Multifunctional Nanoplatforms for Endoplasmic Reticulum-Targeted Cancer Therapy
Abstract
Innovations in therapeutic modalities and targeted drug delivery are two key approaches for improving the effectiveness of cancer treatment. With the development of therapeutic concepts and nanotechnology, recent research has shifted from tissue-or cell-level drug delivery toward organelle-specific delivery to amplify therapeutic effects. Among these organelles, the endoplasmic reticulum (ER) has emerged as a particularly promising target due to its extensive membrane network, which serves as a major site for protein synthesis, lipid metabolism, calcium homeostasis, and intracellular signaling. The disruption of ER function can trigger severe cellular stress and apoptosis, providing a rationale for ER-targeted cancer therapy. However, traditional small-molecule drugs often exhibit poor ER specificity, rapid degradation, and limited intracellular accumulation, significantly restricting their therapeutic potential. In contrast, ERtargeting multifunctional nanoplatforms have demonstrated superior advantages, including enhanced stability, precise localization, controlled drug release, and multimodal therapeutic capabilities. In this review, we systematically summarize the recent advances in ER-targeting nanotherapeutics and their applications in chemotherapy, phototherapy, immunotherapy, biotherapy, and combination therapy. Furthermore, we discuss the advantages, challenges, and mechanistic insights of these strategies, aiming to provide perspectives for accelerating the clinical translation of ER-targeting precision drugs.
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BibTeX
@article{you2026multifunctional,
title = {{Multifunctional Nanoplatforms for Endoplasmic Reticulum-Targeted Cancer Therapy}},
author = {Zhu You and Jing Du and Tianqi Zhang and Mingyang Liu and Tengda Zhao and Changwei Yin and Alberto Bianco and Baojin Ma and Shizhou Zhang},
journal = {ACS Nano},
year = {2026},
month = jul,
doi = {10.1021/acsnano.6c08721},
url = {https://hal.science/hal-05770604v1},
note = {CC BY-NC-ND 4.0},
}
RIS
TY - JOUR
TI - Multifunctional Nanoplatforms for Endoplasmic Reticulum-Targeted Cancer Therapy
AU - Zhu You
AU - Jing Du
AU - Tianqi Zhang
AU - Mingyang Liu
AU - Tengda Zhao
AU - Changwei Yin
AU - Alberto Bianco
AU - Baojin Ma
AU - Shizhou Zhang
PY - 2026
DA - 2026/07/29
JO - ACS Nano
DO - 10.1021/acsnano.6c08721
UR - https://hal.science/hal-05770604v1
AB - Innovations in therapeutic modalities and targeted drug delivery are two key approaches for improving the effectiveness of cancer treatment. With the development of therapeutic concepts and nanotechnology, recent research has shifted from tissue-or cell-level drug delivery toward organelle-specific delivery to amplify therapeutic effects. Among these organelles, the endoplasmic reticulum (ER) has emerged as a particularly promising target due to its extensive membrane network, which serves as a major site for protein synthesis, lipid metabolism, calcium homeostasis, and intracellular signaling. The disruption of ER function can trigger severe cellular stress and apoptosis, providing a rationale for ER-targeted cancer therapy. However, traditional small-molecule drugs often exhibit poor ER specificity, rapid degradation, and limited intracellular accumulation, significantly restricting their therapeutic potential. In contrast, ERtargeting multifunctional nanoplatforms have demonstrated superior advantages, including enhanced stability, precise localization, controlled drug release, and multimodal therapeutic capabilities. In this review, we systematically summarize the recent advances in ER-targeting nanotherapeutics and their applications in chemotherapy, phototherapy, immunotherapy, biotherapy, and combination therapy. Furthermore, we discuss the advantages, challenges, and mechanistic insights of these strategies, aiming to provide perspectives for accelerating the clinical translation of ER-targeting precision drugs.
SN - 1936-0851
SN - 1936-086X
ER -