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Peer-reviewedCC BY-NC-SA 4.0Veterinary Research Forum

Spontaneous primary B cell lymphoblastic lymphoma of the spleen of a 24-month-old male C57BL/6 mouse

  • Soo-Eun Sung1
  • Minkyoung Sung1
  • Kyung-Ku Kang1
  • Jae Woo Park1
  • Ye-jin Kim1
  • Sun Hee Park2
  • Duyeol Kim2
  • Sijoon Lee1
  1. 1Preclinical Research Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, South Korea
  2. 2Biotoxtech Co. Ltd., Cheongju, South Korea.
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Abstract

Spontaneous lymphoid neoplasms are common among aged C57BL/6 mice, predominantly manifesting as T cell lymphomas. However, primary B cell lymphoblastic lymphomas are rare and poorly characterized, especially in laboratory animals. This case report describes a primary B cell lymphoblastic lymphoma in the spleen of a 24-month-old male C57BL/6 mouse. Gross examination revealed an enlarged spleen with a homogenous, white, firm mass replacing the normal parenchyma. Histopathological analysis revealed that the splenic architecture was diffusely replaced by neoplastic lymphoid cells with high mitotic activity. Immunohistochemical staining confirmed the B cell origin of the neoplasm, demonstrating strong CD20 positivity and CD3 negativity. This case underscores the importance of detailed pathological evaluation in aged laboratory mice, especially to distinguish spontaneous lesions from treatment-induced effects in experimental studies. These findings contribute to the understanding of lymphoid neoplasms in laboratory animals, as well as provide valuable reference data for pre-clinical research in toxicology and oncology.

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Cite

BibTeXRIS
BibTeX
@article{sung2026spontaneous,
  title = {{Spontaneous primary B cell lymphoblastic lymphoma of the spleen of a 24-month-old male C57BL/6 mouse}},
  author = {Soo-Eun Sung and Minkyoung Sung and Kyung-Ku Kang and Jae Woo Park and Ye-jin Kim and Sun Hee Park and Duyeol Kim and Sijoon Lee},
  journal = {Veterinary Research Forum},
  year = {2026},
  month = jul,
  doi = {10.30466/vrf.2025.2065919.4839},
  url = {https://doi.org/10.30466/vrf.2025.2065919.4839},
  note = {CC BY-NC-SA 4.0},
}
RIS
TY  - JOUR
TI  - Spontaneous primary B cell lymphoblastic lymphoma of the spleen of a 24-month-old male C57BL/6 mouse
AU  - Soo-Eun Sung
AU  - Minkyoung Sung
AU  - Kyung-Ku Kang
AU  - Jae Woo Park
AU  - Ye-jin Kim
AU  - Sun Hee Park
AU  - Duyeol Kim
AU  - Sijoon Lee
PY  - 2026
DA  - 2026/07/15
JO  - Veterinary Research Forum
DO  - 10.30466/vrf.2025.2065919.4839
UR  - https://doi.org/10.30466/vrf.2025.2065919.4839
AB  - Spontaneous lymphoid neoplasms are common among aged C57BL/6 mice, predominantly manifesting as T cell lymphomas. However, primary B cell lymphoblastic lymphomas are rare and poorly characterized, especially in laboratory animals. This case report describes a primary B cell lymphoblastic lymphoma in the spleen of a 24-month-old male C57BL/6 mouse. Gross examination revealed an enlarged spleen with a homogenous, white, firm mass replacing the normal parenchyma. Histopathological analysis revealed that the splenic architecture was diffusely replaced by neoplastic lymphoid cells with high mitotic activity. Immunohistochemical staining confirmed the B cell origin of the neoplasm, demonstrating strong CD20 positivity and CD3 negativity. This case underscores the importance of detailed pathological evaluation in aged laboratory mice, especially to distinguish spontaneous lesions from treatment-induced effects in experimental studies. These findings contribute to the understanding of lymphoid neoplasms in laboratory animals, as well as provide valuable reference data for pre-clinical research in toxicology and oncology.
SN  - 2008-8140
SN  - 2322-3618
ER  -