Peer-reviewedCC BY-NC-SAGAIMS Journal of Medical Sciences23 Oct 2026

Efficacy of Platelet-Rich Plasma (PRP) in Androgenetic Alopecia, Acne Scars, and Non-Healing Ulcers: A Prospective Interventional Study

Krunal Dudhatra¹
Jui Shah²
Mansi Pithadia³
Devendra Parmar²
Meera Patel⁴
Prerakkumar Kathiriya⁵

5 affiliations

¹Assure Clinic, Ahmedabad, Gujarat, India
²Department of Dermatology, Venereology & Leprosy, Gujarat Adani Institute of Medical Sciences (GAIMS), GK General Hospital, Bhuj, Kutch, Gujarat, India
³Divine Hospital, Jamnagar, Gujarat, India
⁴Vcare Centre of Excellence, Bengaluru, India
⁵Serenity Skin & Aesthetic Clinic, Rajkot, Gujarat, India

Abstract

Background: Platelet-rich plasma (PRP) is an autologous concentrate obtained by differential centrifugation of whole blood, yielding platelets 4-7 times the baseline concentration with an attendant payload of growth factors including PDGF, VEGF, EGF, FGF, TGF-β, and IGF-1, which promote cellular proliferation, collagen synthesis, and tissue regeneration. Material and Methods: A prospective interventional study enrolling 50 patients (20 androgenetic alopecia [AGA], 15 acne scars, 15 non-healing venous ulcers) was conducted at a tertiary care centre in western India from December 2020 to September 2022. PRP was prepared by the manual double-spin method and administered intralesionally at 15-day intervals for 3 months (6 sessions), with monthly follow-up until 6 months. Outcomes were assessed by physician’s global assessment (7-point scale), Hamilton-Norwood/Ludwig grading (AGA), Goodman and Baron’s scale (acne scars), and wound area and volume measurements. Results: In AGA, 85% showed improvement (mild 45%, moderate 30%, excellent 10%). In acne scars, 73.3% achieved good-to-excellent objective response; 26-50% improvement was most frequent (53.3%). In non-healing venous ulcers, mean wound area reduced by 68% (14.09 cm² to 6.01 cm²) and volume by 66% (4.74 cm³ to 1.61 cm³), with 46.67% achieving excellent response. No serious adverse events were recorded in any group. Conclusion: PRP is a safe, cost-effective, and efficacious autologous treatment for androgenetic alopecia, acne scars, and non-healing venous ulcers with a favourable side-effect profile.

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BibTeX RIS

BibTeX

@article{dudhatra2026efficacy,
  title = {{Efficacy of Platelet-Rich Plasma (PRP) in Androgenetic Alopecia, Acne Scars, and Non-Healing Ulcers: A Prospective Interventional Study}},
  author = {Krunal Dudhatra and Jui Shah and Mansi Pithadia and Devendra Parmar and Meera Patel and Prerakkumar Kathiriya},
  journal = {GAIMS Journal of Medical Sciences},
  year = {2026},
  month = oct,
  doi = {10.5281/zenodo.23470605},
  url = {https://doi.org/10.5281/zenodo.23470605},
  note = {CC BY-NC-SA},
}

RIS

TY  - JOUR
TI  - Efficacy of Platelet-Rich Plasma (PRP) in Androgenetic Alopecia, Acne Scars, and Non-Healing Ulcers: A Prospective Interventional Study
AU  - Krunal Dudhatra
AU  - Jui Shah
AU  - Mansi Pithadia
AU  - Devendra Parmar
AU  - Meera Patel
AU  - Prerakkumar Kathiriya
PY  - 2026
DA  - 2026/10/23
JO  - GAIMS Journal of Medical Sciences
DO  - 10.5281/zenodo.23470605
UR  - https://doi.org/10.5281/zenodo.23470605
AB  - Background: Platelet-rich plasma (PRP) is an autologous concentrate obtained by differential centrifugation of whole blood, yielding platelets 4-7 times the baseline concentration with an attendant payload of growth factors including PDGF, VEGF, EGF, FGF, TGF-β, and IGF-1, which promote cellular proliferation, collagen synthesis, and tissue regeneration. Material and Methods: A prospective interventional study enrolling 50 patients (20 androgenetic alopecia [AGA], 15 acne scars, 15 non-healing venous ulcers) was conducted at a tertiary care centre in western India from December 2020 to September 2022. PRP was prepared by the manual double-spin method and administered intralesionally at 15-day intervals for 3 months (6 sessions), with monthly follow-up until 6 months. Outcomes were assessed by physician’s global assessment (7-point scale), Hamilton-Norwood/Ludwig grading (AGA), Goodman and Baron’s scale (acne scars), and wound area and volume measurements. Results: In AGA, 85% showed improvement (mild 45%, moderate 30%, excellent 10%). In acne scars, 73.3% achieved good-to-excellent objective response; 26-50% improvement was most frequent (53.3%). In non-healing venous ulcers, mean wound area reduced by 68% (14.09 cm² to 6.01 cm²) and volume by 66% (4.74 cm³ to 1.61 cm³), with 46.67% achieving excellent response. No serious adverse events were recorded in any group. Conclusion: PRP is a safe, cost-effective, and efficacious autologous treatment for androgenetic alopecia, acne scars, and non-healing venous ulcers with a favourable side-effect profile.
SN  - 2583-1763
ER  -

Abstract

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