Body Mass Index, Cardiometabolic Treatment Patterns and Multifactorial Risk‐Factor Control in Chinese Adults With Type 2 Diabetes: A Multicenter Cross‐Sectional Study
8 affiliations
- 1Department of Endocrinology Peking University People's Hospital Beijing China
- 2Beijing Key Laboratory of Innovative Drug and Device Translation in Endocrine and Metabolic Diseases Beijing China
- 3Department of Endocrinology and Metabolism Tianjin Medical University General Hospital Tianjin China
- 4Department of Endocrinology and Diabetes Center The First Affiliated Hospital of Sun Yat‐Sen University Guangzhou China
- 5Department of Endocrinology Xi'an International Medical Center Hospital Xi'an China
- 6Department of Endocrinology Shanghai East Hospital, Tongji University Shanghai China
- 7Department of Endocrinology and Metabolism West China Hospital, Sichuan University Chengdu China
- 8Peking University Diabetes Center Beijing China
Abstract
Background: To examine medication use and simultaneous achievement of glycemic, blood pressure and lipid targets across body mass index (BMI) categories in Chinese adults with Type 2 diabetes.
Methods: This BMI‐focused secondary cross‐sectional analysis included 8590 adults with evaluable BMI recruited from 60 hospitals in the iCaReMe China Registry. The primary comparison was obesity versus normal weight for simultaneous achievement of HbA1c < 7.0%, blood pressure < 130/80 mmHg and LDL cholesterol < 2.6 mmol/L. Missing data were handled by multiple imputation (20 datasets; 20 iterations per chain), and associations were estimated with center‐clustered generalized estimating equations (GEE).
Results: The cohort comprised 99 (1.2%) adults with underweight, 2725 (31.7%) normal weight, 3663 (42.6%) overweight, and 2103 (24.5%) obesity. Among 6683 with all three observed components, 332 (5.0%) achieved the composite. Compared with normal weight, the pooled adjusted OR for obesity was 0.55 (95% CI 0.39–0.78); each 1‐kg/m2 higher BMI was associated with an OR of 0.93 (0.90–0.96). For obesity, component‐specific ORs were 0.72 (0.61–0.85) for HbA1c, 0.47 (0.40–0.55) for blood pressure and 1.05 (0.91–1.22) for LDL‐C. Sensitivity analyses supported the composite finding, with no evidence of nonlinearity (p = 0.904).
Conclusions: Obesity was associated with lower odds of simultaneous target attainment, with component‐specific associations for glycemia and blood pressure but not LDL‐C. GLP‐1 receptor agonists and SGLT2 inhibitors were used more often at higher BMI; these prescribing patterns do not establish treatment effectiveness.
Trial Registration: ChiCTR2300073764.
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BibTeX
@article{yan2026body,
title = {{Body Mass Index, Cardiometabolic Treatment Patterns and Multifactorial Risk‐Factor Control in Chinese Adults With Type 2 Diabetes: A Multicenter Cross‐Sectional Study}},
author = {Jingya Yan and Wenjia Yang and Xiaoling Cai and Ming Liu and Yanbing Li and Qiuhe Ji and Bo Feng and Nanwei Tong and Linong Ji},
journal = {Journal of Diabetes},
year = {2026},
month = nov,
doi = {10.1111/1753-0407.70296},
url = {https://doi.org/10.1111/1753-0407.70296},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Body Mass Index, Cardiometabolic Treatment Patterns and Multifactorial Risk‐Factor Control in Chinese Adults With Type 2 Diabetes: A Multicenter Cross‐Sectional Study
AU - Jingya Yan
AU - Wenjia Yang
AU - Xiaoling Cai
AU - Ming Liu
AU - Yanbing Li
AU - Qiuhe Ji
AU - Bo Feng
AU - Nanwei Tong
AU - Linong Ji
PY - 2026
DA - 2026/11/03
JO - Journal of Diabetes
DO - 10.1111/1753-0407.70296
UR - https://doi.org/10.1111/1753-0407.70296
AB - Background: To examine medication use and simultaneous achievement of glycemic, blood pressure and lipid targets across body mass index (BMI) categories in Chinese adults with Type 2 diabetes. Methods: This BMI‐focused secondary cross‐sectional analysis included 8590 adults with evaluable BMI recruited from 60 hospitals in the iCaReMe China Registry. The primary comparison was obesity versus normal weight for simultaneous achievement of HbA1c < 7.0%, blood pressure < 130/80 mmHg and LDL cholesterol < 2.6 mmol/L. Missing data were handled by multiple imputation (20 datasets; 20 iterations per chain), and associations were estimated with center‐clustered generalized estimating equations (GEE). Results: The cohort comprised 99 (1.2%) adults with underweight, 2725 (31.7%) normal weight, 3663 (42.6%) overweight, and 2103 (24.5%) obesity. Among 6683 with all three observed components, 332 (5.0%) achieved the composite. Compared with normal weight, the pooled adjusted OR for obesity was 0.55 (95% CI 0.39–0.78); each 1‐kg/m2 higher BMI was associated with an OR of 0.93 (0.90–0.96). For obesity, component‐specific ORs were 0.72 (0.61–0.85) for HbA1c, 0.47 (0.40–0.55) for blood pressure and 1.05 (0.91–1.22) for LDL‐C. Sensitivity analyses supported the composite finding, with no evidence of nonlinearity (p = 0.904). Conclusions: Obesity was associated with lower odds of simultaneous target attainment, with component‐specific associations for glycemia and blood pressure but not LDL‐C. GLP‐1 receptor agonists and SGLT2 inhibitors were used more often at higher BMI; these prescribing patterns do not establish treatment effectiveness. Trial Registration: ChiCTR2300073764.
SN - 1753-0393
SN - 1753-0407
ER -