Peer-reviewedCC BY-NC-ND 4.0Urology Case Reports
Osteoclast-like giant cell variant of bladder urothelial carcinoma with poor response to neoadjuvant chemotherapy managed by robot-assisted radical cystoprostatectomy: A case report
- 1Military Hospital Mohamed V of Rabat, 10100, Morocco
Abstract
The osteoclast-like giant cell (OGC) variant of urothelial carcinoma is a rare histological entity characterized by an aggressive clinical course and diagnostic challenges.
We report the case of a 62-year-old who presented with a muscle-invasive locally advanced urothelial carcinoma of the bladder. the tumor was resistant to chemotherapy. A completely robot-assisted radical cystoprostatectomy (RARC) with an intracorporeal Bricker ileal conduit urinary diversion was successfully performed. Histopathological evaluation of the surgical specimen demonstrated a OGC variant of bladder carcinoma.
This case highlights the potential chemoresistance of the OGC variant to conventional platinum-based neoadjuvant regimens.
Related
- Impact of neoadjuvant chemotherapy on the association between key genetic alterations and tumor microenvironment in upper tract urothelial carcinoma
- Expression of NECTIN-4 and TROP-2 in Resected Upper Tract Urothelial Carcinoma with and Without Preoperative Chemotherapy
- Pembrolizumab alone or combined with chemotherapy versus chemotherapy as first-line therapy for advanced urothelial carcinoma (KEYNOTE-361): a randomised, open-label, phase 3 trial
- Efficacy and safety of neoadjuvant chemotherapy with toripalimab in locally advanced nasopharyngeal carcinoma: a phase II trial and biological correlate analysis
- Bedside Bioimpedance and Simple Functional Tests Identify Muscle Function Impairment Predicting Overall Survival in Chemotherapy-treated Metastatic Urothelial Carcinoma: A Retrospective Pilot Study
BibTeX
@article{oukouhou2026osteoclastlike,
title = {{Osteoclast-like giant cell variant of bladder urothelial carcinoma with poor response to neoadjuvant chemotherapy managed by robot-assisted radical cystoprostatectomy: A case report}},
author = {Abdelhakim Oukouhou and Mohamed Tetou and Saad Assila and Abdessamad El Bahri and Mohamed Alami and Ahmed Ameur},
journal = {Urology Case Reports},
year = {2026},
month = oct,
doi = {10.1016/j.eucr.2026.103643},
url = {https://doi.org/10.1016/j.eucr.2026.103643},
note = {CC BY-NC-ND 4.0},
}
RIS
TY - JOUR
TI - Osteoclast-like giant cell variant of bladder urothelial carcinoma with poor response to neoadjuvant chemotherapy managed by robot-assisted radical cystoprostatectomy: A case report
AU - Abdelhakim Oukouhou
AU - Mohamed Tetou
AU - Saad Assila
AU - Abdessamad El Bahri
AU - Mohamed Alami
AU - Ahmed Ameur
PY - 2026
DA - 2026/10/12
JO - Urology Case Reports
DO - 10.1016/j.eucr.2026.103643
UR - https://doi.org/10.1016/j.eucr.2026.103643
AB - The osteoclast-like giant cell (OGC) variant of urothelial carcinoma is a rare histological entity characterized by an aggressive clinical course and diagnostic challenges. We report the case of a 62-year-old who presented with a muscle-invasive locally advanced urothelial carcinoma of the bladder. the tumor was resistant to chemotherapy. A completely robot-assisted radical cystoprostatectomy (RARC) with an intracorporeal Bricker ileal conduit urinary diversion was successfully performed. Histopathological evaluation of the surgical specimen demonstrated a OGC variant of bladder carcinoma. This case highlights the potential chemoresistance of the OGC variant to conventional platinum-based neoadjuvant regimens.
SN - 2214-4420
ER -