Beyond Hematuria: An Unexpected Diagnosis of Autosomal Dominant Polycystic Kidney Disease in a Young Adult Without a Family History.
- 1Medicine, Ross University School of Medicine, Miramar, USA.
- 2Internal Medicine, Dignity Health - California Hospital Medical Center, Los Angeles, USA.
Abstract
Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common inherited renal disorders, yet its diagnosis may be delayed when initial symptoms overlap with more prevalent conditions such as urinary tract infection or nephrolithiasis. Premature diagnostic closure on these common etiologies can delay recognition of underlying renal disease, particularly in young adults without a known family history. We present the case of a 28-year-old man with no personal or family history of renal disease who was evaluated for gross hematuria. Renal imaging revealed extensive bilateral renal cysts. These findings, along with previously unrecognized hypertension and mild renal impairment, are consistent with ADPKD. This case emphasizes the importance of considering structural renal disease beyond common urinary etiologies in young adults presenting with unexplained hematuria and new-onset hypertension, even in the absence of a family history. Early recognition may prevent diagnostic delay, facilitate timely nephrology referral, and enable initiation of renoprotective therapy.
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BibTeX
@article{moslehshirazi2026beyond,
title = {{Beyond Hematuria: An Unexpected Diagnosis of Autosomal Dominant Polycystic Kidney Disease in a Young Adult Without a Family History.}},
author = {Souzan Moslehshirazi and Mauricio Chiriboga and Asya Starks and Salvatore Grasso and Peyman Arghavani},
journal = {Cureus},
year = {2026},
month = sep,
doi = {10.7759/cureus.117085},
url = {https://europepmc.org/article/MED/42953835},
note = {CC BY},
}
RIS
TY - JOUR
TI - Beyond Hematuria: An Unexpected Diagnosis of Autosomal Dominant Polycystic Kidney Disease in a Young Adult Without a Family History.
AU - Souzan Moslehshirazi
AU - Mauricio Chiriboga
AU - Asya Starks
AU - Salvatore Grasso
AU - Peyman Arghavani
PY - 2026
DA - 2026/09/28
JO - Cureus
DO - 10.7759/cureus.117085
UR - https://europepmc.org/article/MED/42953835
AB - Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common inherited renal disorders, yet its diagnosis may be delayed when initial symptoms overlap with more prevalent conditions such as urinary tract infection or nephrolithiasis. Premature diagnostic closure on these common etiologies can delay recognition of underlying renal disease, particularly in young adults without a known family history. We present the case of a 28-year-old man with no personal or family history of renal disease who was evaluated for gross hematuria. Renal imaging revealed extensive bilateral renal cysts. These findings, along with previously unrecognized hypertension and mild renal impairment, are consistent with ADPKD. This case emphasizes the importance of considering structural renal disease beyond common urinary etiologies in young adults presenting with unexplained hematuria and new-onset hypertension, even in the absence of a family history. Early recognition may prevent diagnostic delay, facilitate timely nephrology referral, and enable initiation of renoprotective therapy.
SN - 2168-8184
ER -