Biomimetic electrospun nanofibrous composites for bone tissue engineering: a review of materials, fabrication, and applications.
8 affiliations
- 1Department of Chemistry, Vellore Institute of Technology, Vellore, Tamil Nadu, 632014, India.
- 2Department of Chemistry, Faculty of Engineering and Technology, SRM Institute Science and Technology, Bharathi Salai, Ramapuram, Chennai, Tamil Nadu, 600089, India.
- 3Nanomaterials Laboratory, Department of Chemistry, Kalasalingam Academy of Research and Education, Krishnankoil, Tamil Nadu, 626126, India.
- 4Department of Chemistry, Faculty of Engineering and Technology, SRM Institute Science and Technology, Bharathi Salai, Ramapuram, Chennai, Tamil Nadu, 600089, India. [email protected].
- 5Department of Chemistry, Karpagam Academy of Higher Education, Coimbatore, Tamil Nadu, 641021, India. [email protected].
- 6Centre for Advanced Solar Cell Technologies, Karpagam Academy of Higher Education, Coimbatore, Tamil Nadu, 641021, India. [email protected].
- 7Department of Electrical Engineering, College of Engineering, University of Bisha, P.O. Box 551, 61922, Bisha, Saudi Arabia.
- 8Department of Mechanical Engineering, Adama Science and Technology University, 2552, Adama, Ethiopia. [email protected].
Abstract
A flexible and promising method for creating polymeric nanofibrous composites for BTE (bone tissue engineering) is electrospinning. The optimal composites should resemble bone's natural ECM (extracellular matrix), possess suitable surface chemistry, exhibit strong mechanical strength, and demonstrate bioactivity and biocompatibility. Selecting the appropriate material for composite fabrication is a critical initial step in developing a BTE (tissue engineered) product. BTE is a multidisciplinary area that applies engineering concepts to bone-related biological processes. Key considerations in this field include composites, cells, growth factors, and their interfaces in the microenvironment. This review article examines the recent developments in BTE using biomimetic electrospun polymeric biomaterials. It provides an overview of Natural polymer, synthetic polymer, bone structure, biocomposite discusses the ideal characteristics of bone scaffolds, and offers a basic introduction to BTE. The fabrication of bone composites is explored in detail, including various materials and techniques used. Additionally covered the characteristics, benefits, and uses of electrospinning in BTE. The application of electrospun nanofibrous composites composed of natural and synthetic polymers for BTE is thoroughly reviewed and discussed, as well as the biomineralization processes involved. Finally, the study concludes with insights into biomimetic composites for BTE based on electrospun nanofibers.
Related
- Acoustic Optimization and Standardized Fabrication of a Biomimetic Liver Phantom for Quantitative Multimodal Imaging
- Biodegradable electrospun PLLA/HA-ATE composite polypropylene scaffold for hernia repair applications.
- Niallia Circulans mediated Bio-fabrication of ZnO nanoparticles: Synthesis, characterization, and multifunctional applications
- Artificial Intelligence in Civil Engineering a Comprehensive Review of Applications, Challenges, and Future Directions
- Hyaluronic Acid-Based Biomaterials in Tissue Engineering: From Molecular Properties to Re-Generative Applications
BibTeX
@article{valarmathi2026biomimetic,
title = {{Biomimetic electrospun nanofibrous composites for bone tissue engineering: a review of materials, fabrication, and applications.}},
author = {N Valarmathi and S Sumathi and Helen P Kavitha and M Swaminathan and Manikandan Krishnamurthy and Manikandan Ayyar and Abdullatif Hakami and Abinet Gosaye Ayanie},
journal = {Biomedical engineering online},
year = {2026},
month = jul,
doi = {10.1186/s12938-026-01596-5},
url = {https://europepmc.org/article/MED/42897607},
note = {CC BY},
}
RIS
TY - JOUR
TI - Biomimetic electrospun nanofibrous composites for bone tissue engineering: a review of materials, fabrication, and applications.
AU - N Valarmathi
AU - S Sumathi
AU - Helen P Kavitha
AU - M Swaminathan
AU - Manikandan Krishnamurthy
AU - Manikandan Ayyar
AU - Abdullatif Hakami
AU - Abinet Gosaye Ayanie
PY - 2026
DA - 2026/07/01
JO - Biomedical engineering online
DO - 10.1186/s12938-026-01596-5
UR - https://europepmc.org/article/MED/42897607
AB - A flexible and promising method for creating polymeric nanofibrous composites for BTE (bone tissue engineering) is electrospinning. The optimal composites should resemble bone's natural ECM (extracellular matrix), possess suitable surface chemistry, exhibit strong mechanical strength, and demonstrate bioactivity and biocompatibility. Selecting the appropriate material for composite fabrication is a critical initial step in developing a BTE (tissue engineered) product. BTE is a multidisciplinary area that applies engineering concepts to bone-related biological processes. Key considerations in this field include composites, cells, growth factors, and their interfaces in the microenvironment. This review article examines the recent developments in BTE using biomimetic electrospun polymeric biomaterials. It provides an overview of Natural polymer, synthetic polymer, bone structure, biocomposite discusses the ideal characteristics of bone scaffolds, and offers a basic introduction to BTE. The fabrication of bone composites is explored in detail, including various materials and techniques used. Additionally covered the characteristics, benefits, and uses of electrospinning in BTE. The application of electrospun nanofibrous composites composed of natural and synthetic polymers for BTE is thoroughly reviewed and discussed, as well as the biomineralization processes involved. Finally, the study concludes with insights into biomimetic composites for BTE based on electrospun nanofibers.
SN - 1475-925X
ER -