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Peer-reviewedCC BY-NC-NDAmerican journal of physiology. Cell physiology

Sexual dimorphisms in mechanisms of pressure natriuresis

  • Brandon E. McFarlin1
  • Donna L. Ralph1
  • Hermann Koepsell2
  • Anita T. Layton3
  • Alicia A. McDonough1
  1. 1Department of Physiology and Neuroscience, Keck School of Medicine of USC, Los Angeles, CA
  2. 2Institute for Anatomy and Cell Biology, University of Würzburg, Würzburg, Germany
  3. 3Departments of Applied Mathematics and Biology, Cheriton School of Computer Science, and School of Pharmacology, University of Waterloo, Waterloo, Ontario, Canada
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Abstract

Three discoveries contribute to understanding sex differences in blood pressure set-point: 1) females exhibit a greater natriuresis to acute hypertension (aHTN) than males; 2) aHTN provokes sex-specific molecular adaptations along the nephron: proximal NHE3 and NaPi2 redistribute in both sexes; medullary NHE3 and NKCC2 abundance are reduced in females, distal NCC abundance is reduced in males; 3) inhibition of arachidonic acid metabolites shifts renal function curves leftward in both sexes, and augments natriuresis in males.

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Cite

BibTeXRIS
BibTeX
@article{mcfarlin2026sexual,
  title = {{Sexual dimorphisms in mechanisms of pressure natriuresis}},
  author = {Brandon E. McFarlin and Donna L. Ralph and Hermann Koepsell and Anita T. Layton and Alicia A. McDonough},
  journal = {American journal of physiology. Cell physiology},
  year = {2026},
  month = aug,
  doi = {10.1152/ajpcell.00385.2026},
  url = {https://doi.org/10.1152/ajpcell.00385.2026},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Sexual dimorphisms in mechanisms of pressure natriuresis
AU  - Brandon E. McFarlin
AU  - Donna L. Ralph
AU  - Hermann Koepsell
AU  - Anita T. Layton
AU  - Alicia A. McDonough
PY  - 2026
DA  - 2026/08/24
JO  - American journal of physiology. Cell physiology
DO  - 10.1152/ajpcell.00385.2026
UR  - https://doi.org/10.1152/ajpcell.00385.2026
AB  - Three discoveries contribute to understanding sex differences in blood pressure set-point: 1) females exhibit a greater natriuresis to acute hypertension (aHTN) than males; 2) aHTN provokes sex-specific molecular adaptations along the nephron: proximal NHE3 and NaPi2 redistribute in both sexes; medullary NHE3 and NKCC2 abundance are reduced in females, distal NCC abundance is reduced in males; 3) inhibition of arachidonic acid metabolites shifts renal function curves leftward in both sexes, and augments natriuresis in males.
SN  - 0363-6143
SN  - 1522-1563
ER  -