Dietary intake and nutritional profiles characterize patients with Inflammatory Bowel Disease from Argentina.
6 affiliations
- 1Instituto de Investigaciones en Ciencias de la Salud (INICSA), CONICET-Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina.
- 2Centro de Investigaciones en Nutrición Humana (CENINH), Escuela de Nutrición, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina.
- 3Fundación Para el Progreso de la Medicina, Córdoba, Argentina.
- 4Hospital Privado Universitario de Córdoba, Córdoba, Argentina.
- 5Instituto Universitario de Ciencias Biomédicas de Córdoba (IUCBC), Centro de Investigación en Medicina Traslacional "Severo R. Amuchástegui" (CIMETSA) U.A. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Córdoba, Argentina.
- 6Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI), Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina.
Abstract
Diet is increasingly recognized as a modifiable determinant of Inflammatory Bowel Disease (IBD) onset and progression, including patients with Ulcerative Colitis (UC) and Crohn's Disease (CD); however, comprehensive nutritional characterization of these populations in Latin America remains scarce. To evaluate dietary intake and nutritional profiles among healthy individuals and IBD patients, focusing on fiber intake and the food-source distribution of dietary tryptophan, and to assess differences according to disease phenotype and activity. An observational cross-sectional study recruited 14 healthy individuals, 15 UC patients, and 10 CD patients at the Hospital Privado Universitario de Córdoba, Argentina. Dietary intake was assessed using a prospective seven-day food record analyzed with Nutrio V2.1 software and energy-adjusted by the Willett residual method. Plasma tryptophan was measured by validated HPLC and disease activity by the Mayo score (UC) or the Harvey-Bradshaw index (CD). No significant differences were observed in total energy, macronutrient, or tryptophan intake between groups. In univariate exploratory analyses, weekly consumption frequency was lower than in healthy individuals for cheese in both UC (p = 0.017) and CD (p = 0.012), and for whole cereals (p = 0.010) and hot beverages (p = 0.003) in UC. The relative contribution of specific food groups to total dietary tryptophan also differed, being lower for cheese in CD (p = 0.037) and for whole cereals in UC (p = 0.008), and higher for meat in UC (p = 0.031). Dietary fiber intake was lower in UC than in healthy individuals (p = 0.033). A negative dietary-plasma tryptophan correlation was identified exclusively in the healthy group (r = -0.4681, p = 0.0469). None of these differences remained significant after FDR correction for multiple testing. Disease-activity subgroup analyses were based on small sample sizes (n as low as 4) and should be interpreted as descriptive observations only. These hypothesis-generating findings suggest that tryptophan food-source distribution and fiber intake, rather than caloric or macronutrient deficits, may represent candidate nutritional distinctions in IBD patients; however, as none withstood correction for multiple testing, confirmation in larger prospective studies is required before any clinical implications can be drawn.
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BibTeX
@article{lambert2026dietary,
title = {{Dietary intake and nutritional profiles characterize patients with Inflammatory Bowel Disease from Argentina.}},
author = {Victoria Lambert and Leonela Tantucci and Dafne Cabrera and Marina L Fernández and Silvia G Correa and María D Román and Domingo C Balderramo and Pablo A Romagnoli},
journal = {Frontiers in nutrition},
year = {2026},
month = oct,
doi = {10.3389/fnut.2026.1913858},
url = {https://europepmc.org/article/MED/42952716},
note = {CC BY},
}
RIS
TY - JOUR
TI - Dietary intake and nutritional profiles characterize patients with Inflammatory Bowel Disease from Argentina.
AU - Victoria Lambert
AU - Leonela Tantucci
AU - Dafne Cabrera
AU - Marina L Fernández
AU - Silvia G Correa
AU - María D Román
AU - Domingo C Balderramo
AU - Pablo A Romagnoli
PY - 2026
DA - 2026/10/14
JO - Frontiers in nutrition
DO - 10.3389/fnut.2026.1913858
UR - https://europepmc.org/article/MED/42952716
AB - Diet is increasingly recognized as a modifiable determinant of Inflammatory Bowel Disease (IBD) onset and progression, including patients with Ulcerative Colitis (UC) and Crohn's Disease (CD); however, comprehensive nutritional characterization of these populations in Latin America remains scarce. To evaluate dietary intake and nutritional profiles among healthy individuals and IBD patients, focusing on fiber intake and the food-source distribution of dietary tryptophan, and to assess differences according to disease phenotype and activity. An observational cross-sectional study recruited 14 healthy individuals, 15 UC patients, and 10 CD patients at the Hospital Privado Universitario de Córdoba, Argentina. Dietary intake was assessed using a prospective seven-day food record analyzed with Nutrio V2.1 software and energy-adjusted by the Willett residual method. Plasma tryptophan was measured by validated HPLC and disease activity by the Mayo score (UC) or the Harvey-Bradshaw index (CD). No significant differences were observed in total energy, macronutrient, or tryptophan intake between groups. In univariate exploratory analyses, weekly consumption frequency was lower than in healthy individuals for cheese in both UC (p = 0.017) and CD (p = 0.012), and for whole cereals (p = 0.010) and hot beverages (p = 0.003) in UC. The relative contribution of specific food groups to total dietary tryptophan also differed, being lower for cheese in CD (p = 0.037) and for whole cereals in UC (p = 0.008), and higher for meat in UC (p = 0.031). Dietary fiber intake was lower in UC than in healthy individuals (p = 0.033). A negative dietary-plasma tryptophan correlation was identified exclusively in the healthy group (r = -0.4681, p = 0.0469). None of these differences remained significant after FDR correction for multiple testing. Disease-activity subgroup analyses were based on small sample sizes (n as low as 4) and should be interpreted as descriptive observations only. These hypothesis-generating findings suggest that tryptophan food-source distribution and fiber intake, rather than caloric or macronutrient deficits, may represent candidate nutritional distinctions in IBD patients; however, as none withstood correction for multiple testing, confirmation in larger prospective studies is required before any clinical implications can be drawn.
SN - 2296-861X
ER -