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Peer-reviewedCC BY-NC-ND 4.0Chemistry & Biodiversity

Auricularia auricula‐judae Peptides Modulate Lipid Metabolic Disturbances and Gut Microbiota Composition in High‐Fat‐Diet‐Fed Mice

  • Feiyu Yang1,2
  • Jia Tao2
  • Xin Li1
  • Jing Sun1
  • Xinyi Pang1
  • Peihua Ma3
  • Xiangfei Li1
  • Yingjian Lu1
  1. 1College of Food Science and Engineering Nanjing University of Finance and Economics/Collaborative Innovation Center for Modern Grain Circulation and Safety Nanjing China
  2. 2College of Food Science and Technology Nanjing Agricultural University Nanjing China
  3. 3Institute of Food Science and Technology Chinese Academy of Agricultural Sciences Beijing China
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Abstract

High‐calorie diets and sedentary lifestyles have led to a rising global prevalence of obesity, which constitutes a serious publichealth challenge. In this study, we investigated the antiobesity effects and underlying molecular mechanisms of Auricularia auricula‐judae peptides (AAP) in high‐fat‐diet‐induced obese mice. AAP intervention markedly restrained bodyweight gain. At the highest dose, the final body weight of AAP‐treated mice was approximately 20% lower than that of the untreated high‐fat‐diet group. AAP reduced plasma and hepatic triglyceride (TG) and total cholesterol (TC) levels with a dose‐dependent tendency and restored the histological morphology of liver and epididymal white adipose tissue. AAP mediated reshaped gut microbiota composition, improved intestinal homeostasis, and mitigated hepatic chronic inflammation. Moreover AAP significantly elevated fecal total bile acid (TBA) content and up‐regulated the hepatic mRNA expression of lipolysis‐related genes Cpt1, Ppar‐α, Atgl and cholesterol catabolic gene Cyp7a1 thereby restoring hepatic lipid metabolic homeostasis. Collectively these findings demonstrate that AAP exerts promising antiobesity activity in obese mice and has great potential for development as functional food ingredients.

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Cite

BibTeXRIS
BibTeX
@article{yang2026auricularia,
  title = {{Auricularia auricula‐judae Peptides Modulate Lipid Metabolic Disturbances and Gut Microbiota Composition in High‐Fat‐Diet‐Fed Mice}},
  author = {Feiyu Yang and Jia Tao and Xin Li and Jing Sun and Xinyi Pang and Peihua Ma and Xiangfei Li and Yingjian Lu},
  journal = {Chemistry \& Biodiversity},
  year = {2026},
  month = oct,
  doi = {10.1002/cbdv.71845},
  url = {https://doi.org/10.1002/cbdv.71845},
  note = {CC BY-NC-ND 4.0},
}
RIS
TY  - JOUR
TI  - Auricularia auricula‐judae Peptides Modulate Lipid Metabolic Disturbances and Gut Microbiota Composition in High‐Fat‐Diet‐Fed Mice
AU  - Feiyu Yang
AU  - Jia Tao
AU  - Xin Li
AU  - Jing Sun
AU  - Xinyi Pang
AU  - Peihua Ma
AU  - Xiangfei Li
AU  - Yingjian Lu
PY  - 2026
DA  - 2026/10/01
JO  - Chemistry & Biodiversity
DO  - 10.1002/cbdv.71845
UR  - https://doi.org/10.1002/cbdv.71845
AB  - High‐calorie diets and sedentary lifestyles have led to a rising global prevalence of obesity, which constitutes a serious publichealth challenge. In this study, we investigated the antiobesity effects and underlying molecular mechanisms of Auricularia auricula‐judae peptides (AAP) in high‐fat‐diet‐induced obese mice. AAP intervention markedly restrained bodyweight gain. At the highest dose, the final body weight of AAP‐treated mice was approximately 20% lower than that of the untreated high‐fat‐diet group. AAP reduced plasma and hepatic triglyceride (TG) and total cholesterol (TC) levels with a dose‐dependent tendency and restored the histological morphology of liver and epididymal white adipose tissue. AAP mediated reshaped gut microbiota composition, improved intestinal homeostasis, and mitigated hepatic chronic inflammation. Moreover AAP significantly elevated fecal total bile acid (TBA) content and up‐regulated the hepatic mRNA expression of lipolysis‐related genes Cpt1, Ppar‐α, Atgl and cholesterol catabolic gene Cyp7a1 thereby restoring hepatic lipid metabolic homeostasis. Collectively these findings demonstrate that AAP exerts promising antiobesity activity in obese mice and has great potential for development as functional food ingredients.
SN  - 1612-1872
SN  - 1612-1880
ER  -