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Peer-reviewedCC BY 4.0BioTechnologia

Oligoglycine-functionalized gold nanoparticles: physicochemical characterisation and serum protein interactions

  • Ivailo S. Atanasov1
  • Svetla Todinova2
  • Eduarda Encheva3
  • Plamen Tchoukov3,4
  • Velichka Strijkova5
  • Nadya Stankova6
  • Anna Dikovska6
  • Lidia Gartcheva7
  • Borislava Antonova1
7 affiliations
  1. 1Medical Faculty, Medical University, Sofia, Bulgaria
  2. 2Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, Bulgaria
  3. 3Institute of Physical Chemistry, Bulgarian Academy of Sciences, Bulgaria
  4. 4National Centre of Excellence Mechatronics and Clean Technologies, Sofia, Bulgaria
  5. 5Institute of Optical Materials and Technologies, Bulgarian Academy of Sciences, Bulgaria
  6. 6Institute of Electronics, Bulgarian Academy of Sciences, Bulgaria
  7. 7National Specialized Hospital for Active Treatment of Hematological Diseases, Sofia, Bulgaria
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Abstract

The physicochemical behavior of gold nanoparticles (AuNPs) functionalized with two-antennary oligoglycines is studied by analyzing the colloidal stability and size distribution via dynamic light scattering, the surface-charge reconfiguration through zeta-potential, the nanoscale structure using atomic force microscopy, and the thermodynamic interactions with blood serum using differential scanning calorimetry. These analyses provide an initial assessment of the suitability of the two-antennary oligoglycines as a supramolecular surface-engineering ligand for AuNP-based biomedical applications. The two-antennary oligoglycines form stable complexes with AuNPs, creating a coating layer and reversing surface charge. The interaction between bare nanoparticles and blood serum is weak, primarily affecting albumin. On the other hand, the oligoglycines interact strongly with the blood serum proteins altering their stability. Together, these results demonstrate that two-antennary oligoglycines serve as both a stabilizing and functionalizing layer, thereby enhancing nanoparticle stability and modulating biological interactions. This highlights their potential for the design of well-defined nanomaterials and for applications in drug delivery and other biomedical fields.

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Cite

BibTeXRIS
BibTeX
@article{atanasov2026oligoglycinefunctionalized,
  title = {{Oligoglycine-functionalized gold nanoparticles: physicochemical characterisation and serum protein interactions}},
  author = {Ivailo S. Atanasov and Svetla Todinova and Eduarda Encheva and Plamen Tchoukov and Velichka Strijkova and Nadya Stankova and Anna Dikovska and Lidia Gartcheva and Borislava Antonova},
  journal = {BioTechnologia},
  year = {2026},
  month = sep,
  doi = {10.5114/bta/225995},
  url = {https://doi.org/10.5114/bta/225995},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Oligoglycine-functionalized gold nanoparticles: physicochemical characterisation and serum protein interactions
AU  - Ivailo S. Atanasov
AU  - Svetla Todinova
AU  - Eduarda Encheva
AU  - Plamen Tchoukov
AU  - Velichka Strijkova
AU  - Nadya Stankova
AU  - Anna Dikovska
AU  - Lidia Gartcheva
AU  - Borislava Antonova
PY  - 2026
DA  - 2026/09/21
JO  - BioTechnologia
DO  - 10.5114/bta/225995
UR  - https://doi.org/10.5114/bta/225995
AB  - The physicochemical behavior of gold nanoparticles (AuNPs) functionalized with two-antennary oligoglycines is studied by analyzing the colloidal stability and size distribution via dynamic light scattering, the surface-charge reconfiguration through zeta-potential, the nanoscale structure using atomic force microscopy, and the thermodynamic interactions with blood serum using differential scanning calorimetry. These analyses provide an initial assessment of the suitability of the two-antennary oligoglycines as a supramolecular surface-engineering ligand for AuNP-based biomedical applications. The two-antennary oligoglycines form stable complexes with AuNPs, creating a coating layer and reversing surface charge. The interaction between bare nanoparticles and blood serum is weak, primarily affecting albumin. On the other hand, the oligoglycines interact strongly with the blood serum proteins altering their stability. Together, these results demonstrate that two-antennary oligoglycines serve as both a stabilizing and functionalizing layer, thereby enhancing nanoparticle stability and modulating biological interactions. This highlights their potential for the design of well-defined nanomaterials and for applications in drug delivery and other biomedical fields.
SN  - 0860-7796
SN  - 2353-9461
ER  -