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Peer-reviewedCC BY 4.0International Journal of Paediatric Dentistry

Association Between Hypomineralisation of Second Primary Molars and Tooth Agenesis

  • Débora Juliana de Araújo Lopes1
  • Eloisa Cesario Fernandes2
  • Jaderson Felipe Santos Dantas2
  • Patrícia Bittencourt Santos3
  1. 1Dental School State University of Rio Grande do Norte ‐ UERN Caicó Rio Grande do Norte Brazil
  2. 2Department of Dentistry Federal University of Rio Grande do Norte ‐ UFRN Natal Rio Grande do Norte Brazil
  3. 3Department of Paediatric Dentistry Federal University of Rio Grande do Norte ‐ UFRN Natal Rio Grande do Norte Brazil
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Abstract

Background: Hypomineralisation of second primary molars (HSPM) is an enamel defect with a multifactorial and potentially genetic aetiology. While the association between enamel defects and dental anomalies is a relatively recent area of investigation, it has not yet been explored specifically in cases of HSPM.

Aim: To assess the association between HSPM and tooth agenesis (TA).

Design: A retrospective cross‐sectional study was performed using pre‐treatment records of patients aged 7–12 years. A total of 285 patient records were evaluated. Statistical analyses were performed using the Fisher's exact test and logistic regressions.

Results: A higher prevalence of TA was observed among children with HSPM‐affected teeth (95% CI: 1.07–3.17, φ‐coefficient: 0.238, PR: 1.84). Individuals with severe HSPM had significantly greater odds of TA (OR = 12.47; p < 0.001; 95% CI: 3.47–24.70). Patients with HSPM had a significantly higher likelihood of experiencing TA (OR = 6.97), particularly second premolar agenesis (OR = 11.80; p < 0.001; 95% CI: 2.83–49.10).

Conclusion: An association was found between HSPM and TA, particularly involving mandibular second premolars. Moreover, increased HSPM severity was linked to a higher risk of developing TA.

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Cite

BibTeXRIS
BibTeX
@article{lopes2026association,
  title = {{Association Between Hypomineralisation of Second Primary Molars and Tooth Agenesis}},
  author = {Débora Juliana de Araújo Lopes and Eloisa Cesario Fernandes and Jaderson Felipe Santos Dantas and Patrícia Bittencourt Santos},
  journal = {International Journal of Paediatric Dentistry},
  year = {2026},
  month = sep,
  doi = {10.1111/ipd.70148},
  url = {https://doi.org/10.1111/ipd.70148},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Association Between Hypomineralisation of Second Primary Molars and Tooth Agenesis
AU  - Débora Juliana de Araújo Lopes
AU  - Eloisa Cesario Fernandes
AU  - Jaderson Felipe Santos Dantas
AU  - Patrícia Bittencourt Santos
PY  - 2026
DA  - 2026/09/23
JO  - International Journal of Paediatric Dentistry
DO  - 10.1111/ipd.70148
UR  - https://doi.org/10.1111/ipd.70148
AB  - Background: Hypomineralisation of second primary molars (HSPM) is an enamel defect with a multifactorial and potentially genetic aetiology. While the association between enamel defects and dental anomalies is a relatively recent area of investigation, it has not yet been explored specifically in cases of HSPM.  Aim: To assess the association between HSPM and tooth agenesis (TA).  Design: A retrospective cross‐sectional study was performed using pre‐treatment records of patients aged 7–12 years. A total of 285 patient records were evaluated. Statistical analyses were performed using the Fisher's exact test and logistic regressions.  Results: A higher prevalence of TA was observed among children with HSPM‐affected teeth (95% CI: 1.07–3.17, φ‐coefficient: 0.238, PR: 1.84). Individuals with severe HSPM had significantly greater odds of TA (OR = 12.47; p < 0.001; 95% CI: 3.47–24.70). Patients with HSPM had a significantly higher likelihood of experiencing TA (OR = 6.97), particularly second premolar agenesis (OR = 11.80; p < 0.001; 95% CI: 2.83–49.10).  Conclusion: An association was found between HSPM and TA, particularly involving mandibular second premolars. Moreover, increased HSPM severity was linked to a higher risk of developing TA.
SN  - 0960-7439
SN  - 1365-263X
ER  -