Controllable Single and Double C–F Bond Cleavage for Divergent Synthesis of Fluorinated Pyrroles and γ-Lactams
- 1Lanzhou University , , ,
- 2Sun Yat-sen University , , ,
- 3The Chinese Academy of Sciences , , ,
Abstract
Direct C–F bond functionalization of readily accessible polyfluorinated compounds represents an efficient strategy for constructing complex fluorine-containing molecules. While the controllable cleavage of C–F bonds with high chemoselectivity in perfluoroalkyl groups has posed a significant challenge, we present a photocatalytic method that allows for switchable, substrate-controlled cleavage of single or double C(sp3)-F bonds in perfluoroalkyl iminosulfide, which can be conveniently prepared in one pot from readily available perfluoro carboxylic acids. This chemodivergent strategy enables the production of a variety of rarely accessed fluorinated pyrroles and γ-lactams with high chemoselectivity. This method demonstrates a broad substrate scope and excellent tolerance for functional groups. The successful applications of this methodology to pharmacologically relevant molecules underscore its synthetic potential. Furthermore, the synthesis of a compound containing a trifluoromethyl group and a fluorine atom unit, which serves as an analog useful for preventive or therapeutic applications in psychological disorders, illustrates the utility of this reaction. Mechanistic studies have been performed to elucidate the reaction pathway.
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BibTeX
@article{wang2026controllable,
title = {{Controllable Single and Double C–F Bond Cleavage for Divergent Synthesis of Fluorinated Pyrroles and γ-Lactams}},
author = {Tao Wang and Wan-Zhong Feng and Yuan-Yuan Zong and Xiao-Ling Jin and Junwei Yang and Junmin Zhang and Li-Zhu Wu and Qiang Liu},
journal = {JACS Au},
year = {2026},
month = oct,
doi = {10.1021/jacsau.6c01069},
url = {https://pubs.acs.org/jaaucr/article/doi/10.1021/jacsau.6c01069/5454992/Controllable-Single-and-Double-C-F-Bond-Cleavage},
note = {CC BY-NC-ND 4.0},
}
RIS
TY - JOUR
TI - Controllable Single and Double C–F Bond Cleavage for Divergent Synthesis of Fluorinated Pyrroles and γ-Lactams
AU - Tao Wang
AU - Wan-Zhong Feng
AU - Yuan-Yuan Zong
AU - Xiao-Ling Jin
AU - Junwei Yang
AU - Junmin Zhang
AU - Li-Zhu Wu
AU - Qiang Liu
PY - 2026
DA - 2026/10/21
JO - JACS Au
DO - 10.1021/jacsau.6c01069
UR - https://pubs.acs.org/jaaucr/article/doi/10.1021/jacsau.6c01069/5454992/Controllable-Single-and-Double-C-F-Bond-Cleavage
AB - Direct C–F bond functionalization of readily accessible polyfluorinated compounds represents an efficient strategy for constructing complex fluorine-containing molecules. While the controllable cleavage of C–F bonds with high chemoselectivity in perfluoroalkyl groups has posed a significant challenge, we present a photocatalytic method that allows for switchable, substrate-controlled cleavage of single or double C(sp3)-F bonds in perfluoroalkyl iminosulfide, which can be conveniently prepared in one pot from readily available perfluoro carboxylic acids. This chemodivergent strategy enables the production of a variety of rarely accessed fluorinated pyrroles and γ-lactams with high chemoselectivity. This method demonstrates a broad substrate scope and excellent tolerance for functional groups. The successful applications of this methodology to pharmacologically relevant molecules underscore its synthetic potential. Furthermore, the synthesis of a compound containing a trifluoromethyl group and a fluorine atom unit, which serves as an analog useful for preventive or therapeutic applications in psychological disorders, illustrates the utility of this reaction. Mechanistic studies have been performed to elucidate the reaction pathway.
SN - 2691-3704
ER -