Embracing the Modern Biochemistry of Brain Metabolism
Abstract
This editorial challenges the long‐held neuron‐centered view of brain metabolism, relying on ample evidence that it is a cooperative, multicellular process. Astrocytes, oligodendrocytes, and other glia play active roles providing lactate, antioxidant support, and substrate shuttles that fuel neuronal function and memory. Despite mounting data, some critics persist in refuting intercellular metabolic exchange, often guided more by entrenched creeds than concrete evidence, slowing constructive, hypothesis‐driven discourse and delaying clinical and neuroprotective advances. The authors call for a rigorous research agenda: cell‐type‐specific manipulations, advanced biosensors, imaging and biomarkers, and integration with behavior and electrophysiology. They urge redirecting focus from outdated dogma to physiology‐driven exploration of glia–neuron metabolic partnerships. image
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BibTeX
@article{bolanos2026embracing,
title = {{Embracing the Modern Biochemistry of Brain Metabolism}},
author = {Juan P. Bolaños and Cristina Alberini and Angeles Almeida and L. Felipe Barros and Gilles Bonvento and Anne‐karine Bouzier-Sore and Ralf Dringen and Giles Hardingham and Johannes Hirrlinger and Pierre Magistretti and Giovanni Marsicano and Klaus-Armin Nave and Rosa Paolicelli and Luc Pellerin and Pierre-Yves Plaçais and Thomas Preat and Nathalie Rouach and Ivan Ruminot and Aiman Saab and Carmen Sandi and Stefanie Schirmeier and Avital Schurr and Jimena Sierralta and Maite Solas and Vanja Tepavčević and Bruno Weber and Eduardo R. Zimmer},
journal = {Journal of Neurochemistry},
year = {2026},
month = oct,
doi = {10.1111/jnc.70166},
url = {https://hal.science/hal-05359295v1},
note = {CC BY-NC-ND 4.0},
}
RIS
TY - JOUR
TI - Embracing the Modern Biochemistry of Brain Metabolism
AU - Juan P. Bolaños
AU - Cristina Alberini
AU - Angeles Almeida
AU - L. Felipe Barros
AU - Gilles Bonvento
AU - Anne‐karine Bouzier-Sore
AU - Ralf Dringen
AU - Giles Hardingham
AU - Johannes Hirrlinger
AU - Pierre Magistretti
AU - Giovanni Marsicano
AU - Klaus-Armin Nave
AU - Rosa Paolicelli
AU - Luc Pellerin
AU - Pierre-Yves Plaçais
AU - Thomas Preat
AU - Nathalie Rouach
AU - Ivan Ruminot
AU - Aiman Saab
AU - Carmen Sandi
AU - Stefanie Schirmeier
AU - Avital Schurr
AU - Jimena Sierralta
AU - Maite Solas
AU - Vanja Tepavčević
AU - Bruno Weber
AU - Eduardo R. Zimmer
PY - 2026
DA - 2026/10/12
JO - Journal of Neurochemistry
DO - 10.1111/jnc.70166
UR - https://hal.science/hal-05359295v1
AB - This editorial challenges the long‐held neuron‐centered view of brain metabolism, relying on ample evidence that it is a cooperative, multicellular process. Astrocytes, oligodendrocytes, and other glia play active roles providing lactate, antioxidant support, and substrate shuttles that fuel neuronal function and memory. Despite mounting data, some critics persist in refuting intercellular metabolic exchange, often guided more by entrenched creeds than concrete evidence, slowing constructive, hypothesis‐driven discourse and delaying clinical and neuroprotective advances. The authors call for a rigorous research agenda: cell‐type‐specific manipulations, advanced biosensors, imaging and biomarkers, and integration with behavior and electrophysiology. They urge redirecting focus from outdated dogma to physiology‐driven exploration of glia–neuron metabolic partnerships. image
SN - 0022-3042
SN - 1471-4159
ER -