ZFP36-ferroptosis axis as a key renal protective pathway in diabetic kidney disease
Abstract
Diabetic Kidney Disease (DKD) is strongly related to ferroptosis, an iron-dependent form of programmed cell death characterized by the accumulation of lipid peroxides. While ferroptosis is a pivotal mediator in DKD pathogenesis, its upstream regulatory mechanism remains poorly defined, thus impeding the development of targeted therapeutic strategies. In this study, by integrating multi-omics clinical data (GSE96804 and GSE104954) and combining machine learning algorithms, the RNA-binding protein ZFP36 was screened out as the core regulatory factor of ferroptosis in DKD. The results revealed that the expression level of ZFP36 in the DKD group was significantly lower than that in the normal group. Functional experiments demonstrated that overexpression of ZFP36 could significantly alleviate lipid peroxidation, iron ion accumulation, and cellular fibrosis, thereby inhibiting ferroptosis and alleviating kidney damage. Transcriptome analysis further revealed that ZFP36 regulated key genes related to oxidative stress and iron metabolism. Additionally, molecular docking simulations revealed strong binding affinity between ZFP36 and bioactive natural products such as berberine and astragalus, providing a potential mechanism for its renal protective effect. Overall, ZFP36 was hereby established as an important inhibitor of ferroptosis in DKD, highlighting its potential as both a biomarker and a therapeutic target for its precision diagnosis and intervention.
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BibTeX
@article{li2026zfp36ferroptosis,
title = {{ZFP36-ferroptosis axis as a key renal protective pathway in diabetic kidney disease}},
author = {Anni Li and Yuxuan Ye and Huimin Cao and Jiawei Hu and Min Shi and Juan Zhang and Yiyuan Zhang and Yuting Liu and Bixia Gu and Hong Zhang},
journal = {Endocrine Journal},
year = {2026},
month = aug,
doi = {10.1507/endocrj.ej25-0648},
url = {https://www.jstage.jst.go.jp/article/endocrj/73/8/73_EJ25-0648/_article},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - ZFP36-ferroptosis axis as a key renal protective pathway in diabetic kidney disease
AU - Anni Li
AU - Yuxuan Ye
AU - Huimin Cao
AU - Jiawei Hu
AU - Min Shi
AU - Juan Zhang
AU - Yiyuan Zhang
AU - Yuting Liu
AU - Bixia Gu
AU - Hong Zhang
PY - 2026
DA - 2026/08/03
JO - Endocrine Journal
DO - 10.1507/endocrj.ej25-0648
UR - https://www.jstage.jst.go.jp/article/endocrj/73/8/73_EJ25-0648/_article
AB - Diabetic Kidney Disease (DKD) is strongly related to ferroptosis, an iron-dependent form of programmed cell death characterized by the accumulation of lipid peroxides. While ferroptosis is a pivotal mediator in DKD pathogenesis, its upstream regulatory mechanism remains poorly defined, thus impeding the development of targeted therapeutic strategies. In this study, by integrating multi-omics clinical data (GSE96804 and GSE104954) and combining machine learning algorithms, the RNA-binding protein ZFP36 was screened out as the core regulatory factor of ferroptosis in DKD. The results revealed that the expression level of ZFP36 in the DKD group was significantly lower than that in the normal group. Functional experiments demonstrated that overexpression of ZFP36 could significantly alleviate lipid peroxidation, iron ion accumulation, and cellular fibrosis, thereby inhibiting ferroptosis and alleviating kidney damage. Transcriptome analysis further revealed that ZFP36 regulated key genes related to oxidative stress and iron metabolism. Additionally, molecular docking simulations revealed strong binding affinity between ZFP36 and bioactive natural products such as berberine and astragalus, providing a potential mechanism for its renal protective effect. Overall, ZFP36 was hereby established as an important inhibitor of ferroptosis in DKD, highlighting its potential as both a biomarker and a therapeutic target for its precision diagnosis and intervention.
SN - 1348-4540
SN - 0918-8959
ER -