Intraductal papillary neoplasm of cystic duct with associated invasive carcinoma: A rare cause of acute cholecystitis
Abstract
Intraductal papillary neoplasm of the bile ducts (IPNB) is a premalignant epithelial lesion of the biliary tract. IPNB arising from the cystic duct is extremely rare. A man in his 70s presented with right upper quadrant abdominal pain with radiation to the right shoulder. Imaging studies revealed a small enhancing lesion in the gallbladder cystic duct, accompanied by features of acute cholecystitis. Macroscopic evaluation of the cholecystectomy specimen showed an intraluminal papillary lesion confined to the cystic duct. Histologic examination demonstrated intraductal papillary proliferation with high-grade dysplasia and focal invasion, consistent with IPNB with invasive carcinoma (pT1b). This case highlights the rare presentation of cystic duct IPNB with luminal obstruction and acute cholecystitis.
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BibTeX
@article{soleimani2026intraductal,
title = {{Intraductal papillary neoplasm of cystic duct with associated invasive carcinoma: A rare cause of acute cholecystitis}},
author = {Neda Soleimani MD and Mohammad Hossein Anbardar MD and Sahar Asadi MD and Soudabeh Khoshniat MD and Mohammad Hadi Niakan MD and Hossein Afrakhteh MD},
journal = {Rare Tumors},
year = {2026},
month = nov,
doi = {10.1177/20363613261508157},
url = {https://doi.org/10.1177/20363613261508157},
note = {CC BY},
}
RIS
TY - JOUR
TI - Intraductal papillary neoplasm of cystic duct with associated invasive carcinoma: A rare cause of acute cholecystitis
AU - Neda Soleimani MD
AU - Mohammad Hossein Anbardar MD
AU - Sahar Asadi MD
AU - Soudabeh Khoshniat MD
AU - Mohammad Hadi Niakan MD
AU - Hossein Afrakhteh MD
PY - 2026
DA - 2026/11/13
JO - Rare Tumors
DO - 10.1177/20363613261508157
UR - https://doi.org/10.1177/20363613261508157
AB - Intraductal papillary neoplasm of the bile ducts (IPNB) is a premalignant epithelial lesion of the biliary tract. IPNB arising from the cystic duct is extremely rare. A man in his 70s presented with right upper quadrant abdominal pain with radiation to the right shoulder. Imaging studies revealed a small enhancing lesion in the gallbladder cystic duct, accompanied by features of acute cholecystitis. Macroscopic evaluation of the cholecystectomy specimen showed an intraluminal papillary lesion confined to the cystic duct. Histologic examination demonstrated intraductal papillary proliferation with high-grade dysplasia and focal invasion, consistent with IPNB with invasive carcinoma (pT1b). This case highlights the rare presentation of cystic duct IPNB with luminal obstruction and acute cholecystitis.
SN - 2036-3613
SN - 2036-3605
ER -