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Peer-reviewedCC BYAdvances in Cancer Biology - Metastasis

Circulating tumor cells atlas – an open-access platform capturing tumor cells heterogeneity during cancer dissemination

  • Anna Muchlińska1
  • Julia Richert1
  • Robert Wenta1
  • Aleksandra Parteka1
  • Marta Popęda2
  • Beata Pieczyńska-Uziębło1
  • Anna Żaczek1
  • Natalia Bednarz-Knoll3
  1. 1Laboratory of Translational Oncology, Intercollegiate Faculty of Biotechnology, Medical University of Gdańsk, Gdańsk, 80-210, Poland
  2. 2Department of Pathomorphology, Medical University of Gdańsk, Gdańsk, 80-210, Poland
  3. 3Laboratory of Translational Oncology, Intercollegiate Faculty of Biotechnology, Medical University of Gdańsk, Gdańsk, 80-210, Poland; Corresponding author. Laboratory of Translational Oncology, Intercollegiate Faculty of Biotechnology, Medical University of Gdańsk, ul. Dębinki 1, 80-210, Gdańsk, Poland.
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Abstract

Circulating tumor cells (CTCs) are key cellular intermediates in the metastatic cascade and provide a minimally invasive window into tumor heterogeneity and evolution during metastatic progression. Despite this potential, the broader clinical and research utility of CTC-based liquid biopsy remains limited by the lack of standardized, image-based reference resources. We introduce CTC Atlas ( www.CTCAtlas.org ), an open-access platform integrating high-resolution images of diverse CTCs and other circulating tumor-associated cells with technical, clinical, and multi-omics data. CTC Atlas aims to support CTC identification, cross-laboratory comparisons, and clinical implementation of variable CTC-based assays. It also provides a reference framework for studying phenotypic heterogeneity during tumor dissemination, and matched circulating microenvironment associated with metastatic progression.

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Cite

BibTeXRIS
BibTeX
@article{muchlinska2026circulating,
  title = {{Circulating tumor cells atlas – an open-access platform capturing tumor cells heterogeneity during cancer dissemination}},
  author = {Anna Muchlińska and Julia Richert and Robert Wenta and Aleksandra Parteka and Marta Popęda and Beata Pieczyńska-Uziębło and Anna Żaczek and Natalia Bednarz-Knoll},
  journal = {Advances in Cancer Biology - Metastasis},
  year = {2026},
  month = oct,
  doi = {10.1016/j.adcanc.2026.100221},
  url = {https://doi.org/10.1016/j.adcanc.2026.100221},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Circulating tumor cells atlas – an open-access platform capturing tumor cells heterogeneity during cancer dissemination
AU  - Anna Muchlińska
AU  - Julia Richert
AU  - Robert Wenta
AU  - Aleksandra Parteka
AU  - Marta Popęda
AU  - Beata Pieczyńska-Uziębło
AU  - Anna Żaczek
AU  - Natalia Bednarz-Knoll
PY  - 2026
DA  - 2026/10/30
JO  - Advances in Cancer Biology - Metastasis
DO  - 10.1016/j.adcanc.2026.100221
UR  - https://doi.org/10.1016/j.adcanc.2026.100221
AB  - Circulating tumor cells (CTCs) are key cellular intermediates in the metastatic cascade and provide a minimally invasive window into tumor heterogeneity and evolution during metastatic progression. Despite this potential, the broader clinical and research utility of CTC-based liquid biopsy remains limited by the lack of standardized, image-based reference resources. We introduce CTC Atlas ( www.CTCAtlas.org ), an open-access platform integrating high-resolution images of diverse CTCs and other circulating tumor-associated cells with technical, clinical, and multi-omics data. CTC Atlas aims to support CTC identification, cross-laboratory comparisons, and clinical implementation of variable CTC-based assays. It also provides a reference framework for studying phenotypic heterogeneity during tumor dissemination, and matched circulating microenvironment associated with metastatic progression.
SN  - 2667-3940
ER  -