Association between intrinsic capacity transitions and the risk of diabetes in middle-aged and older adults
- 1The First Affiliated Hospital of Jinan University, Guangdong, 510630 China
- 2Jinan University, Guangdong, 510632 China
Abstract
Objective: Intrinsic capacity (IC) is a person-centered comprehensive assessment framework that focuses on optimizing individuals’ functional ability and resilience to environmental challenges, defined as the sum of all physical and mental capacities of an individual. Based on cohort data from the CHARLS, this study investigated the associations of baseline IC and its dynamic transition patterns with the risk of incident diabetes in middle-aged and older adults, aiming to provide evidence for precise diabetes prevention and control.
Methods: Five waves of CHARLS data (2011–2020) were included, with 2011 as the baseline. IC transition patterns were assessed using 2011–2013 data, and participants were followed up to 2020 for incident diabetes. Cox proportional hazards regression was performed to evaluate these associations.
Results: 15.6% of participants developed diabetes. Compared with the low IC group, moderate and high IC groups had an 18.8% and 26.7% lower risk of diabetes, respectively. Four IC patterns were identified: Improved IC, Stable IC Impairment, Declined IC, and Stable Non-IC Impairment. Compared with Stable Non-IC Impairment, the Improved IC (HR 1.272, 95% CI: 1.019,1.588) and Stable IC Impairment (HR 1.474, 95% CI: 1.167,1.863) groups had significantly higher risks, whereas the Declined IC group showed no significant association.
Conclusion: Baseline IC and its dynamic transition patterns are differentially associated with diabetes risk in middle-aged and older adults. IC should be integrated into diabetes prevention and control systems, with dynamic monitoring and individualized interventions to reduce disease risk.
Supplementary Information: The online version contains supplementary material available at https://doi.org/10.1007/s40520-026-03466-5.
Related
- Association of dietary total antioxidant capacity, dietary inflammatory index, and dietary phytochemical index with sarcopenia in middle-aged and older Iranian women: a case-control study
- Intrinsic capacity patterns and their association with early postoperative functional outcomes in older adults undergoing total knee arthroplasty
- Association Between Dietary Diversity and Intrinsic Capacity Among Chinese Older Adults: A Cross-Sectional Study Based on the CLHLS 2018
- Latent class analysis of intrinsic capacity and its association with quality of life in hospitalized older people with stroke: a cross-sectional study
- Nonlinear association of cholesterol, high-density lipoprotein, and glucose index with the risk of prediabetes and diabetes in normal-weight middle-aged and older Chinese adults: a multicenter retrospective cohort study
BibTeX
@article{lin2026association,
title = {{Association between intrinsic capacity transitions and the risk of diabetes in middle-aged and older adults}},
author = {Xiaoling Lin and Shiyang Zhang and Wenhui Zhu and Jiewei Huang and Xianghua Yuan},
journal = {Aging Clinical and Experimental Research},
year = {2026},
month = aug,
doi = {10.1007/s40520-026-03466-5},
url = {https://doi.org/10.1007/s40520-026-03466-5},
note = {CC BY-NC-ND 4.0},
}
RIS
TY - JOUR
TI - Association between intrinsic capacity transitions and the risk of diabetes in middle-aged and older adults
AU - Xiaoling Lin
AU - Shiyang Zhang
AU - Wenhui Zhu
AU - Jiewei Huang
AU - Xianghua Yuan
PY - 2026
DA - 2026/08/05
JO - Aging Clinical and Experimental Research
DO - 10.1007/s40520-026-03466-5
UR - https://doi.org/10.1007/s40520-026-03466-5
AB - Objective: Intrinsic capacity (IC) is a person-centered comprehensive assessment framework that focuses on optimizing individuals’ functional ability and resilience to environmental challenges, defined as the sum of all physical and mental capacities of an individual. Based on cohort data from the CHARLS, this study investigated the associations of baseline IC and its dynamic transition patterns with the risk of incident diabetes in middle-aged and older adults, aiming to provide evidence for precise diabetes prevention and control. Methods: Five waves of CHARLS data (2011–2020) were included, with 2011 as the baseline. IC transition patterns were assessed using 2011–2013 data, and participants were followed up to 2020 for incident diabetes. Cox proportional hazards regression was performed to evaluate these associations. Results: 15.6% of participants developed diabetes. Compared with the low IC group, moderate and high IC groups had an 18.8% and 26.7% lower risk of diabetes, respectively. Four IC patterns were identified: Improved IC, Stable IC Impairment, Declined IC, and Stable Non-IC Impairment. Compared with Stable Non-IC Impairment, the Improved IC (HR 1.272, 95% CI: 1.019,1.588) and Stable IC Impairment (HR 1.474, 95% CI: 1.167,1.863) groups had significantly higher risks, whereas the Declined IC group showed no significant association. Conclusion: Baseline IC and its dynamic transition patterns are differentially associated with diabetes risk in middle-aged and older adults. IC should be integrated into diabetes prevention and control systems, with dynamic monitoring and individualized interventions to reduce disease risk. Supplementary Information: The online version contains supplementary material available at https://doi.org/10.1007/s40520-026-03466-5.
SN - 1594-0667
SN - 1720-8319
ER -