Association of a history of type 2 diabetes with short-term mortality in patients with decompensated cirrhosis.
5 affiliations
- 1Department of Gastroenterology, Maanshan People's Hospital, Maanshan, Anhui, China.
- 2Department of Gastroenterology, The First Affiliated Hospital of Wannan Medical University (Yijishan Hospital of Wannan Medical University), Wuhu, Anhui, China.
- 3Department of Gastroenterology, The Second Affiliated Hospital of Wannan Medical University, Wuhu, Anhui, China.
- 4Department of Gastroenterology, The First People's Hospital of Wuhu, Wuhu, Anhui, China.
- 5Department of Gastroenterology, Affiliated Hospital of West Anhui Health Vocational College, Lu'an, Anhui, China.
Abstract
Background
The association between type 2 diabetes mellitus (T2DM) and mortality in patients with liver cirrhosis remains controversial. This study aimed to evaluate whether a history of T2DM influences short-term all-cause mortality in hospitalized patients with decompensated liver cirrhosis (DLC).Methods
We conducted a retrospective study of hospitalized patients with DLC at three medical centers in China between November 2019 and June 2024. The study endpoint was the 6-month mortality. The association between T2DM and mortality was assessed using multivariable logistic regression, and stabilized inverse probability of treatment weighting (sIPTW) analysis was applied for sensitivity analysis.Results
Among 984 eligible patients, 239 (24.3%) had a history of T2DM. Patients with T2DM were older and had a higher prevalence of hypertension and coronary artery disease; however, no significant difference in 6-month mortality was observed between patients with and without T2DM. Multivariable logistic regression showed no independent association between a history of T2DM and mortality (OR = 0.80, 95% CI: 0.51-1.23), this result remained consistent using sIPTW analysis (OR = 0.78, 95% CI: 0.51-1.21).Conclusions
A history of T2DM may not be independently associated with short-term mortality in patients with DLC. These findings suggest that T2DM status may not be prioritized over liver-specific prognostic factors when assessing the short-term mortality risk in patients with DLC.
Related
- Plasma Cystatin C as a Marker of Acute-on-Chronic Liver Failure and 28-Day Mortality in Patients With Acutely Decompensated Liver Cirrhosis: A Prospective Observational Study
- Association of Baseline and Serial High-Sensitivity Cardiac Troponin T with In-Hospital Mortality Across Clinical Presentation, LVEF and Diabetes Status in Decompensated Heart Failure
- Randomised, double-blind, placebo-controlled trial of faecal microbiota transplantation in patients with decompensated cirrhosis: the Livergut protocol.
- Dysregulation of the serum and IgG N-glycome in decompensated cirrhosis and its association with Model for End-Stage Liver Disease-Sodium (MELD-Na)
- Nutritional status, health literacy, and lifestyle factors associated with health-related quality of life in patients with decompensated cirrhosis: a cross-sectional study.
BibTeX
@article{ju2026association,
title = {{Association of a history of type 2 diabetes with short-term mortality in patients with decompensated cirrhosis.}},
author = {Honglei Ju and Guixiang Wang and Yujie Zhang and Bo Sun and Chiyi He and Jin Cheng and Wei Wang},
journal = {Frontiers in endocrinology},
year = {2026},
month = oct,
doi = {10.3389/fendo.2026.1971737},
url = {https://europepmc.org/article/MED/42908653},
note = {CC BY},
}
RIS
TY - JOUR
TI - Association of a history of type 2 diabetes with short-term mortality in patients with decompensated cirrhosis.
AU - Honglei Ju
AU - Guixiang Wang
AU - Yujie Zhang
AU - Bo Sun
AU - Chiyi He
AU - Jin Cheng
AU - Wei Wang
PY - 2026
DA - 2026/10/07
JO - Frontiers in endocrinology
DO - 10.3389/fendo.2026.1971737
UR - https://europepmc.org/article/MED/42908653
AB - Background The association between type 2 diabetes mellitus (T2DM) and mortality in patients with liver cirrhosis remains controversial. This study aimed to evaluate whether a history of T2DM influences short-term all-cause mortality in hospitalized patients with decompensated liver cirrhosis (DLC).Methods We conducted a retrospective study of hospitalized patients with DLC at three medical centers in China between November 2019 and June 2024. The study endpoint was the 6-month mortality. The association between T2DM and mortality was assessed using multivariable logistic regression, and stabilized inverse probability of treatment weighting (sIPTW) analysis was applied for sensitivity analysis.Results Among 984 eligible patients, 239 (24.3%) had a history of T2DM. Patients with T2DM were older and had a higher prevalence of hypertension and coronary artery disease; however, no significant difference in 6-month mortality was observed between patients with and without T2DM. Multivariable logistic regression showed no independent association between a history of T2DM and mortality (OR = 0.80, 95% CI: 0.51-1.23), this result remained consistent using sIPTW analysis (OR = 0.78, 95% CI: 0.51-1.21).Conclusions A history of T2DM may not be independently associated with short-term mortality in patients with DLC. These findings suggest that T2DM status may not be prioritized over liver-specific prognostic factors when assessing the short-term mortality risk in patients with DLC.
SN - 1664-2392
ER -