Mechanisms and Research Progress of LncRNA-Mediated Regulation of Viral Infections.
4 affiliations
- 1College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China.
- 2Nanchang Police Dog Base of Ministry of Public Security, Nanchang 330100, China.
- 3Pet Medical Teaching and Research Office, Department of Animal Science, Jiangxi Biotech Vocational College, Nanchang 330200, China.
- 4Key Laboratory of Animal Pathogen Infection and Immunology of Fujian Province, College of Animal Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Abstract
Long non-coding RNAs (lncRNAs), a class of RNA molecules whose transcripts exceed 200 nucleotides in length and typically lack protein-coding capacity, were once widely regarded as "transcriptional noise." However, recent studies have shown that lncRNAs can encode small peptides and play critical roles in biological processes, including gene expression regulation, cell differentiation, and immune response. Viral infections, as a common disease, can reshape the transcriptome of host cells, in which the differential expression of lncRNAs is a core link in host-virus interactions. This review aims to deeply analyze the multidimensional regulatory mechanisms of lncRNAs in the host antiviral innate immune response. It elaborates in detail on how lncRNAs construct the host antiviral defense by regulating pattern recognition receptor (PRR) signaling pathways, the production and signal transduction of interferons (IFNs), as well as the expression of interferon-stimulated genes (ISGs). Additionally, we conducted an in-depth analysis of the complex functions of lncRNAs in regulating programmed cell death (PCD), including key processes such as pyroptosis, autophagy, and apoptosis, and integrated specific research cases in infections caused by multiple significant viruses, including influenza A virus (IAV), human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We aim to provide novel strategies for the diagnosis, treatment, and prevention of viral diseases.
Related
- Research progress on intestinal probiotics-mediated protection of the intestinal mucosal barrier in ulcerative colitis
- Research progress on molecular mechanisms and signaling pathways of toxic metal exposure-induced lung fibrosis
- Research progress on the mechanisms by which gut microbiota dysbiosis remodels the bone marrow neuroimmune microenvironment to drive age-related osteoporosis
- Research progress on the epidemiology and diagnostic technologies of urinary tract infections in kidney transplant recipients
- Mechanisms of antibody-dependent enhancement and its research progress in animal coronaviruses
BibTeX
@article{peng2026mechanisms,
title = {{Mechanisms and Research Progress of LncRNA-Mediated Regulation of Viral Infections.}},
author = {Menghua Peng and Fenfang Luo and Ning Li},
journal = {Viruses},
year = {2026},
month = oct,
doi = {10.3390/v18101141},
url = {https://europepmc.org/article/MED/42944060},
note = {CC BY},
}
RIS
TY - JOUR
TI - Mechanisms and Research Progress of LncRNA-Mediated Regulation of Viral Infections.
AU - Menghua Peng
AU - Fenfang Luo
AU - Ning Li
PY - 2026
DA - 2026/10/14
JO - Viruses
DO - 10.3390/v18101141
UR - https://europepmc.org/article/MED/42944060
AB - Long non-coding RNAs (lncRNAs), a class of RNA molecules whose transcripts exceed 200 nucleotides in length and typically lack protein-coding capacity, were once widely regarded as "transcriptional noise." However, recent studies have shown that lncRNAs can encode small peptides and play critical roles in biological processes, including gene expression regulation, cell differentiation, and immune response. Viral infections, as a common disease, can reshape the transcriptome of host cells, in which the differential expression of lncRNAs is a core link in host-virus interactions. This review aims to deeply analyze the multidimensional regulatory mechanisms of lncRNAs in the host antiviral innate immune response. It elaborates in detail on how lncRNAs construct the host antiviral defense by regulating pattern recognition receptor (PRR) signaling pathways, the production and signal transduction of interferons (IFNs), as well as the expression of interferon-stimulated genes (ISGs). Additionally, we conducted an in-depth analysis of the complex functions of lncRNAs in regulating programmed cell death (PCD), including key processes such as pyroptosis, autophagy, and apoptosis, and integrated specific research cases in infections caused by multiple significant viruses, including influenza A virus (IAV), human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We aim to provide novel strategies for the diagnosis, treatment, and prevention of viral diseases.
SN - 1999-4915
ER -