Skip to content
DraconiticResearch
Search Sources API
197,768 studies31 sourcesUpdated 41 min ago
Peer-reviewedCC BY-NC-ND 4.0Thrombosis Journal

Risk factors for venous thromboembolic events at 90 days in hospitalized patients with advanced cancer receiving palliative care: a multicenter retrospective cohort study

  • María Camila Luna-Benitez1
  • Johana Benavides‑Cruz2
  • Diana Catalina Borda-Restrepo1,3
  • Juan Felipe Combariza4,5
  • Marcela Andrea Erazo-Muñoz6
  • Mario Fernando Escobar-Olaya5,7
  • Luisa Fernanda Patiño-Unibio5,7
7 affiliations
  1. 1Programa Medicina del dolor y Cuidados Paliativos, Fundación Universitaria Sanitas, Bogotá, Colombia
  2. 2Unidad de Investigación, Fundación Universitaria Sanitas, Bogotá, Colombia
  3. 3Programa Contigo de Cuidados Paliativos, Clínica Universitaria Colombia, Bogotá, Colombia
  4. 4Servicio de Hematología y Trasplante de Médula Ósea, Clínica Universitaria Colombia, Bogotá, Colombia
  5. 5Programa Medicina Interna, Fundación Universitaria Sanitas, Bogotá, Colombia
  6. 6Unidad para el Alivio de dolor y Cuidados Paliativos, Clínica Reina Sofía, Bogotá, Colombia
  7. 7Servicio de Medicina Interna, Clínica Universitaria Colombia, Bogotá, Colombia
Read full textPDFDOICite

Abstract

Purpose: Evidence regarding venous thromboembolism (VTE) risk in palliative care populations remains scarce, and current thromboprophylaxis recommendations are largely extrapolated from non-palliative oncology cohorts. This study aimed to determine the 90-day incidence of VTE and associated clinical risk factors in hospitalized patients with advanced cancer receiving palliative care.

Methods: This multicenter retrospective cohort study included adults with advanced cancer enrolled in a palliative care program who were hospitalized between 2018 and 2024 at two tertiary care centers in Bogotá, Colombia. VTE incidence was calculated, and clinical risk factors were identified using multivariable Cox proportional hazards models.

Results: A total of 782 patients were included (mean age 61 years; 58.7% male). Withing 90 days of admission, 81 patients (10.3%) developed VTE, corresponding to an incidence density of 2.3 events per 1,000 patient-days. Pulmonary embolism accounted for 40.7% of VTE events. In the adjusted analysis, lung cancer was associated with an increased risk of VTE (HR 2.34; p = 0.010), whereas higher Karnofsky Performance Status was associated with a lower risk (HR 0.98; p = 0.020). Age, sex, body mass index, baseline hemoglobin, active anticancer treatment, and white blood cell count were not independently associated with VTE. Overall, 90-day mortality was 66.3%.

Conclusion: VTE was a frequent complication among hospitalized patients with advanced cancer receiving palliative care. Lung cancer and poor functional status were independently associated with VTE, whereas traditional clinical predictors were not associated with VTE. These findings support individualized VTE risk assessment and highlight the need for future prospective studies evaluating thromboprophylaxis strategies in palliative care settings.

Related

  1. Lymph Node Regression Improves Prognostic Stratification in Esophageal Squamous Cell Carcinoma Receiving Neoadjuvant Chemoimmunotherapy: A Multicenter Retrospective Cohort Study.
    Jian Zheng, Wenbin Shen, Jianzhong Cao +13
    MedCommPeer-reviewedCC BYFull textSurgery & anaesthesiaEurope PMC
  2. CO037 | PERFORMANCE OF A QUALITATIVE POINT-OF-CARE TEST IN PATIENTS EXPERIENCING ACUTE THROMBOEMBOLIC OR MAJOR BLEEDING EVENTS TREATED WITH DOACs: THE T-BLEEDOAC MULTICENTER PROSPECTIVE COHORT STUDY
    Maria Cristina Vedovati
    Bleeding, Thrombosis and Vascular BiologyPeer-reviewedCC BY-NCFull textCardiovascular medicineDOAJ
  3. Family history of postpartum hemorrhage is a risk factor for postpartum hemorrhage after vaginal delivery: results from the French prospective multicenter Haemorrhages and Thromboembolic Venous Disease of the Postpartum cohort study
    François Anouilh, Claire de Moreuil, Christophe Trémouilhac +19
    American Journal of Obstetrics & Gynecology MFMPeer-reviewedCC BY-NC-ND 4.0Full text14 citedGeneral biologyEpidemiology & public healthHAL
  4. Prognostic value of modified thrombelastometry for thromboembolic risk stratification in neurosurgical patients: protocol for a prospective, multicenter, observational study (TENS).
    Hi-Jae Heiroth, Philipp Groene, Simon Schäfer +14
    Diagnostic and prognostic researchPeer-reviewedCC BYFull textGeneral medicineEurope PMCPMC
  5. Prognostic Impact of Overhydration in Hospitalized Patients Receiving Parenteral Nutrition
    Alba Zabalegui-Eguinoa, Fernanda Mucarzel-Suarez-Arana, Raül Cartiel-Vesperinas +7
    NutrientsPeer-reviewedCC BY 4.0NutritionCrossref

Cite

BibTeXRIS
BibTeX
@article{lunabenitez2026risk,
  title = {{Risk factors for venous thromboembolic events at 90 days in hospitalized patients with advanced cancer receiving palliative care: a multicenter retrospective cohort study}},
  author = {María Camila Luna-Benitez and Johana Benavides‑Cruz and Diana Catalina Borda-Restrepo and Juan Felipe Combariza and Marcela Andrea Erazo-Muñoz and Mario Fernando Escobar-Olaya and Luisa Fernanda Patiño-Unibio},
  journal = {Thrombosis Journal},
  year = {2026},
  month = oct,
  doi = {10.1186/s12959-026-00910-4},
  url = {https://doi.org/10.1186/s12959-026-00910-4},
  note = {CC BY-NC-ND 4.0},
}
RIS
TY  - JOUR
TI  - Risk factors for venous thromboembolic events at 90 days in hospitalized patients with advanced cancer receiving palliative care: a multicenter retrospective cohort study
AU  - María Camila Luna-Benitez
AU  - Johana Benavides‑Cruz
AU  - Diana Catalina Borda-Restrepo
AU  - Juan Felipe Combariza
AU  - Marcela Andrea Erazo-Muñoz
AU  - Mario Fernando Escobar-Olaya
AU  - Luisa Fernanda Patiño-Unibio
PY  - 2026
DA  - 2026/10/27
JO  - Thrombosis Journal
DO  - 10.1186/s12959-026-00910-4
UR  - https://doi.org/10.1186/s12959-026-00910-4
AB  - Purpose: Evidence regarding venous thromboembolism (VTE) risk in palliative care populations remains scarce, and current thromboprophylaxis recommendations are largely extrapolated from non-palliative oncology cohorts. This study aimed to determine the 90-day incidence of VTE and associated clinical risk factors in hospitalized patients with advanced cancer receiving palliative care.  Methods: This multicenter retrospective cohort study included adults with advanced cancer enrolled in a palliative care program who were hospitalized between 2018 and 2024 at two tertiary care centers in Bogotá, Colombia. VTE incidence was calculated, and clinical risk factors were identified using multivariable Cox proportional hazards models.  Results: A total of 782 patients were included (mean age 61 years; 58.7% male). Withing 90 days of admission, 81 patients (10.3%) developed VTE, corresponding to an incidence density of 2.3 events per 1,000 patient-days. Pulmonary embolism accounted for 40.7% of VTE events. In the adjusted analysis, lung cancer was associated with an increased risk of VTE (HR 2.34; p = 0.010), whereas higher Karnofsky Performance Status was associated with a lower risk (HR 0.98; p = 0.020). Age, sex, body mass index, baseline hemoglobin, active anticancer treatment, and white blood cell count were not independently associated with VTE. Overall, 90-day mortality was 66.3%.  Conclusion: VTE was a frequent complication among hospitalized patients with advanced cancer receiving palliative care. Lung cancer and poor functional status were independently associated with VTE, whereas traditional clinical predictors were not associated with VTE. These findings support individualized VTE risk assessment and highlight the need for future prospective studies evaluating thromboprophylaxis strategies in palliative care settings.
SN  - 1477-9560
ER  -