evidence into more consistent periocular rejuvenation outcomes.
SN  - 2193-8210
SN  - 2190-9172
ER  -