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Peer-reviewedCC BYPLOS One

Phytochemical analyses, antimicrobial, antioxidant and anticancer activities of endophytic fungi from leaves of Reseda pruinosa

  • Amr H Hashem1
  • Nosiba S Basher2
  • Abeer S Aloufi3
  • Salem S Salem1
  • Mahmoud M Fawzi4
  • Mohamed M Abdelaziz4
  • Ahmed S Abdelrahman4
  • Mohamed S Khader4
  • Abdallah E Emam4
  • Mohamed A Goma4
  • Ahmed R Salama4
  • Nasir A Ibrahim2
3 more authors
  • Sulaiman A Alsalamah2
  • Fahd A Nasr2
  • Amer M Abdelaziz1
4 affiliations
  1. 1Botany and Microbiology Department, Faculty of Science, Al-Azhar University, Cairo, Egypt.
  2. 2Biology Department, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia.
  3. 3Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.
  4. 4Faculty of Science, Al-Azhar University, Cairo, Egypt.
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Abstract

Fungal endophytes considered one of the major sources of promising bioactive compounds. This study aimed to isolate endophytic fungi from leaves of Reseda pruinosa for the first time, and to evaluate their biological activities. Results illustrated that, two fungal endophytes isolates were isolated, identified as Alternaria sp. and Alternaria alternata morphologically and genetically. Phytochemical analyses of these two fungal isolates metabolites showed significant amounts of phenolics, flavonoids, tannins, and alkaloids. GC-MS analyses of the crude extracts of these two fungal isolates showed that, major compounds in these extracts belong to the classes of fatty acid esters, fatty acids, and terpenoids. Results revealed that the MCF-7 cancer cells was susceptible to the anticancer effects of both fungal isolates crude extracts, with IC50 values of 96.3 and 117.4 µg/ml, respectively. Additionally, it showed promising antibacterial efficacy against pathogenic bacteria and fungi. Moreover, both crude extracts of fungal isolates exhibited antioxidant activity, with EC50 values of 234.8 µg/ml and 133.4 µg/ml respectively. Endophytic Alternaria species from leaves of R. pruinosa are a novel source for bioactive compounds that used in different medical fields.

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Cite

BibTeXRIS
BibTeX
@article{hashem2026phytochemical,
  title = {{Phytochemical analyses, antimicrobial, antioxidant and anticancer activities of endophytic fungi from leaves of Reseda pruinosa}},
  author = {Amr H Hashem and Nosiba S Basher and Abeer S Aloufi and Salem S Salem and Mahmoud M Fawzi and Mohamed M Abdelaziz and Ahmed S Abdelrahman and Mohamed S Khader and Abdallah E Emam and Mohamed A Goma and Ahmed R Salama and Nasir A Ibrahim and Sulaiman A Alsalamah and Fahd A Nasr and Amer M Abdelaziz},
  journal = {PLOS One},
  year = {2026},
  month = oct,
  doi = {10.1371/journal.pone.0357606},
  url = {https://doi.org/10.1371/journal.pone.0357606},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Phytochemical analyses, antimicrobial, antioxidant and anticancer activities of endophytic fungi from leaves of Reseda pruinosa
AU  - Amr H Hashem
AU  - Nosiba S Basher
AU  - Abeer S Aloufi
AU  - Salem S Salem
AU  - Mahmoud M Fawzi
AU  - Mohamed M Abdelaziz
AU  - Ahmed S Abdelrahman
AU  - Mohamed S Khader
AU  - Abdallah E Emam
AU  - Mohamed A Goma
AU  - Ahmed R Salama
AU  - Nasir A Ibrahim
AU  - Sulaiman A Alsalamah
AU  - Fahd A Nasr
AU  - Amer M Abdelaziz
PY  - 2026
DA  - 2026/10/29
JO  - PLOS One
DO  - 10.1371/journal.pone.0357606
UR  - https://doi.org/10.1371/journal.pone.0357606
AB  - Fungal endophytes considered one of the major sources of promising bioactive compounds. This study aimed to isolate endophytic fungi from leaves of Reseda pruinosa for the first time, and to evaluate their biological activities. Results illustrated that, two fungal endophytes isolates were isolated, identified as Alternaria sp. and Alternaria alternata morphologically and genetically. Phytochemical analyses of these two fungal isolates metabolites showed significant amounts of phenolics, flavonoids, tannins, and alkaloids. GC-MS analyses of the crude extracts of these two fungal isolates showed that, major compounds in these extracts belong to the classes of fatty acid esters, fatty acids, and terpenoids. Results revealed that the MCF-7 cancer cells was susceptible to the anticancer effects of both fungal isolates crude extracts, with IC50 values of 96.3 and 117.4 µg/ml, respectively. Additionally, it showed promising antibacterial efficacy against pathogenic bacteria and fungi. Moreover, both crude extracts of fungal isolates exhibited antioxidant activity, with EC50 values of 234.8 µg/ml and 133.4 µg/ml respectively. Endophytic Alternaria species from leaves of R. pruinosa are a novel source for bioactive compounds that used in different medical fields.
SN  - 1932-6203
ER  -